公开(公告)号：US20170158693A1

公开(公告)日：2017-06-08

申请号：US15435553

申请日：2017-02-17

申请人： AbbVie Deutschland GmbH & Co. KG ,  AbbVie Inc.

发明人： Gisela BACKFISCH ,  Margaretha Henrica Maria BAKKER ,  Günter BLAICH ,  Wilfried BRAJE ,  Karla DRESCHER ,  Thomas ERHARD ,  Andreas HAUPT ,  Hannes KOOLMAN ,  Viktor LAKICS ,  Anna LINSENMEIER ,  Helmut MACK ,  Raimund PETER ,  Ana Lucia RELO ,  Xiaona ZHAO ,  Jincheng WANG

IPC分类号： C07D471/06

CPC分类号： C07D471/06 ,  C07D471/04

摘要： The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a cyclic substituent, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor, and processes for preparing such compounds and compositions.

公开(公告)号：US20150259343A1

公开(公告)日：2015-09-17

申请号：US14657840

申请日：2015-03-13

申请人： AbbVie Deutschland GmbH & Co. KG

发明人： Gisela BACKFISCH ,  Margaretha Henrica Maria BAKKER ,  Günter BLAICH ,  Wilfried BRAJE ,  Karla DRESCHER ,  Thomas ERHARD ,  Andreas HAUPT ,  Hannes KOOLMAN ,  Viktor LAKICS ,  Anna LINSENMEIER ,  Helmut MACK ,  Raimund PETER ,  Ana Lucia RELO

IPC分类号： C07D471/06

CPC分类号： C07D471/06 ,  C07D471/04

摘要： The present invention relates to tricyclic hexahydrodiazepinoquinolines carrying a cyclic substituent, to a method for producing them, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor, and processes for preparing such compounds and compositions.

摘要翻译： 本发明涉及携带环状取代基的三环六氢二氮杂喹啉，其制备方法，含有这些化合物的药物组合物，其用作5-HT 2C受体的调节剂，特别是激动剂或部分激动剂，其用于制备 用于预防或治疗对5-HT 2C受体的调节作出反应的病症和障碍的药物，用于预防或治疗对5-HT 2C受体调节作用的病症和障碍的方法，以及制备这种化合物的方法和 组合物。