公开(公告)号：US10508113B2

公开(公告)日：2019-12-17

申请号：US16299485

申请日：2019-03-12

Applicant: AbbVie Inc.

Inventor： Maria A. Argiriadi ,  Eric C. Breinlinger ,  Ellen Yulin Tsai Chien ,  Marlon D. Cowart ,  Kristine E. Frank ,  Michael M. Friedman ,  David J. Hardee ,  J. Martin Herold ,  Huaqing Liu ,  Wei Qiu ,  Marc J. Scanio ,  Michael R. Schrimpf ,  Thomas R. Vargo ,  Stacy A. Van Epps ,  Matthew P. Webster ,  Andrew J. Little ,  Matthew H. Katcher

IPC: C07D405/14 ,  C07D471/04

Abstract: Disclosed herein are compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4a, R4b, X1, X2, X3, X4, X5, nad n are as defined herein, pharmaeceutical compositions 2C X5, and n are as defined herein, pharmaceutical compositions comprising same, and methods of preparation and use.

公开(公告)号：US09382258B2

公开(公告)日：2016-07-05

申请号：US14693419

申请日：2015-04-22

Applicant: AbbVie Inc.

Inventor： Pramila A. Bhatia ,  John T. Randolph ,  Michael R. Schrimpf ,  Qingwei I. Zhang

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, treat pain; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

公开(公告)号：US08669255B2

公开(公告)日：2014-03-11

申请号：US13627541

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Tao Li ,  Sachin V. Patel ,  Richard J. Perner ,  John T. Randolph ,  Michael R. Schrimpf ,  Kevin R. Woller ,  Zhiren Xia ,  Qingwei Zhang

IPC: A61K31/495

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z 1，Z 2，Z 3，Z 4，R 1，R 2和R 3如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道抑制剂。

公开(公告)号：US08648074B2

公开(公告)日：2014-02-11

申请号：US13627536

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Tao Li ,  Sachin V. Patel ,  Richard J. Perner ,  John T. Randolph ,  Michael R. Schrimpf ,  Kevin R. Woller ,  Zhiren Xia ,  Qingwei Zhang

IPC: A61K31/495

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z′, Z″, L2, G2, R1, and R2 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel blockers.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z'，Z“，L2，G2，R1和R2如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道阻滞剂。

公开(公告)号：US20130085141A1

公开(公告)日：2013-04-04

申请号：US13627536

申请日：2012-09-26

Applicant: ABBVie Inc.

Inventor： Tao Li ,  Sachin V. Patel ,  Richard J. Perner ,  John T. Randolph ,  Michael R. Schrimpf ,  Kevin R. Woller ,  Zhiren Xia ,  Qingwei Zhang

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z′, Z″, L2, G2, R1, and R2 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel blockers.

Abstract translation: 本申请涉及：（a）式（I）化合物及其盐，其中Z'，Z“，L2，G2，R1和R2如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道阻滞剂。

公开(公告)号：US09983218B2

公开(公告)日：2018-05-29

申请号：US15454313

申请日：2017-03-09

Applicant: AbbVie Inc.

Inventor： Michael R. Schrimpf ,  Chih-hung Lee ,  Tao Li ,  Gregory Gfesser ,  Kathleen Mortell ,  Ramin Faghih ,  Diana L. Schmidt ,  Kevin Sippy ,  William H. Bunnelle ,  Marc Scanio ,  Lei Shi ,  Murali Gopalakrishnan ,  Diana L. Donnelly-Roberts ,  Min Hu

IPC: C07D471/18 ,  G01N33/68 ,  C07D487/10 ,  G01N33/50

CPC classification number: G01N33/6896 ,  C07D471/18 ,  C07D487/10 ,  G01N33/5058 ,  G01N2800/2814 ,  G01N2800/30

Abstract: The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.

公开(公告)号：US20130085142A1

公开(公告)日：2013-04-04

申请号：US13627541

申请日：2012-09-26

Applicant: AbbVie Inc.

Inventor： Tao Li ,  Sachin V. Patel ,  Richard J. Perner ,  John T. Randolph ,  Michael R. Schrimpf ,  Kevin R. Woller ,  Zhiren Xia ,  Qingwei Zhang

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: The present application relates to: (a) compounds of Formula (I): and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.

Abstract translation: 本申请涉及：（a）式（I）的化合物及其盐，其中Z 1，Z 2，Z 3，Z 4，R 1，R 2和R 3如说明书中所定义; （b）包含这些化合物和盐的组合物; 和（c）使用这些化合物，盐和组合物的方法，特别是用作钙通道抑制剂。

公开(公告)号：US20160022658A1

公开(公告)日：2016-01-28

申请号：US14877783

申请日：2015-10-07

Applicant: AbbVie Inc.

Inventor： Murali Gopalakrishnan ,  Marie P. Honore ,  Chih-Hung Lee ,  John Malysz ,  Jianguo Ji ,  Tao Li ,  Michael R. Schrimpf ,  Kevin B. Sippy ,  David J. Anderson

IPC: A61K31/4439 ,  A61K31/444 ,  G01N33/94 ,  C07D413/04 ,  C07D413/14 ,  A61K45/06 ,  A61K31/4427 ,  A61K31/4709

CPC classification number: A61K31/4439 ,  A61K31/4245 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/444 ,  A61K31/4709 ,  A61K45/06 ,  C07D413/04 ,  C07D413/14 ,  G01N33/944 ,  G01N2333/70571 ,  A61K2300/00

Abstract: The invention relates to a composition comprising a neuronal nicotinic receptor ligand and an α4β2 positive allosteric modulator, a method of using the same, and a related article of manufacture.

Abstract translation: 本发明涉及包含神经元烟碱性受体配体和α4和bgr2阳性变构调节剂，其使用方法和相关制品的组合物。

公开(公告)号：US20140171423A1

公开(公告)日：2014-06-19

申请号：US14101912

申请日：2013-12-10

Applicant: ABBVIE INC.

Inventor： Pramila A. Bhatia ,  John T. Randolph ,  Michael R. Schrimpf ,  Quinwei I. Zhang

IPC: C07D487/04

CPC classification number: C07D487/04

Abstract: This invention relates to: (a) compounds and salts thereof that, inter alia, treat pain; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

Abstract translation: 本发明涉及：（a）其特别是治疗疼痛的化合物及其盐; （b）可用于制备这些化合物和盐的中间体; （c）包含这些化合物和盐的组合物; （d）制备这种中间体，化合物，盐和组合物的方法; （e）使用这些化合物，盐和组合物的方法; 和（f）包含这些化合物，盐和组合物的试剂盒。

公开(公告)号：US20240158368A1

公开(公告)日：2024-05-16

申请号：US18379351

申请日：2023-10-12

Applicant: AbbVie Inc.

Inventor： David A. Degoey ,  Michael R. Schrimpf ,  David J. Hardee ,  Jacob Ludwig ,  Eric R. Miller ,  Timothy R. Hodges ,  Alberto Munoz ,  Sarah J. Perlmutter ,  Huan-Qiu X. Li ,  Alvin Jang ,  Elizabeth L. Noey ,  Gregory A. Gfesser ,  Edgars Jecs ,  Robert G. Schmidt ,  Justin D. Dietrich ,  Xenia B. Searle ,  Boguslaw P. Nocek ,  Andrew Bogdan

IPC: C07D401/12 ,  A61P31/14

CPC classification number: C07D401/12 ,  A61P31/14

Abstract: Pyrrolidine main protease inhibitors are described that are effective as antiviral compounds.