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1.发明授权公开(公告)号：US09650334B2
公开(公告)日：2017-05-16
申请号：US14215533
申请日：2014-03-17
发明人： Wilhelm Amberg , Frauke Pohlki , Udo Lange , Ying X. Wang , Hongyu H. Zhao , Huan-Qiu Li , Jason T. Brewer , Irini Zanze , Justin Dietrich , Anil Vasudevan , Stevan W. Djuric , Yanbin Lao , Charles W. Hutchins
IPC分类号： A61K31/4025 , A61K31/44 , A61K31/4178 , C07D207/09 , C07D403/12 , C07D401/12 , C07D207/48 , C07D401/14 , C07D403/14 , C07D405/14 , C07D487/10 , C07D417/14 , C07D409/14 , C07D495/04 , C07D471/04 , C07D487/04
CPC分类号： C07D207/09 , A61K31/4025 , A61K31/44 , C07D207/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D495/04
摘要： The present invention relates to pyrrolidine derivatives of the formula (I), or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such pyrrolidine derivatives, and the use of such pyrrolidine derivatives for therapeutic purposes. The pyrrolidine derivatives are GlyT1 inhibitors.
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2.发明申请公开(公告)号：US20140275086A1
公开(公告)日：2014-09-18
申请号：US14215533
申请日：2014-03-17
发明人： Wilhelm Amberg , Frauke Pohlki , Udo Lange , Ying X. Wang , Hongyu H. Zhao , Huan-Qiu Li , Jason T. Brewer , Irini Zanze , Justin Dietrich , Anil Vasudevan , Stevan W. Djuric , Yanbin Lao , Charles W. Hutchins
IPC分类号： C07D207/09 , C07D401/12 , C07D207/48 , C07D401/14 , C07D403/14 , C07D487/04 , C07D487/10 , C07D417/14 , C07D409/14 , C07D495/04 , C07D471/04 , C07D403/12 , C07D405/14
CPC分类号： C07D207/09 , A61K31/4025 , A61K31/44 , C07D207/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D487/10 , C07D495/04
摘要： The present invention relates to pyrrolidine derivatives of the formula (I), or a physiologically tolerated salt thereof.The invention relates to pharmaceutical compositions comprising such pyrrolidine derivatives, and the use of such pyrrolidine derivatives for therapeutic purposes. The pyrrolidine derivatives are GlyT1 inhibitors.
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3.发明授权Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy 有权异二氢吲哚衍生物，含有它们的药物组合物及其在治疗中的应用公开(公告)号：US09365512B2
公开(公告)日：2016-06-14
申请号：US13764454
申请日：2013-02-11
发明人： Wilhelm Amberg , Udo Lange , Michael Ochse , Frauke Pohlki , Charles W. Hutchins , Irini Zanze , Hongyu H. Zhao , Huan-Qiu Li , Ying X. Wang
IPC分类号： C07D403/12 , C07D209/46 , C07D405/14 , C07D209/44
CPC分类号： C07D209/46 , C07D209/44 , C07D403/12 , C07D405/14
摘要： The present invention relates to isoindoline derivatives of the formula (I) or a physiologically tolerated salt thereof. The present invention also relates to pharmaceutical compositions comprising such isoindoline derivatives, and the use of such isoindoline derivatives for therapeutic purposes.
摘要翻译： 本发明涉及式（I）的异二氢吲哚衍生物或其生理上耐受的盐。 本发明还涉及包含这种异二氢吲哚衍生物的药物组合物，以及用于治疗目的的这种异吲哚啉衍生物的用途。
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4.发明授权公开(公告)号：US09656955B2
公开(公告)日：2017-05-23
申请号：US14216222
申请日：2014-03-17
发明人： Wilhelm Amberg , Frauke Pohlki , Udo Lange , Ying X. Wang , Hongyu H. Zhao , Huan-Qiu Li , Jason T. Brewer , Irini Zanze , Justin Dietrich , Anil Vasudevan , Stevan W. Djuric , Yanbin Lao , Charles W. Hutchins
IPC分类号： A61K31/4025 , A61K31/44 , A61K31/4178 , C07D207/09 , C07D403/12 , C07D401/12 , C07D207/48 , C07D401/14 , C07D403/14 , C07D405/14 , C07D487/10 , C07D417/14 , C07D409/14 , C07D495/04 , C07D471/04 , C07D487/04
CPC分类号： C07D207/48 , A61K31/4025 , A61K31/4178 , A61K31/44 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to pyrrolidine derivatives of the formula (I), or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such pyrrolidine derivatives, and the use of such pyrrolidine derivatives for therapeutic purposes. The pyrrolidine derivatives are GlyT1 inhibitors.
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5.发明申请PYRROLIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 有权吡咯烷衍生物，含有它们的药物组合物及其在治疗中的使用公开(公告)号：US20140275087A1
公开(公告)日：2014-09-18
申请号：US14216222
申请日：2014-03-17
发明人： Wilhelm Amberg , Frauke Pohlki , Udo Lange , Ying X. Wang , Hongyu H. Zhao , Huan-Qiu Li , Jason T. Brewer , Irini Zanze , Justin Dietrich , Anil Vasudevan , Stevan W. Djuric , Yanbin Lao , Charles W. Hutchins
IPC分类号： C07D207/48 , C07D403/14 , C07D401/14 , C07D403/12 , C07D401/12
CPC分类号： C07D207/48 , A61K31/4025 , A61K31/4178 , A61K31/44 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14
摘要： The present invention relates to pyrrolidine derivatives of the formula (I), or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such pyrrolidine derivatives, and the use of such pyrrolidine derivatives for therapeutic purposes. The pyrrolidine derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及式（I）的吡咯烷衍生物或其生理上耐受的盐。 本发明涉及包含这种吡咯烷衍生物的药物组合物以及这种吡咯烷衍生物用于治疗目的的用途。 吡咯烷衍生物是GlyT1抑制剂。
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