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公开(公告)号：US11793778B2
公开(公告)日：2023-10-24
申请号：US17157000
申请日：2021-01-25
发明人： Gary Millet
IPC分类号： A61K31/19 , A61K31/121
CPC分类号： A61K31/19 , A61K31/121 , A23V2200/3322
摘要： Compositions for delivering ketone bodies to a subject include one or more beta-hydroxybutyrate salts, one or more acetoacetate salts, beta-hydroxybutyric acid, and optionally acetoacetic acid. The compositions may optionally include one or more ketone body esters, such as one or more beta-hydroxybutyrate esters and/or one or more acetoacetate esters. An example composition contains about 2% to about 98% on a molar basis of the one or more beta-hydroxybutyrate salts and the one or more acetoacetate salts, about 2% to about 98% on a molar basis of the beta-hydroxybutyrate free acid and optionally the acetoacetate free acid, and optionally about 2% to about 98% on a molar basis of one or more ketone body esters.
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公开(公告)号：US20220133673A1
公开(公告)日：2022-05-05
申请号：US17555724
申请日：2021-12-20
发明人： Gary Millet
IPC分类号： A61K31/22 , A61K31/19 , A61K9/00 , A61K31/047
摘要： Compositions and methods for producing elevated blood levels of ketone bodies and modifying metabolic function in a mammal. Compositions include at least one ester of S-beta-hydroxybutyrate and/or a mono- or di-ester of S-1,3-butanediol and at least one ketone body component. The ketone body component includes beta-hydroxybutyrate, acetoacetate, or both. The beta-hydroxybutyrate is R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, or both. When the ketone body component is S-beta-hydroxybutyrate, the 1,3-butanediol is R-1,3-butanediol, S-1,3-butanediol, or both. Compositions may comprise a keto stack of multiple forms of ketone bodies.
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公开(公告)号：US11129802B2
公开(公告)日：2021-09-28
申请号：US16551570
申请日：2019-08-26
发明人： Gary Millet
摘要： Disclosed herein are “ketonnabidiol” or “ketannabidiol” compositions including a combination of: (1) cannabidiol (CBD) and/or cannabidiolic acid (CBDA); (2) a ketone body component such as beta-hydroxybutyrate (BHB) and/or acetoacetate; and (3) a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such ketonnabidiol compositions for producing desired physiological effects, such as fat loss, in a mammal. The ketonnabidiol compositions beneficially enhance fat loss through ketosis while also reducing the duration and/or severity of unpleasant “keto flu” symptoms typically associated with ketosis.
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公开(公告)号：US11033553B2
公开(公告)日：2021-06-15
申请号：US16849901
申请日：2020-04-15
发明人： Gary Millet
IPC分类号： A61K36/258 , A61K31/52 , A61K31/335 , A61K47/46 , A61K31/522 , A23L33/10 , A61K31/198 , A61K31/353 , A23L2/38 , A61K45/06
摘要： An energy-promoting composition includes a stimulant component such as caffeine, a vasodilator component, an energy source including an exogenous ketone body component, and optionally a nootropic component. The separate components beneficially and synergistically interact with one another enhances the overall energy-promoting effect of the composition more rapidly and to a greater degree than if one or more of the components are omitted. The energy-promoting composition is also formulated to minimize the crash effect common to stimulants such as energy drinks.
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公开(公告)号：US10980772B2
公开(公告)日：2021-04-20
申请号：US16272328
申请日：2019-02-11
发明人： Gary Millet
IPC分类号： A61K31/352 , A61K47/10 , A61K47/14 , A61P25/04 , A61P29/00 , A61P35/00 , A61P25/24 , A61K31/19
摘要： Disclosed herein are “ketannabis” (or “ketonnabis”) compositions including a combination of: (1) tetrahydrocannabinol (THC); (2) a ketone body component such as beta-hydroxybutyrate (BHB) and/or acetoacetate; and (3) a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such ketannabis compositions for producing desired physiological effects. The ketannabis compositions beneficially enhance the euphoric effects of THC without aggravating common side effects or even acting to reduce common side effects such as anxiety, disruption of short-term memory, appetite increases, heart rate increases, and blood pressure changes.
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公开(公告)号：US20200061021A1
公开(公告)日：2020-02-27
申请号：US16272328
申请日：2019-02-11
发明人： Gary Millet
摘要： Disclosed herein are “ketannabis” (or “ketonnabis”) compositions including a combination of: (1) tetrahydrocannabinol (THC); (2) a ketone body component such as beta-hydroxybutyrate (BHB) and/or acetoacetate; and (3) a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such ketannabis compositions for producing desired physiological effects. The ketannabis compositions beneficially enhance the euphoric effects of THC without aggravating common side effects or even acting to reduce common side effects such as anxiety, disruption of short-term memory, appetite increases, heart rate increases, and blood pressure changes.
