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公开(公告)号：US20150110799A1
公开(公告)日：2015-04-23
申请号：US14077871
申请日：2013-11-12
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew Omon HERIGSTAD , Hong YANG , Kartik SUBRAMANIAN , Xiaobei ZENG , Diane D. DONG , Wen Chung LIM , Kathreen A. GIFFORD , Zehra KAYMAKCALAN , Christopher CHUMSAE
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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Patent Agency Ranking
公开(公告)号：US20160194390A1
公开(公告)日：2016-07-07
申请号：US15009286
申请日：2016-01-28
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew Omon HERIGSTAD , Hong YANG , Kartik SUBRAMANIAN , Xiaobei ZENG , Diane D. DONG , Wen Chung LIM , Kathreen A. GIFFORD , Zehra KAYMAKCALAN , Christopher CHUMSAE
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US20170158758A1
公开(公告)日：2017-06-08
申请号：US15359096
申请日：2016-11-22
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew HERIGSTAD , Hong YANG , Kartik SUBRAMANIAN , Xiaobei ZENG , Diane D. DONG , Wen Chung LIM , Kathreen A. GIFFORD , Zehra KAYMAKCALAN , Christopher CHUMSAE
IPC: C07K16/24 , A61K47/18 , A61K47/26 , A61K39/395
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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4.发明申请公开(公告)号：US20170121403A1
公开(公告)日：2017-05-04
申请号：US15353116
申请日：2016-11-16
Applicant: AbbVie, Inc.
Inventor： Kartik SUBRAMANIAN , Mayda Perez THIELE , Xiaobei ZENG , Chee Furng WONG , Zehra KAYMAKCALAN , Ying JING , Christopher M. CHUMSAE
CPC classification number: C07K16/241 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C12P21/005
Abstract: The instant invention relates to modulated lysine variant species compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such modulated lysine variant species compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US20150166650A1
公开(公告)日：2015-06-18
申请号：US14584619
申请日：2014-12-29
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew Omon HERIGSTAD , Hong YANG , Kartik SUBRAMANIAN , Xiaobei ZENG , Diane D. DONG , Wen Chung LIM , Kathreen A. GIFFORD , Zehra KAYMAKCALAN , Christopher CHUMSAE
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US20150132801A1
公开(公告)日：2015-05-14
申请号：US14575691
申请日：2014-12-18
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew Omon HERIGSTAD , Hong YANG , Kartik SUBRAMANIAN , Xiaobei ZENG , Diane D. DONG , Wen Chung LIM , Kathreen A. GIFFORD , Zehra KAYMAKCALAN , Christopher CHUMSAE
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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