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公开(公告)号：US10118926B2
公开(公告)日：2018-11-06
申请号：US14026354
申请日：2013-09-13
发明人： Hannes Koolman , Wilfried Braje , Helmut Mack , Andreas Haupt , Ana Lucia Relo , Karla Drescher , Margaretha Henrica Maria Bakker , Viktor Lakics , Carolin Hoft , Ruxu Xu , Xiaona Zhao
IPC分类号： A61K31/551 , C07D471/06 , C07D487/16 , C07D487/06
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
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公开(公告)号：US20190071443A1
公开(公告)日：2019-03-07
申请号：US16179050
申请日：2018-11-02
发明人： Hannes Koolman , Wilfried Braje , Helmut Mack , Andreas Haupt , Ana Lucia Relo , Karla Drescher , Margaretha Henrica Maria Bakker , Viktor Lakics , Carolin Hoft , Ruxu Xu , Xiaona Zhao
IPC分类号： C07D471/06 , C07D487/16 , C07D487/06
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
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3.发明申请公开(公告)号：US20200039930A1
公开(公告)日：2020-02-06
申请号：US16496256
申请日：2018-03-20
发明人： Gisela Backfisch , Margaretha Henrica Maria Bakker , Lawrence Black , Wilfried Braje , Karla Drescher , Thomas Erhard , Andreas Haupt , Carolin Hoft , Andreas Kling , Viktor Lakics , Helmut Mack , Frank Oellien , Ana Lucia Relo
IPC分类号： C07D207/16
摘要： The present invention relates to proline amide compounds and their azetidine derivatives of formula I wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, to a method for preventing or treating conditions and disorders which respond to the modulation of the 5-HT2C receptor, and processes for preparing such compounds and compositions.
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公开(公告)号：US20200283439A1
公开(公告)日：2020-09-10
申请号：US16601075
申请日：2019-10-14
发明人： Hannes Koolman , Wilfried Braje , Helmut Mack , Andreas Haupt , Ana Lucia Relo , Karla Drescher , Margaretha Henrica Maria Bakker , Viktor Lakics , Carolin Hoft , Ruxu Xu , Xiaona Zhao
IPC分类号： C07D471/06 , C07D487/06 , C07D487/16
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
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公开(公告)号：US20140080816A1
公开(公告)日：2014-03-20
申请号：US14026354
申请日：2013-09-13
发明人： Hannes Koolman , Wilfried Braje , Helmut Mack , Andreas Haupt , Ana Lucia Relo , Karla Drescher , Margot Bakker , Viktor Lakics , Carolin Hoft , Ruxu Xu , Xiaona Zhao
IPC分类号： C07D471/06 , C07D487/16 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06 , C07D487/16
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
摘要翻译： 本发明涉及三环喹啉和喹喔啉衍生物，涉及含有这些化合物的药物组合物，其用作5-HT 2C受体的调节剂，特别是激动剂或部分激动剂，其用于制备用于预防或治疗 对5-HT 2C受体的调节作出反应的病症和障碍，以及用于预防或治疗对5-HT 2C受体调节作用的病症和障碍的方法。
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公开(公告)号：US20200002354A1
公开(公告)日：2020-01-02
申请号：US16559262
申请日：2019-09-03
发明人： Gisela Backfisch , Margaretha Henrica Maria Bakker , Günter Blaich , Wilfried Braje , Karla Drescher , Thomas Erhard , Andreas Haupt , Carolin Hoft , Viktor Lakics , Helmut Mack , Frank Oellien , Raimund Peter , Ana Lucia Relo
IPC分类号： C07D498/04 , C07D498/14
摘要： The present invention relates to compound of formula (I) wherein the variables are as defined in the claims and the description. The invention further relates to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, to their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to methods for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
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![Substituted [1,4]diazepino[6,7,1-ij]quinolines as serotonin 5-HT2C receptor modulators](/abs-image/US/2017/02/21/US09573950B2/abs.jpg.150x150.jpg)
7.发明授权Substituted [1,4]diazepino[6,7,1-ij]quinolines as serotonin 5-HT2C receptor modulators 有权取代的[1,4]二氮杂[6,7,1-ij]喹啉作为5-羟色胺5-HT 2C受体调节剂公开(公告)号：US09573950B2
公开(公告)日：2017-02-21
申请号：US14657840
申请日：2015-03-13
发明人： Gisela Backfisch , Margaretha Henrica Maria Bakker , Günter Blaich , Wilfried Braje , Karla Drescher , Thomas Erhard , Andreas Haupt , Hannes Koolman , Viktor Lakics , Anna Linsenmeier , Helmut Mack , Raimund Peter , Ana Lucia Relo , Xiaona Zhao , Jincheng Wang
IPC分类号： A61K31/551 , C07D487/16 , C07D471/06 , C07D471/04
CPC分类号： C07D471/06 , C07D471/04
摘要： The present invention relates to compound of formula (I) as tricyclic hexahydrodiazepinoquinolines carrying a cyclic substituent, useful for modulating the 5-HT2C receptor and preventing and/or treating conditions and disorders that respond to the modulation of the 5-HT2C receptor. The present invention also relates to methods for producing compounds of formula (I), pharmaceutical compositions containing such compounds, and methods for preventing or treating conditions and disorders that respond to the modulation of the 5-HT2C receptor by administering compounds of formula (1) or pharmaceutical compositions thereof.
