公开(公告)号：US20170306008A1

公开(公告)日：2017-10-26

申请号：US15513021

申请日：2015-09-25

申请人： AVEO Pharmaceuticals, Inc.

发明人： Jeno Gyuris ,  Lorena Lerner ,  Jie Lin

IPC分类号： C07K16/22 ,  A61K31/555 ,  A61K33/24 ,  A61K39/395 ,  A61K39/00

CPC分类号： C07K16/22 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7068 ,  A61K33/24 ,  A61K39/3955 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/76 ,  A61K2300/00

摘要： Methods are provided for improved treatment of subjects with cancer anorexia-cachexia syndrome, comprising treatment with a combination of at least one anti-cancer agent and at least one GDF 15 modulator. Methods are further provided for improved treatment of subjects with anti-cancer agents which induce cachexia, comprising further treating the subject with at least one GDF 15 modulator.

公开(公告)号：US20190292253A1

公开(公告)日：2019-09-26

申请号：US16179352

申请日：2018-11-02

申请人： AVEO Pharmaceuticals, Inc.

发明人： Jeno Gyuris ,  Lorena Lerner ,  Jie Lin

IPC分类号： C07K16/22 ,  A61K31/704 ,  A61K33/24 ,  A61K31/555 ,  A61K45/06 ,  A61K39/395 ,  A61K31/7068

摘要： Methods are provided for improved treatment of subjects with cancer anorexia-cachexia syndrome, comprising treatment with a combination of at least one anti-cancer agent and at least one GDF15 modulator. Methods are further provided for improved treatment of subjects with anti-cancer agents which induce cachexia, comprising further treating the subject with at least one GDF15 modulator.

公开(公告)号：US20230295285A1

公开(公告)日：2023-09-21

申请号：US17939634

申请日：2022-09-07

申请人： AVEO Pharmaceuticals, Inc.

发明人： Jeno Gyuris ,  Lorena Lerner ,  Jie Lin

IPC分类号： C07K16/22 ,  A61K31/555 ,  A61K39/395 ,  A61K31/704 ,  A61K31/7068 ,  A61K45/06 ,  A61K33/243

CPC分类号： C07K16/22 ,  A61K31/555 ,  A61K39/39558 ,  A61K31/704 ,  A61K31/7068 ,  A61K45/06 ,  A61K33/243 ,  A61K39/3955 ,  C07K2317/76 ,  A61K2039/505

摘要： Methods are provided for improved treatment of subjects with cancer anorexia-cachexia syndrome, comprising treatment with a combination of at least one anti-cancer agent and at least one GDF15 modulator. Methods are further provided for improved treatment of subjects with anti-cancer agents which induce cachexia, comprising further treating the subject with at least one GDF15 modulator.

公开(公告)号：US09096664B2

公开(公告)日：2015-08-04

申请号：US14044278

申请日：2013-10-02

申请人： AVEO Pharmaceuticals, Inc.

发明人： William M. Winston, Jr. ,  S. Kirk Wright ,  May Han ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris ,  Arnold Horwitz

IPC分类号： C07H21/04 ,  C12N15/63 ,  C12N5/12 ,  C12N15/00 ,  C07K16/22 ,  A61K39/00

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。

公开(公告)号：US20140178935A1

公开(公告)日：2014-06-26

申请号：US14044278

申请日：2013-10-02

申请人： AVEO Pharmaceuticals, Inc.

发明人： William M. Winston, JR. ,  S. Kirk Wright ,  May Han ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris ,  Arnold Horwitz

IPC分类号： C07K16/22

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

摘要翻译： 本发明提供结合并中和肝细胞生长因子（HGF），特别是人HGF的活性的结合蛋白家族。 结合蛋白可用作诊断和/或治疗剂。 关于它们的治疗活性，结合蛋白可用于治疗某些HGF应答性病症，例如某些HGF反应性肿瘤。

公开(公告)号：US20140178934A1

公开(公告)日：2014-06-26

申请号：US14039912

申请日：2013-09-27

申请人： AVEO Pharmaceuticals, Inc.

发明人： May Han ,  S. Kirk Wright ,  William M. Winston, JR. ,  Lyne Breault ,  Jie Lin ,  Bijan Etemad-Gilbertson ,  Christine Knuehl ,  Jeno Gyuris

IPC分类号： C07K16/22

CPC分类号： C07K16/22 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

公开(公告)号：US20140045715A1

公开(公告)日：2014-02-13

申请号：US13958836

申请日：2013-08-05

申请人： AVEO Pharmaceuticals, Inc.

发明人： Jie Lin ,  Bin Feng ,  Murray Robinson ,  Feng Jiang ,  Xiaojian Sun

IPC分类号： G01N33/574 ,  C12Q1/68

CPC分类号： G01N33/57492 ,  C12Q1/6886 ,  G01N33/57407 ,  G01N2333/70596 ,  G01N2800/52

摘要： A diagnostic method for predicting whether a human tumor will be sensitive or resistant to treatment with tivozanib (AV-951) is disclosed. The method is based on measurement of macrophage content in a tissue sample from a tumor. Measurement of macrophage content can be based on analysis of macrophage marker gene expression, e.g., by RNA analysis or immunohistochemistry.

摘要翻译： 公开了一种诊断方法，用于预测人肿瘤是否敏感或对利托那尼治疗有抗药性（AV-951）。 该方法基于来自肿瘤的组织样品中巨噬细胞含量的测量。 巨噬细胞含量的测定可以基于巨噬细胞标记基因表达的分析，例如通过RNA分析或免疫组织化学。