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公开(公告)号：US09849131B2
公开(公告)日：2017-12-26
申请号：US15348091
申请日：2016-11-10
发明人： Giuseppe Alvaro , Anne Decor , Stefano Fontana , Dieter Hamprecht , Charles Large , Agostino Marasco
IPC分类号： A61K31/506 , C07D233/76 , C07D401/04 , C07D403/04 , C07D239/22 , C07D239/47 , C07D233/72 , A61K31/4166 , A61K31/4439 , C07D213/643
CPC分类号： A61K31/506 , A61K31/4166 , A61K31/4439 , C07D213/643 , C07D233/72 , C07D233/76 , C07D239/22 , C07D239/47 , C07D401/04 , C07D403/04
摘要： The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
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公开(公告)号：US10058551B2
公开(公告)日：2018-08-28
申请号：US15722623
申请日：2017-10-02
发明人： Giuseppe Alvaro , Anne Decor , Stefano Fontana , Dieter Hamprecht , Charles Large , Agostino Marasco
IPC分类号： A61K31/506 , C07D239/22 , C07D401/04 , C07D403/04 , C07D233/72 , A61K31/4166 , A61K31/4439 , C07D239/47 , C07D233/76 , C07D213/643
CPC分类号： A61K31/506 , A61K31/4166 , A61K31/4439 , C07D213/643 , C07D233/72 , C07D233/76 , C07D239/22 , C07D239/47 , C07D401/04 , C07D403/04
摘要： The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.
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公开(公告)号：US09216967B2
公开(公告)日：2015-12-22
申请号：US14226988
申请日：2014-03-27
发明人： Giuseppe Alvaro , Anne Decor , Stefano Fontana , Dieter Hamprecht , Charles Large , Agostino Marasco
IPC分类号： C07D403/04 , C07D233/76 , C07D401/04 , C07D239/22 , C07D239/47 , C07D233/72 , C07D213/643
CPC分类号： A61K31/506 , A61K31/4166 , A61K31/4439 , C07D213/643 , C07D233/72 , C07D233/76 , C07D239/22 , C07D239/47 , C07D401/04 , C07D403/04
摘要： The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.
摘要翻译： 本发明提供式（Ia）化合物及其药学上可接受的盐。 本发明还提供了化合物或盐作为Kv3.1和/或Kv3.2的调节剂的用途，以及用于治疗需要Kv3.1和/或Kv3.2调节剂的疾病或病症，例如抑郁症 情绪障碍，听觉障碍，精神分裂症，物质滥用障碍，睡眠障碍或癫痫。
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公开(公告)号：US11197859B2
公开(公告)日：2021-12-14
申请号：US16985160
申请日：2020-08-04
发明人： Giuseppe Alvaro , Paolo Dambruoso , Simona Tommasi , Anne Decor , Charles Large , Agostino Marasco
IPC分类号： C07D413/12 , A61K31/506 , C07D405/12 , C07D413/14 , C07D307/79 , C07D307/94 , C07D405/14 , C07D317/46 , A61K31/4439
摘要： The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
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公开(公告)号：US11583527B2
公开(公告)日：2023-02-21
申请号：US17517620
申请日：2021-11-02
发明人： Giuseppe Alvaro , Paolo Dambruoso , Simona Tommasi , Anne Decor , Charles Large , Agostino Marasco
IPC分类号： C07D413/12 , A61K31/506 , C07D405/12 , C07D413/14 , C07D307/79 , C07D307/94 , C07D405/14 , C07D317/46 , A61K31/4439
摘要： The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
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公开(公告)号：US20220054490A1
公开(公告)日：2022-02-24
申请号：US17517620
申请日：2021-11-02
发明人： Giuseppe Alvaro , Paolo Dambruoso , Simona Tommasi , Anne Decor , Charles Large , Agostino Marasco
IPC分类号： A61K31/506 , C07D413/12 , C07D405/12 , C07D413/14 , C07D307/79 , C07D307/94 , C07D405/14 , C07D317/46 , A61K31/4439
摘要： The disclosure provides compounds of formula (I): said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
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公开(公告)号：US20150018377A1
公开(公告)日：2015-01-15
申请号：US14226988
申请日：2014-03-27
发明人： Giuseppe ALVARO , Anne Decor , Stefano Fontana , Dieter Hamprecht , Charles Large , Agostino Marasco
IPC分类号： C07D403/04 , C07D401/04 , C07D233/72
CPC分类号： A61K31/506 , A61K31/4166 , A61K31/4439 , C07D213/643 , C07D233/72 , C07D233/76 , C07D239/22 , C07D239/47 , C07D401/04 , C07D403/04
摘要： The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizophrenia, substance abuse disorders, sleep disorders or epilepsy.
摘要翻译： 本发明提供式（Ia）化合物及其药学上可接受的盐。 本发明还提供了化合物或盐作为Kv3.1和/或Kv3.2的调节剂的用途，以及用于治疗需要Kv3.1和/或Kv3.2调节剂的疾病或病症，例如抑郁症 情绪障碍，听觉障碍，精神分裂症，物质滥用障碍，睡眠障碍或癫痫。
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公开(公告)号：US10265316B2
公开(公告)日：2019-04-23
申请号：US15621400
申请日：2017-06-13
发明人： Giuseppe Alvaro , Paolo Dambruoso , Simona Tommasi , Anne Decor , Charles Large , Agostino Marasco
IPC分类号： C07D405/12 , A61K31/506 , C07D413/12 , C07D413/14 , C07D307/79 , C07D307/94 , C07D405/14 , C07D317/46 , A61K31/4439
摘要： The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
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公开(公告)号：US20140107139A1
公开(公告)日：2014-04-17
申请号：US14124516
申请日：2012-06-07
IPC分类号： C07D405/14 , C07D311/76 , C07D307/93 , C07D307/87 , C07D405/12
CPC分类号： C07D307/93 , C07D307/87 , C07D307/94 , C07D311/76 , C07D401/04 , C07D403/04 , C07D405/12 , C07D405/14
摘要： The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.
摘要翻译： 本发明提供式（I）化合物：所述化合物是Kv3通道的抑制剂，并且用于预防或治疗相关病症。
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