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1.发明申请公开(公告)号：US20210179607A1
公开(公告)日：2021-06-17
申请号：US16758717
申请日：2018-10-29
Applicant: Merck Sharp & Dohme Corp.
Inventor： Yongqi Deng , Abdelghani Achab , Bridget A. Becker , David Jonathan Bennett , Indu Bharathan , Xavier Fradera , Craig Gibeau , Yongxin Han , Derun Li , Kun Liu , Qinglin Pu , Sulagna Sanyal , David Sloman , Wensheng Yu , Hongjun Zhang
IPC: C07D471/04 , C07D215/14 , A61K45/06
Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号：US20180362482A1
公开(公告)日：2018-12-20
申请号：US16061597
申请日：2016-12-12
Applicant: Merck Sharp & Dohme Corp.
Inventor： Yongxin Han , Abdelghani Achab , Purakkattle Biju , Yongqi Deng , Xavier Fradera , Liangqin Guo , Shuwen He , Joseph Kozlowski , Ravi Kurukulasuriya , Kun Liu , Meredeth Ann McGowan , Qinglin Pu , Nunzio Sciammetta , Hongjun Zhang , Hua Zhou
IPC: C07D271/08 , C07D285/10 , C07D413/12 , A61P25/24 , A61P25/28 , A61P35/02 , A61P31/14 , A61P27/12 , A61P37/06
CPC classification number: C07D271/08 , A61P25/24 , A61P25/28 , A61P27/12 , A61P31/14 , A61P35/02 , A61P37/06 , C07D285/10 , C07D413/12 , C07D417/12 , C07F9/65318
Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号：US09957264B2
公开(公告)日：2018-05-01
申请号：US14778046
申请日：2014-03-19
Applicant: Merck Sharp & Dohme Corp.
Inventor： Matthew Lloyd Childers , Peter Fuller , David Guerin , Jason David Katz , Qinglin Pu , Mark E. Scott , Christopher F. Thompson , Michelle Martinez , Danielle Falcone , Luis Torres , Yongqi Deng , Ravi Kurukulasuriya , Hongbo Zeng , Yunfeng Bai , Norman Kong , Yumei Liu , Zhixiang Zheng
IPC: C07D471/04 , C07D519/00
CPC classification number: C07D471/04 , C07D519/00
Abstract: The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.
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公开(公告)号：US20200216425A1
公开(公告)日：2020-07-09
申请号：US16819325
申请日：2020-03-16
Applicant: Merck Sharp & Dohme Corp.
Inventor： Yongxin Han , Abdelghani Achab , Yongqi Deng , Xavier Fradera , Craig Gibeau , Brett A. Hopkins , Derun Li , Kun Liu , Meredeth A. McGowan , Nunzio Sciammetta , David Sloman , Catherine White , Hongjun Zhang , Hua Zhou
IPC: C07D405/10 , A61K31/4427 , A61K31/4965 , C07D241/12 , A61K31/501 , C07D417/14 , A61K31/4418 , C07D213/56 , C07D401/04 , C07D413/04 , A61K31/513 , A61K31/444 , C07D405/14 , A61K31/4184 , A61K31/4245 , A61K31/41 , A61K31/427 , C07D417/10 , A61K31/337 , C07D305/08 , A61K31/4155 , A61K31/506 , A61K31/437 , C07D471/04 , A61K45/06 , A61K31/4523 , C07D413/14 , C07D209/46 , A61P31/00 , C07D405/04 , C07D401/12 , C07D413/10 , A61P35/00 , C07D231/12 , A61P37/00 , C07D263/32
Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
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公开(公告)号：US20190144433A1
公开(公告)日：2019-05-16
申请号：US16186769
申请日：2018-11-12
Applicant: Merck Sharp & Dohme Corp.
Inventor： Yongxin Han , Abdelghani Achab , Yongqi Deng , Xavier Fradera , Craig Gibeau , Brett A. Hopkins , Derun Li , Kun Liu , Meredeth A. McGowan , Nunzio Sciammetta , David Sloman , Catherine White , Hongjun Zhang , Hua Zhou
IPC: C07D405/10 , A61K31/4427 , A61K45/06 , C07D471/04 , A61K31/437 , A61K31/506 , A61K31/4155 , C07D305/08 , A61K31/337 , C07D417/10 , A61K31/427 , A61K31/41 , A61K31/4245 , A61K31/4184 , C07D405/14 , A61K31/444 , A61K31/513 , C07D413/04 , C07D401/04 , C07D213/56 , A61K31/4418 , C07D417/14 , A61K31/501 , C07D241/12 , A61K31/4965 , A61K31/4523
Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
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Patent Agency Ranking
公开(公告)号：US09938281B2
公开(公告)日：2018-04-10
申请号：US14443314
申请日：2013-11-15
Applicant: Merck Sharp & Dohme Corp.
