公开(公告)号：US20170158758A1

公开(公告)日：2017-06-08

申请号：US15359096

申请日：2016-11-22

Applicant: AbbVie, Inc.

Inventor： Natarajan RAMASUBRAMANYAN ,  Lihua YANG ,  Matthew HERIGSTAD ,  Hong YANG ,  Kartik SUBRAMANIAN ,  Xiaobei ZENG ,  Diane D. DONG ,  Wen Chung LIM ,  Kathreen A. GIFFORD ,  Zehra KAYMAKCALAN ,  Christopher CHUMSAE

IPC: C07K16/24 ,  A61K47/18 ,  A61K47/26 ,  A61K39/395

CPC classification number: C07K16/241 ,  A61K39/39591 ,  A61K47/183 ,  A61K47/26 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/10 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/76

Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.