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公开(公告)号：US20150353552A1
公开(公告)日：2015-12-10
申请号：US14443294
申请日：2013-11-15
申请人： Abdelghani Abe ACHAB , Michael D. ALTMAN , Yongqi DENG , Timothy GUZI , Solomon KATTAR , Jason D. KATZ , Joey L. METHOT , Hua ZHOU , Meredeth MCGOWAN , Matthew P. CHRISTOPHER , Yudith GARCIA , Neville John THONY , Francesc Xavier FRADERA LLINAS , Changwei MU , Sixing ZHANG , Rong ZHANG , Kin Chiu FONG , Xiansheng LENG , MERCK SHARP & DOHME CORP.
发明人： Abdelghani Abe Achab , Michael D. Altman , Yongqi Deng , Timothy Guzi , Solomon Kattar , Jason D. Katz , Joey L. Methot , Hua Zhou , Meredeth McGowan , Matthew P. Christopher , Yudith Garcia , Neville John Anthony , Francesc Xavier Fradera Llinas , Kin Chiu Fong , Xiansheng Leng , Changwei Mu , Sixing Zhang , Rong Zhang
IPC分类号： C07D473/30 , A61K31/5377 , A61K31/52
CPC分类号： A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/00 , C07D473/06 , C07D473/30 , C07D473/38 , C07D519/00 , A61K2300/00
摘要： The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.
摘要翻译： 本发明提供了作为PI3K-δ抑制剂的式I化合物，因此可用于治疗PI3K-δ介导的疾病如炎症，哮喘，COPD和癌症。
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公开(公告)号：US20160207926A1
公开(公告)日：2016-07-21
申请号：US14443314
申请日：2013-11-15
发明人： Abdelghani Abe Achab , Michael D. Altman , Yongqi Deng , Solomon Kattar , Jason D. Katz , Joey L. Methot , Hua Zhou , Meredeth McGowan , Matthew P. Christopher , Yudith Garcia , Neville John Anthony , Francesc Xavier Fradera Llinas , Liping Yang , Changwei Mu , Xiaona Wang , Feng Shi , Baijun Ye , Sixing Zhang , Xiaoli Zhao , Rong Zhang , Kin Chiu Fong , Xiansheng Leng
IPC分类号： C07D487/04 , A61K31/55 , A61K31/5377 , A61K31/52 , C07D519/00
CPC分类号： C07D487/04 , A61K31/52 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D473/34 , C07D519/00 , A61K2300/00
摘要： The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflamation, asthma, COPD and cancer.
摘要翻译： 本发明提供了作为PI3K-δ抑制剂的式I化合物，因此可用于治疗PI3K-δ介导的疾病如炎症，哮喘，COPD和癌症。
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公开(公告)号：US09938281B2
公开(公告)日：2018-04-10
申请号：US14443314
申请日：2013-11-15
发明人： Abdelghani Abe Achab , Michael D. Altman , Yongqi Deng , Solomon Kattar , Jason D. Katz , Joey L. Methot , Hua Zhou , Meredeth McGowan , Matthew P. Christopher , Yudith Garcia , Neville John Anthony , Francesc Xavier Fradera Llinas , Liping Yang , Changwei Mu , Xiaona Wang , Feng Shi , Baijun Ye , Sixing Zhang , Xiaoli Zhao , Rong Zhang , Kin Chiu Fong , Xiansheng Leng
IPC分类号： A61K31/52 , A61K31/535 , C07D473/00 , C07D403/00 , C07D487/04 , C07D473/34 , A61K45/06 , A61K31/5377 , A61K31/55 , C07D519/00
CPC分类号： C07D487/04 , A61K31/52 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D473/34 , C07D519/00 , A61K2300/00
摘要： The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.
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公开(公告)号：US09730940B2
公开(公告)日：2017-08-15
申请号：US14443294
申请日：2013-11-15
发明人： Abdelghani Abe Achab , Michael D. Altman , Yongqi Deng , Timothy Guzi , Solomon Kattar , Jason D. Katz , Joey L. Methot , Hua Zhou , Meredeth McGowan , Matthew P. Christopher , Yudith Garcia , Neville John Anthony , Francesc Xavier Fradera Llinas , Kin Chiu Fong , Xiansheng Leng , Changwei Mu , Sixing Zhang , Rong Zhang
IPC分类号： A61K31/52 , C07D473/00 , C07D473/06 , C07D473/30 , C07D473/38 , C07D519/00 , A61K31/5377 , A61K45/06
CPC分类号： A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/00 , C07D473/06 , C07D473/30 , C07D473/38 , C07D519/00 , A61K2300/00
摘要： The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.
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