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    Solid dispersions containing an apoptosis-inducing agent
    2.
    发明授权
    Solid dispersions containing an apoptosis-inducing agent 有权

    公开(公告)号：US10213433B2

    公开(公告)日：2019-02-26

    申请号：US14537392

    申请日：2014-11-10

    Applicant: AbbVie Inc.

    Inventor： Nathaniel Catron ,  David Lindley ,  Jonathan M. Miller ,  Eric A. Schmitt ,  Ping Tong

    IPC: A61K31/397 ,  A61K31/5377 ,  A61K9/14 ,  A61K9/16 ,  A61K9/48 ,  A61K31/437 ,  A61K31/496

    Abstract: A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

    SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT
    5.
    发明申请
    SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT 审中-公开

    公开(公告)号：US20190275051A1

    公开(公告)日：2019-09-12

    申请号：US16239199

    申请日：2019-01-03

    Applicant: AbbVie Inc.

    Inventor： Nathaniel Catron ,  David Lindley ,  Jonathan M. Miller ,  Eric A. Schmitt ,  Ping Tong

    IPC: A61K31/5377 ,  A61K9/48 ,  A61K31/496 ,  A61K31/437 ,  A61K9/14 ,  A61K9/16

    Abstract: A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

    SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT
    6.
    发明申请
    SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT 有权

    公开(公告)号：US20250161318A1

    公开(公告)日：2025-05-22

    申请号：US18809439

    申请日：2024-08-20

    Applicant: AbbVie Inc.

    Inventor： Nathaniel Catron ,  David Lindley ,  Jonathan M. Miller ,  Eric A. Schmitt ,  Ping Tong

    IPC: A61K31/5377 ,  A61K9/14 ,  A61K9/16 ,  A61K9/48 ,  A61K31/437 ,  A61K31/496

    Abstract: A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

    SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT
    8.
    发明申请
    SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT 有权

    公开(公告)号：US20220125796A1

    公开(公告)日：2022-04-28

    申请号：US17341158

    申请日：2021-06-07

    Applicant: AbbVie Inc.

    Inventor： Nathaniel Catron ,  David Lindley ,  Jonathan M. Miller ,  Eric A. Schmitt ,  Ping Tong

    IPC: A61K31/5377 ,  A61K9/16 ,  A61K9/14 ,  A61K31/496 ,  A61K31/437 ,  A61K9/48

    Abstract: A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer.

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