公开(公告)号：US20210147381A1

公开(公告)日：2021-05-20

申请号：US16630813

申请日：2018-07-16

申请人： AbbVie Deutschland GmbH & Co. KG

发明人： Wilhelm AMBERG ,  Hervé GENESTE ,  Wilfried HORNBERGER ,  Udo LANGE ,  Mario MEZLER ,  Michael OCHSE ,  Frank OELLIEN ,  Sean C. TURNER ,  Jeroen VAN BERGEIJK ,  Elizabeth VAN DER KAM

IPC分类号： C07D401/06 ,  C07D217/02 ,  C07D409/06

摘要： The invention relates to 1,2,3,4-substituted quinoline compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.

公开(公告)号：US20200055817A1

公开(公告)日：2020-02-20

申请号：US16346642

申请日：2017-11-02

申请人： AbbVie Deutschland GmbH & Co. KG

发明人： Wilhelm AMBERG ,  Jeroen VAN BERGEIJK ,  Herve GENESTE ,  Wilfried HORNBERGER ,  Elizabeth Louise VAN DER KAM ,  Udo LANGE ,  Mario MEZLER ,  Michael OCHSE ,  Frank OELLIEN ,  Patrick WALLESER ,  Sean C. TURNER

IPC分类号： C07D205/12 ,  C07D405/12 ,  C07D401/10 ,  C07D403/12 ,  C07D491/107 ,  C07D221/20

摘要： The invention relates to heterocyclic compounds of formula (I) as SIP modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment or alleviation of diseases or disorders mediated by an SIP receptor.