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1.发明申请METHOD AND APPARATUS FOR CONTROLLING NEUROSTIMULATION ACCORDING TO PHYSICAL STATE 审中-公开用于根据物理状态控制神经元的方法和装置公开(公告)号：US20130226264A1
公开(公告)日：2013-08-29
申请号：US13858405
申请日：2013-04-08
申请人： Abhi V. Chavan , Keith R. Maile , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann
发明人： Abhi V. Chavan , Keith R. Maile , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36135
摘要： A neurostimulation system senses a signal indicative of a patient's physical state such as posture and/or activity level. In various embodiments, a stored value for each of stimulation parameters controlling delivery of neurostimulation is selected according to the patient's physical state. In various embodiments, values of the stimulation parameters are approximately optimized for each of a number of different physical states, and are stored for later selection.
摘要翻译： 神经刺激系统感测指示患者的身体状态（例如姿势和/或活动水平）的信号。 在各种实施例中，根据患者的身体状态选择控制神经刺激传递的每个刺激参数的存储值。 在各种实施例中，刺激参数的值针对多个不同物理状态中的每一个近似优化，并且被存储以供稍后选择。
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2.发明申请METHOD AND APPARATUS FOR CONTROLLING NEUROSTIMULATION ACCORDING TO PHYSICAL STATE 有权用于根据物理状态控制神经元的方法和装置公开(公告)号：US20120095530A1
公开(公告)日：2012-04-19
申请号：US13272786
申请日：2011-10-13
申请人： Abhi V. Chavan , Keith R. Maile , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann
发明人： Abhi V. Chavan , Keith R. Maile , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann
IPC分类号： A61N1/372
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36135
摘要： A neurostimulation system senses a signal indicative of a patient's physical state such as posture and/or activity level. In various embodiments, a stored value for each of stimulation parameters controlling delivery of neurostimulation is selected according to the patient's physical state. In various embodiments, values of the stimulation parameters are approximately optimized for each of a number of different physical states, and are stored for later selection.
摘要翻译： 神经刺激系统感测指示患者的身体状态（例如姿势和/或活动水平）的信号。 在各种实施例中，根据患者的身体状态选择控制神经刺激传递的每个刺激参数的存储值。 在各种实施例中，刺激参数的值针对多个不同物理状态中的每一个近似优化，并且被存储以供稍后选择。
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公开(公告)号：US08433419B2
公开(公告)日：2013-04-30
申请号：US13272786
申请日：2011-10-13
申请人： Abhi V. Chavan , Keith R. Maile , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann
发明人： Abhi V. Chavan , Keith R. Maile , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann
IPC分类号： A61N1/00
CPC分类号： A61N1/36139 , A61N1/36053 , A61N1/36135
摘要： A neurostimulation system senses a signal indicative of a patient's physical state such as posture and/or activity level. In various embodiments, a stored value for each of stimulation parameters controlling delivery of neurostimulation is selected according to the patient's physical state. In various embodiments, values of the stimulation parameters are approximately optimized for each of a number of different physical states, and are stored for later selection.
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公开(公告)号：US20110313488A1
公开(公告)日：2011-12-22
申请号：US13155549
申请日：2011-06-08
申请人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
发明人： Juan Gabriel Hincapie Ordonez , Stephen Ruble , Jason J. Hamann , Eric A. Mokelke , Shantha Arcot-Krishnamurthy , Kevin John Stalsberg , David J. Ternes
IPC分类号： A61N1/36
CPC分类号： A61N1/36142 , A61N1/36114 , A61N1/36139 , A61N1/36146
摘要： Various neural stimulator embodiments comprise controller circuitry, neural stimulation output circuitry, sensor circuitry and a memory. The neural stimulation output circuitry is configured to deliver the neural stimulation. The controller circuitry is configured to control stimulation parameters of the neural stimulation delivered by the neural stimulation output circuitry. The sensor circuitry, including at least one sensor, is configured to sense a response to the neural stimulation. The controller is configured to communicate with the sensor circuitry. The memory has instructions stored therein, operable on by the controller circuitry. The instructions include instructions for delivering neural stimulation using the neural stimulation output circuitry, instructions for controlling a titration sweep wherein the titration sweep varies stimulation parameter values, and instructions for monitoring a response to the titration sweep and automatically selecting stimulation parameters that provide an efficacious neural stimulation and provide a desirable safety margin to prevent injury to neural tissue.
摘要翻译： 各种神经刺激器实施例包括控制器电路，神经刺激输出电路，传感器电路和存储器。 神经刺激输出电路被配置为递送神经刺激。 控制器电路被配置为控制由神经刺激输出电路传递的神经刺激的刺激参数。 包括至少一个传感器的传感器电路被配置为感测对神经刺激的响应。 控制器被配置为与传感器电路通信。 存储器具有存储在其中的指令，可由控制器电路操作。 说明书包括使用神经刺激输出电路递送神经刺激的指令，用于控制滴定扫描的指令，其中滴定扫描改变刺激参数值，以及用于监测对滴定扫描的响应的指令，并自动选择提供有效神经元的刺激参数 刺激并提供理想的安全余量以防止对神经组织的损伤。
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5.发明申请公开(公告)号：US20110313483A1
公开(公告)日：2011-12-22
申请号：US13156879
申请日：2011-06-09
CPC分类号： A61N1/36139 , A61B5/04001 , A61B5/4041 , A61B5/4047 , A61B5/4058 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36135 , A61N1/36167
摘要： A neurostimulation system provides for capture verification and stimulation intensity adjustment to ensure effectiveness of vagus nerve stimulation in modulating one or more target functions in a patient. In various embodiments, stimulation is applied to the vagus nerve, and evoked responses are detected to verify that the stimulation captures the vagus nerve and to adjust one or more stimulation parameters that control the stimulation intensity.