Inventor： Abdelghani Abe Achab , Michael D. Altman , Yongqi Deng , Solomon Kattar , Jason D. Katz , Joey L. Methot , Hua Zhou , Meredeth McGowan , Matthew P. Christopher , Yudith Garcia , Neville John Anthony , Francesc Xavier Fradera Llinas , Liping Yang , Changwei Mu , Xiaona Wang , Feng Shi , Baijun Ye , Sixing Zhang , Xiaoli Zhao , Rong Zhang , Kin Chiu Fong , Xiansheng Leng
IPC: A61K31/52 , A61K31/535 , C07D473/00 , C07D403/00 , C07D487/04 , C07D473/34 , A61K45/06 , A61K31/5377 , A61K31/55 , C07D519/00
CPC classification number: C07D487/04 , A61K31/52 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D473/34 , C07D519/00 , A61K2300/00
Abstract: The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.
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公开(公告)号：US09730940B2
公开(公告)日：2017-08-15
申请号：US14443294
申请日：2013-11-15
Applicant: Merck Sharp & Dohme Corp.
Inventor： Abdelghani Abe Achab , Michael D. Altman , Yongqi Deng , Timothy Guzi , Solomon Kattar , Jason D. Katz , Joey L. Methot , Hua Zhou , Meredeth McGowan , Matthew P. Christopher , Yudith Garcia , Neville John Anthony , Francesc Xavier Fradera Llinas , Kin Chiu Fong , Xiansheng Leng , Changwei Mu , Sixing Zhang , Rong Zhang
IPC: A61K31/52 , C07D473/00 , C07D473/06 , C07D473/30 , C07D473/38 , C07D519/00 , A61K31/5377 , A61K45/06
CPC classification number: A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/00 , C07D473/06 , C07D473/30 , C07D473/38 , C07D519/00 , A61K2300/00
Abstract: The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.
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公开(公告)号：US20150353552A1
公开(公告)日：2015-12-10
申请号：US14443294
申请日：2013-11-15
Applicant: Abdelghani Abe ACHAB , Michael D. ALTMAN , Yongqi DENG , Timothy GUZI , Solomon KATTAR , Jason D. KATZ , Joey L. METHOT , Hua ZHOU , Meredeth MCGOWAN , Matthew P. CHRISTOPHER , Yudith GARCIA , Neville John THONY , Francesc Xavier FRADERA LLINAS , Changwei MU , Sixing ZHANG , Rong ZHANG , Kin Chiu FONG , Xiansheng LENG , MERCK SHARP & DOHME CORP.
Inventor： Abdelghani Abe Achab , Michael D. Altman , Yongqi Deng , Timothy Guzi , Solomon Kattar , Jason D. Katz , Joey L. Methot , Hua Zhou , Meredeth McGowan , Matthew P. Christopher , Yudith Garcia , Neville John Anthony , Francesc Xavier Fradera Llinas , Kin Chiu Fong , Xiansheng Leng , Changwei Mu , Sixing Zhang , Rong Zhang
IPC: C07D473/30 , A61K31/5377 , A61K31/52
CPC classification number: A61K31/52 , A61K31/5377 , A61K45/06 , C07D473/00 , C07D473/06 , C07D473/30 , C07D473/38 , C07D519/00 , A61K2300/00
Abstract: The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflammation, asthma, COPD and cancer.
Abstract translation: 本发明提供了作为PI3K-δ抑制剂的式I化合物，因此可用于治疗PI3K-δ介导的疾病如炎症，哮喘，COPD和癌症。
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公开(公告)号：US10995085B2
公开(公告)日：2021-05-04
申请号：US16819325
申请日：2020-03-16
Applicant: Merck Sharp & Dohme Corp.
Inventor： Yongxin Han , Abdelghani Achab , Yongqi Deng , Xavier Fradera , Craig Gibeau , Brett A. Hopkins , Derun Li , Kun Liu , Meredeth A. McGowan , Nunzio Sciammetta , David Sloman , Catherine White , Hongjun Zhang , Hua Zhou
IPC: C07D405/10 , A61K31/4523 , A61K45/06 , C07D471/04 , A61K31/437 , A61K31/506 , A61K31/4155 , C07D305/08 , A61K31/337 , C07D417/10 , A61K31/427 , A61K31/41 , A61K31/4245 , A61K31/4184 , C07D405/14 , A61K31/444 , A61K31/513 , C07D413/04 , C07D401/04 , C07D213/56 , A61K31/4418 , C07D417/14 , A61K31/501 , C07D241/12 , A61K31/4965 , A61K31/4427 , C07D263/32 , A61P37/00 , C07D231/12 , A61P35/00 , C07D413/10 , C07D401/12 , C07D405/04 , A61P31/00 , C07D209/46 , C07D413/14
Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.
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10.发明申请公开(公告)号：US20200231606A1
公开(公告)日：2020-07-23
申请号：US16326408
申请日：2017-08-24
Applicant: Merck Sharp & Dohme Corp.
Inventor： Kun Liu , Abdelghani Achab , Purakkattle Biju , Timothy A. Cernak , Yongqi Deng , Xavier Fradera , Liangqin Guo , Yongxin Han , Shuwen He , Joseph Kozlowski , Derun Li , Guoqing Li , Qinglin Pu , Zhi-Cai Shi , Wensheng Yu , Hongjun Zhang
IPC: C07F5/02 , C07D271/08 , C07D413/12
Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Formula (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
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