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公开(公告)号：US20210276984A1
公开(公告)日：2021-09-09
申请号：US17164045
申请日：2021-02-01
Inventor： Gianni CHESSARI , Steven HOWARD , Ildiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , C07D413/06 , C07D403/12 , C07F9/572 , A61P35/00
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.
Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.-
公开(公告)号：US20250092027A1
公开(公告)日：2025-03-20
申请号：US18767400
申请日：2024-07-09
Inventor： Gianni CHESSARI , Steven HOWARD , Ildiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , A61K31/4035 , A61P35/00 , C07D209/48 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07F9/572
Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.
Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.-
公开(公告)号：US20180118684A1
公开(公告)日：2018-05-03
申请号：US15715900
申请日：2017-09-26
Applicant: CANCER RESEARCH TECHNOLOGY LIMITED
Inventor： Bernard Thomas GOLDING , Christiane RIEDINGER , Roger John GRIFFIN , Ian Robert HARDCASTLE , Eric VALEUR , Anna Frances WATSON , Martin NOBLE
IPC: C07D209/49 , A61K45/06 , A61K31/4402 , C07D209/48 , C07D403/06 , C07D401/06 , A61K31/4035
CPC classification number: C07D209/49 , A61K31/4035 , A61K31/4402 , A61K45/06 , C07D209/48 , C07D401/06 , C07D403/06
Abstract: A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.
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公开(公告)号：US20200079761A1
公开(公告)日：2020-03-12
申请号：US16535931
申请日：2019-08-08
Inventor： Gianni CHESSARI , Steven HOWARD , lldiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mantyla NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , A61P35/00 , C07D413/06 , C07D403/12 , C07F9/572
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US20160355478A1
公开(公告)日：2016-12-08
申请号：US15150947
申请日：2016-05-10
Applicant: CANCER RESEARCH TECHNOLOGY LIMITED
Inventor： Bernard Thomas GOLDING , Christiane RIEDINGER , Roger John GRIFFIN , Ian Robert HARDCASTLE , Eric VALEUR , Anna Frances WATSON , Martin NOBLE
IPC: C07D209/49 , A61K45/06 , C07D401/06 , A61K31/4402 , C07D209/48 , A61K31/4035
CPC classification number: C07D209/49 , A61K31/4035 , A61K31/4402 , A61K45/06 , C07D209/48 , C07D401/06 , C07D403/06
Abstract: A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.
Abstract translation: 式（I）化合物或式（II）化合物或其药学上可接受的盐，其中R 1 -R 7和X如说明书中所定义，以及这些化合物在治疗中的用途，特别是在治疗癌症或作为 MDM2蛋白与p53相互作用的抑制剂。
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Patent Agency Ranking
公开(公告)号：US20140194486A1
公开(公告)日：2014-07-10
申请号：US14085632
申请日：2013-11-20
Applicant: CANCER RESEARCH TECHNOLOGY LIMITED
Inventor： Bernard Thomas GOLDING , Christiane Riedinger , Roger John Griffin , Ian Robert Hardcastle , Eric Valeur , Anna Frances Watson , Martin Noble
IPC: A61K31/4035 , C07D209/48
CPC classification number: C07D209/49 , A61K31/4035 , A61K31/4402 , A61K45/06 , C07D209/48 , C07D401/06 , C07D403/06
Abstract: A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in therapy, in particular in treating cancer or as an inhibitor of the interaction of the MDM2 protein with p53.
Abstract translation: 式（I）化合物或式（II）化合物或其药学上可接受的盐，其中R 1 -R 7和X如说明书中所定义，以及这些化合物在治疗中的用途，特别是在治疗癌症或作为 MDM2蛋白与p53相互作用的抑制剂。
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公开(公告)号：US20220106287A1
公开(公告)日：2022-04-07
申请号：US17228151
申请日：2021-04-12
Inventor： Gianni CHESSARI , Steven HOWARD , Ildiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D401/06 , A61K31/4439 , C07D405/14 , C07D487/04 , A61K31/5377 , C07D403/06 , C07D409/14 , C07D487/08 , A61K31/496 , A61K31/501 , C07D413/14 , A61K45/06 , C07D403/14 , C07D407/14 , C07D417/14 , A61K31/444 , C07D401/14 , A61K31/506 , A61P35/00 , C07B59/00 , A61K31/4545
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.
Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.-
公开(公告)号：US20200247789A2
公开(公告)日：2020-08-06
申请号：US16535931
申请日：2019-08-08
Inventor： Gianni CHESSARI , Steven HOWARD , Ildiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , C07D403/06 , C07D405/12 , C07D413/12 , C07D209/48 , A61P35/00 , C07D413/06 , C07D403/12 , C07F9/572
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US20190055215A1
公开(公告)日：2019-02-21
申请号：US15763724
申请日：2016-09-29
Inventor： Gianni CHESSARI , Steven HOWARD , Ildiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST.DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D401/06 , A61K31/4439 , A61K45/06 , C07D403/06 , A61K31/501 , A61K31/506 , C07D401/14 , C07D409/14 , A61K31/496 , C07D407/14 , A61K31/444 , A61K31/4545 , A61K31/5377 , C07D417/14 , A61P35/00
CPC classification number: C07D401/06 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , A61P35/00 , C07B59/002 , C07B2200/05 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/08
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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公开(公告)号：US20190016708A1
公开(公告)日：2019-01-17
申请号：US15763698
申请日：2016-09-29
Inventor： Gianni CHESSARI , Steven HOWARD , IIdiko Maria BUCK , Benjamin David CONS , Christopher Norbert JOHNSON , Rhian Sara HOLVEY , David Charles REES , Jeffrey David ST. DENIS , Emiliano TAMANINI , Bernard Thomas GOLDING , Ian Robert HARDCASTLE , Celine Florence CANO , Duncan Charles MILLER , Sarah CULLY , Martin Edward Mäntylä NOBLE , Roger John GRIFFIN , James Daniel OSBORNE , Joanne PEACH , Arwel LEWIS , Kim Louise HIRST , Benjamin Paul WHITTAKER , David Wyn WATSON , Dale Robert MITCHELL
IPC: C07D405/14 , C07D413/12 , C07D405/12 , C07D403/06 , A61P35/00 , C07D209/48
CPC classification number: C07D405/14 , A61P35/00 , C07B2200/05 , C07D209/48 , C07D403/06 , C07D403/12 , C07D405/12 , C07D413/06 , C07D413/12 , C07F9/5728
Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims.Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.
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