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公开(公告)号：US20210147381A1
公开(公告)日：2021-05-20
申请号：US16630813
申请日：2018-07-16
发明人： Wilhelm AMBERG , Hervé GENESTE , Wilfried HORNBERGER , Udo LANGE , Mario MEZLER , Michael OCHSE , Frank OELLIEN , Sean C. TURNER , Jeroen VAN BERGEIJK , Elizabeth VAN DER KAM
IPC分类号： C07D401/06 , C07D217/02 , C07D409/06
摘要： The invention relates to 1,2,3,4-substituted quinoline compounds as S1P modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment, alleviation or prevention of diseases or disorders mediated by an S1P receptor.
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2.发明申请ISOINDOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权ISOINDOLINE衍生物，含有它们的药物组合物及其在治疗中的使用公开(公告)号：US20130210880A1
公开(公告)日：2013-08-15
申请号：US13764454
申请日：2013-02-11
发明人： Wilhelm Amberg , Udo LANGE , Michael OCHSE , Frauke POHLKI , Charles W. HUTCHINS , Irini ZANZE , Hongyu H. ZHAO , Huan-Qiu LI , Ying X. WANG
IPC分类号： C07D209/46 , C07D405/14 , C07D403/12
CPC分类号： C07D209/46 , C07D209/44 , C07D403/12 , C07D405/14
摘要： The present invention relates to isoindoline derivatives of the formula (I) or a physiologically tolerated salt thereof.The present invention also relates to pharmaceutical compositions comprising such isoindoline derivatives, and the use of such isoindoline derivatives for therapeutic purposes.
摘要翻译： 本发明涉及式（I）的异二氢吲哚衍生物或其生理耐受盐。 本发明还涉及包含这种异二氢吲哚衍生物的药物组合物，以及用于治疗目的的这种异吲哚啉衍生物的用途。
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公开(公告)号：US20200055817A1
公开(公告)日：2020-02-20
申请号：US16346642
申请日：2017-11-02
发明人： Wilhelm AMBERG , Jeroen VAN BERGEIJK , Herve GENESTE , Wilfried HORNBERGER , Elizabeth Louise VAN DER KAM , Udo LANGE , Mario MEZLER , Michael OCHSE , Frank OELLIEN , Patrick WALLESER , Sean C. TURNER
IPC分类号： C07D205/12 , C07D405/12 , C07D401/10 , C07D403/12 , C07D491/107 , C07D221/20
摘要： The invention relates to heterocyclic compounds of formula (I) as SIP modulators, pharmaceutical compositions comprising such compounds, and uses thereof in the treatment or alleviation of diseases or disorders mediated by an SIP receptor.
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4.发明申请N-SUBSTITUTED AMINOBENZOCYCLOHEPTENE, AMINOTETRALINE, AMINOINDANE AND PHENALKYLAMINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权N-取代的氨基苯甲酸，氨基嘌呤，氨基丁酸和苯丙氨酸衍生物，含有它们的药物组合物及其在治疗中的使用公开(公告)号：US20130131132A1
公开(公告)日：2013-05-23
申请号：US13680488
申请日：2012-11-19
IPC分类号： C07D403/12 , C07D305/08
CPC分类号： C07D403/12 , C07D233/84 , C07D305/08
摘要： The present invention relates to N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives of the formula (I), (II), (III) or (IV) or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives, and the use of such N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives for therapeutic purposes. The N-substituted aminobenzocycloheptene, aminotetraline, aminoindane and phenalkylamine derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I），（II），（III）或（IV）的N-取代氨基苯并环庚三烯，氨基三氢化萘，氨基茚满和苯烷基胺衍生物或其生理上耐受的盐。 本发明涉及包含这种N-取代的氨基苯并环庚烯，氨基四氢化萘，氨基茚满和苯烷基胺衍生物的药物组合物，以及用于治疗目的的这种N-取代氨基苯并环庚烯，氨基四氢化萘，氨基茚满和苯烷基胺衍生物的用途。 N-取代的氨基苯并环庚三烯，氨基四氢化萘，氨基茚满和苯烷基胺衍生物是GlyT1抑制剂。
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