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7.发明申请公开(公告)号：US20190151267A1
公开(公告)日：2019-05-23
申请号：US16224408
申请日：2018-12-18
发明人： Gary Millet
IPC分类号： A61K31/19 , A61K31/047 , A61K9/00
CPC分类号： A61K31/19 , A61K9/0053 , A61K31/047
摘要： Ketogenic compositions including a non-racemic mixture of beta-hydroxybutyrate (BHB) enriched with the R-enantiomer are formulated to increase ketone body level in a subject. The non-racemic mixture of BHB is enriched with the R-enantiomer to elevate ketone bodies and increase the rate at which ketosis is achieved yet contains an amount of the S-enantiomer sufficient to provide alternative benefits as discussed herein. In some aspects a composition for increasing ketone body level in a subject contains a dietetically or pharmaceutically acceptable carrier and a non-racemic mixture of R-beta-hydroxybutyrate and S-beta-hydroxybutyrate, wherein the non-racemic mixture of R-beta-hydroxybutyrate and S-beta-hydroxybutyrate contains from about 55% to 98% by enantiomeric equivalents of the R-beta-hydroxybutyrate and from about 45% to about 2% by enantiomeric equivalents of S-beta-hydroxybutyrate enantiomer.
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公开(公告)号：US11950616B2
公开(公告)日：2024-04-09
申请号：US17320657
申请日：2021-05-14
发明人： Gary Millet
IPC分类号： A61K36/258 , A23L2/52 , A23L33/105 , A61K31/12 , A61K31/335 , A61K31/52 , A61K31/522
CPC分类号： A23L33/105 , A23L2/52 , A61K31/522
摘要： An energy-promoting composition includes an exogenous ketone body component that provides a source of caloric energy, a vasodilator component, a stimulant component, such as caffeine, and optionally a nootropic component. In most if not all cases, the vasodilator, stimulant, and nootropic components do not themselves provide a source of caloric energy but may increase metabolism of available caloric energy. The separate components beneficially and synergistically interact with one another to enhance the overall energy-promoting effect of the composition more rapidly and to a greater degree than if one or more of the components are omitted. The energy-promoting composition is also formulated to minimize the crash effect common to stimulants such as energy drinks.
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公开(公告)号：US11896565B2
公开(公告)日：2024-02-13
申请号：US17557429
申请日：2021-12-21
发明人： Gary Millet
IPC分类号： A61K31/19 , A61K31/593 , A23L33/12 , A61P3/00 , A61K47/14 , A23L33/16 , A23L33/175 , A61K9/00 , A61K9/02 , A61K9/14 , A61K9/20 , A61K9/48 , A61K47/10
CPC分类号： A61K31/19 , A23L33/12 , A23L33/16 , A23L33/175 , A61K9/006 , A61K9/0019 , A61K9/0053 , A61K9/0095 , A61K9/02 , A61K9/14 , A61K9/145 , A61K9/2004 , A61K9/2013 , A61K9/4841 , A61K9/4858 , A61K47/10 , A61K47/14 , A61P3/00 , A23V2002/00 , A23V2200/30 , A23V2250/02 , A23V2250/1876 , A23V2250/1878 , A23V2250/1884 , A23V2002/00 , A23V2200/30 , A23V2250/06 , A23V2250/1578 , A23V2250/16 , A23V2250/161 , A23V2250/1614 , A23V2250/1878 , A23V2250/1884
摘要： Ketogenic compositions including a plurality of beta-hydroxybutyrate (BHB) salts are formulated to induce or sustain ketosis in a subject to which the ketogenic compositions are administered. The BHB mixed salt is formulated to provide a biologically balanced set of cationic electrolytes and avoid detrimental health effects associated with imbalanced electrolyte ratios. A ketogenic composition includes BHB salts selected from sodium, potassium, calcium, and magnesium salts. The BHB composition may also include transition metal cations (e.g., zinc or iron), one or more BHB-amino acid salts, one or more ketone precursors, supplements, or other compounds that cause a rise in blood ketone levels without adding more electrolytes to the bloodstream, a short-, medium-, or long-chain fatty acid source, vitamins, minerals, flavorants, or other excipients.
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公开(公告)号：US20220062216A1
公开(公告)日：2022-03-03
申请号：US17394649
申请日：2021-08-05
发明人： Gary Millet
摘要： Disclosed herein are “ketone body-HMB” or “KB-HMB” compositions including a combination of: (1) hydroxymethyl butyrate; (2) a ketone body component such as beta-hydroxybutyrate (BHB) and/or acetoacetate; and (3) optionally a dietetically or pharmaceutically acceptable carrier. Also disclosed herein are methods of using such compositions for producing desired physiological effects, such as fat loss, in a mammal. The compositions beneficially enhance fat loss through ketosis while also reducing or eliminating muscle wasting and/or promoting muscle formation.
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