摘要翻译： 本发明涉及具有环状取代基的三环六氢二氮杂喹啉的式（I）化合物，其可用于调节5-HT 2C受体，以及预防和/或治疗对5-HT 2C受体调节作用的病症和障碍。 本发明还涉及制备式（I）化合物的方法，含有这些化合物的药物组合物，以及通过给予式（1）化合物来预防或治疗对5-HT 2C受体调节作用的病症和障碍的方法， 或其药物组合物。
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公开(公告)号：US09994568B2
公开(公告)日：2018-06-12
申请号：US14868835
申请日：2015-09-29
发明人： Hannes Koolman , Wilfried Braje , Helmut Mack , Andreas Haupt , Ana Lucia Relo , Karla Drescher , Margaretha Henrica Maria Bakker , Viktor Lakics , Carolin Hoft
IPC分类号： A61K31/519 , A61K31/52 , C07D403/12 , C07D405/12 , C07D473/34 , C07D487/04 , C07D471/06 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
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公开(公告)号：US20160016954A1
公开(公告)日：2016-01-21
申请号：US14868835
申请日：2015-09-29
发明人： Hannes Koolman , Wilfried Braje , Helmut Mack , Andreas Haupt , Ana Lucia Relo , Karla Drescher , Margaretha Henrica Maria Bakker , Viktor Lakics , Carolin Hoft
IPC分类号： C07D471/06 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
摘要翻译： 本发明涉及三环喹啉和喹喔啉衍生物，涉及含有这些化合物的药物组合物，其用作5-HT 2C受体的调节剂，特别是激动剂或部分激动剂，其用于制备用于预防或治疗 对5-HT 2C受体的调节作出反应的病症和障碍，以及用于预防或治疗对5-HT 2C受体调节作用的病症和障碍的方法。
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公开(公告)号：US09169253B2
公开(公告)日：2015-10-27
申请号：US13838788
申请日：2013-03-15
发明人： Hannes Koolman , Wilfried Braje , Helmut Mack , Andreas Haupt , Ana Lucia Relo , Karla Drescher , Margaretha Henrica Maria Bakker , Viktor Lakics , Carolin Hoft
IPC分类号： C07D471/06 , C07D487/02 , C07D221/20 , C07D221/18 , C07D487/06
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention relates to tricyclic quinoline and quinoxaline derivatives, to a pharmaceutical composition containing such compounds, to their use as modulators, especially agonists or partial agonists, of the 5-HT2C receptor, their use for preparing a medicament for the prevention or treatment of conditions and disorders which respond to the modulation of 5-HT2C receptor, and to a method for preventing or treating conditions and disorders which respond to the modulation of 5-HT2C receptor.
摘要翻译： 本发明涉及三环喹啉和喹喔啉衍生物，涉及含有这些化合物的药物组合物，其用作5-HT 2C受体的调节剂，特别是激动剂或部分激动剂，其用于制备用于预防或治疗 对5-HT 2C受体的调节作出反应的病症和障碍，以及用于预防或治疗对5-HT 2C受体调节作用的病症和障碍的方法。
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