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公开(公告)号：US20150110799A1
公开(公告)日：2015-04-23
申请号：US14077871
申请日：2013-11-12
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew Omon HERIGSTAD , Hong YANG , Kartik SUBRAMANIAN , Xiaobei ZENG , Diane D. DONG , Wen Chung LIM , Kathreen A. GIFFORD , Zehra KAYMAKCALAN , Christopher CHUMSAE
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US20150166650A1
公开(公告)日：2015-06-18
申请号：US14584619
申请日：2014-12-29
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew Omon HERIGSTAD , Hong YANG , Kartik SUBRAMANIAN , Xiaobei ZENG , Diane D. DONG , Wen Chung LIM , Kathreen A. GIFFORD , Zehra KAYMAKCALAN , Christopher CHUMSAE
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US20170158758A1
公开(公告)日：2017-06-08
申请号：US15359096
申请日：2016-11-22
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew HERIGSTAD , Hong YANG , Kartik SUBRAMANIAN , Xiaobei ZENG , Diane D. DONG , Wen Chung LIM , Kathreen A. GIFFORD , Zehra KAYMAKCALAN , Christopher CHUMSAE
IPC: C07K16/24 , A61K47/18 , A61K47/26 , A61K39/395
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US20160251425A1
公开(公告)日：2016-09-01
申请号：US15149898
申请日：2016-05-09
Applicant: AbbVie Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew Omon HERIGSTAD , Hong YANG , Christopher CHUMSAE
IPC: C07K16/24 , C07K1/22 , C07K1/18 , A61K39/395 , C07K1/16
CPC classification number: C07K16/241 , A61K39/39591 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.
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公开(公告)号：US20160194390A1
公开(公告)日：2016-07-07
申请号：US15009286
申请日：2016-01-28
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew Omon HERIGSTAD , Hong YANG , Kartik SUBRAMANIAN , Xiaobei ZENG , Diane D. DONG , Wen Chung LIM , Kathreen A. GIFFORD , Zehra KAYMAKCALAN , Christopher CHUMSAE
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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Patent Agency Ranking
公开(公告)号：US20150141623A1
公开(公告)日：2015-05-21
申请号：US14584492
申请日：2014-12-29
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew Omon HERIGSTAD , Hong YANG , Christopher CHUMSAE
CPC classification number: C07K16/241 , A61K39/39591 , C07K1/165 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/00 , C07K2317/14 , C07K2317/21 , C12P21/00
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.
Abstract translation: 本发明涉及蛋白质生产和纯化领域，特别涉及用于控制目标蛋白质的电荷变体，聚集体和片段的量以及存在于纯化制剂中的宿主细胞蛋白的组合物和方法， 在这种蛋白质纯化期间应用特定的色谱条件。
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公开(公告)号：US20150140006A1
公开(公告)日：2015-05-21
申请号：US14614311
申请日：2015-02-04
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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公开(公告)号：US20190062419A1
公开(公告)日：2019-02-28
申请号：US15951560
申请日：2018-04-12
Applicant: AbbVie Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew Omon HERIGSTAD , Hong YANG , Christopher CHUMSAE
Abstract: The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.
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9.发明申请公开(公告)号：US20150259410A1
公开(公告)日：2015-09-17
申请号：US14714113
申请日：2015-05-15
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua Yang , Matthew Omon Herigstad , Hong Yang , Kartik Subramanian , Xiaobei Zeng , Diane D. Dong , Wen Chung Lim , Kathreen A. Gifford , Zehra Kaymakcalan , Christopher Chumsae
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
Abstract translation: 本发明涉及包含蛋白质例如抗体或其抗原结合部分的低酸性物质（AR）组合物，以及用于产生这种低AR组合物的方法，例如细胞培养和/或蛋白质纯化方法。 还提供了使用这种组合物治疗病症（例如其中TNFα有害的病症）的方法。
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公开(公告)号：US20150132801A1
公开(公告)日：2015-05-14
申请号：US14575691
申请日：2014-12-18
Applicant: AbbVie, Inc.
Inventor： Natarajan RAMASUBRAMANYAN , Lihua YANG , Matthew Omon HERIGSTAD , Hong YANG , Kartik SUBRAMANIAN , Xiaobei ZENG , Diane D. DONG , Wen Chung LIM , Kathreen A. GIFFORD , Zehra KAYMAKCALAN , Christopher CHUMSAE
IPC: C07K16/24
CPC classification number: C07K16/241 , A61K39/39591 , A61K47/183 , A61K47/26 , A61K2039/505 , C07K16/00 , C07K2317/10 , C07K2317/14 , C07K2317/21 , C07K2317/41 , C07K2317/76
Abstract: The instant invention relates to low acidic species (AR) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods, e.g., cell culture and/or protein purification methods, for producing such low AR compositions. Methods for using such compositions to treat a disorder, e.g., a disorder in which TNFα is detrimental, are also provided.
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