摘要翻译： 神经刺激系统提供捕获验证和刺激强度调节，以确保迷走神经刺激在调节患者体内的一个或多个目标功能方面的有效性。 在各种实施例中，对迷走神经施加刺激，并且检测诱发反应以验证刺激捕获迷走神经并调节控制刺激强度的一个或多个刺激参数。
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6.发明授权公开(公告)号：US08972022B2
公开(公告)日：2015-03-03
申请号：US13156879
申请日：2011-06-09
CPC分类号： A61N1/36139 , A61B5/04001 , A61B5/4041 , A61B5/4047 , A61B5/4058 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36135 , A61N1/36167
摘要： A neurostimulation system provides for capture verification and stimulation intensity adjustment to ensure effectiveness of vagus nerve stimulation in modulating one or more target functions in a patient. In various embodiments, stimulation is applied to the vagus nerve, and evoked responses are detected to verify that the stimulation captures the vagus nerve and to adjust one or more stimulation parameters that control the stimulation intensity.
摘要翻译： 神经刺激系统提供捕获验证和刺激强度调节，以确保迷走神经刺激在调节患者体内的一个或多个目标功能方面的有效性。 在各种实施例中，对迷走神经施加刺激，并且检测诱发反应以验证刺激捕获迷走神经并调节控制刺激强度的一个或多个刺激参数。
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7.发明申请公开(公告)号：US20120271382A1
公开(公告)日：2012-10-25
申请号：US13453279
申请日：2012-04-23
申请人： Shantha Arcot-Krishnamurthy , Stephen Ruble , Jason J. Hamann , Juan Gabriel Hincapie Ordonez , David J. Ternes
发明人： Shantha Arcot-Krishnamurthy , Stephen Ruble , Jason J. Hamann , Juan Gabriel Hincapie Ordonez , David J. Ternes
IPC分类号： A61N1/36
CPC分类号： A61N1/36185 , A61N1/36053 , A61N1/3611 , A61N1/36132 , A61N1/36135
摘要： Some embodiments provide a method, comprising performing a neural stimulation test routine for stimulating a neural target in a cervical region of a patient, wherein for each of a plurality of head positions, performing the neural stimulation test routine includes testing a plurality of electrode configurations. The method further comprises recording threshold data for each of the tested electrode configurations for the plurality of head positions, and recommending an electrode configuration based on the recorded threshold data.
摘要翻译： 一些实施例提供了一种方法，包括执行用于刺激患者的子宫颈区域中的神经靶标的神经刺激测试程序，其中对于多个头部位置中的每一个，执行神经刺激测试程序包括测试多个电极配置。 该方法还包括记录针对多个头部位置的每个测试电极配置的阈值数据，以及基于记录的阈值数据推荐电极配置。
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8.发明授权公开(公告)号：US09314627B2
公开(公告)日：2016-04-19
申请号：US13453279
申请日：2012-04-23
申请人： Shantha Arcot-Krishnamurthy , Stephen Ruble , Jason J. Hamann , Juan Gabriel Hincapie Ordonez , David J. Ternes
发明人： Shantha Arcot-Krishnamurthy , Stephen Ruble , Jason J. Hamann , Juan Gabriel Hincapie Ordonez , David J. Ternes
IPC分类号： A61N1/36
CPC分类号： A61N1/36185 , A61N1/36053 , A61N1/3611 , A61N1/36132 , A61N1/36135
摘要： Some embodiments provide a method, comprising performing a neural stimulation test routine for stimulating a neural target in a cervical region of a patient, wherein for each of a plurality of head positions, performing the neural stimulation test routine includes testing a plurality of electrode configurations. The method further comprises recording threshold data for each of the tested electrode configurations for the plurality of head positions, and recommending an electrode configuration based on the recorded threshold data.
摘要翻译： 一些实施例提供了一种方法，包括执行用于刺激患者的子宫颈区域中的神经靶标的神经刺激测试程序，其中对于多个头部位置中的每一个，执行神经刺激测试程序包括测试多个电极配置。 该方法还包括记录针对多个头部位置的每个测试电极配置的阈值数据，以及基于记录的阈值数据推荐电极配置。
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9.发明申请METHOD AND APPARATUS FOR NEUROSTIMULATION WITH PREVENTION OF NEURAL ACCOMMODATION 审中-公开用于神经病学预防神经保护的方法和装置公开(公告)号：US20120296395A1
公开(公告)日：2012-11-22
申请号：US13472988
申请日：2012-05-16
IPC分类号： A61N1/36
CPC分类号： A61N1/36135 , A61N1/36053 , A61N1/36114 , A61N1/36167
摘要： A neurostimulation system delivers neurostimulation to a patient using one or more primary parameters and one or more secondary parameters. The one or more primary parameters are controlled for maintaining efficacy of the neurostimulation. The one or more secondary parameters are adjusted for preventing the patient from developing neural accommodation. In various embodiments, values for the one or more secondary parameters are varied during the delivery of the neurostimulation for prevention of neural accommodation that may result from a constant or periodic pattern of stimulation pulses.
摘要翻译： 神经刺激系统使用一个或多个主要参数和一个或多个次要参数向患者传递神经刺激。 控制一个或多个主要参数以保持神经刺激的功效。 调整一个或多个次要参数以防止患者发展神经调节。 在各种实施例中，在递送神经刺激期间改变一个或多个次要参数的值，以防止可能由刺激脉冲的恒定或周期性模式引起的神经调节。
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10.发明授权Methods and apparatus for controlling neurostimulation using evoked physiologic events 有权使用诱发生理事件控制神经刺激的方法和装置公开(公告)号：US09265431B2
公开(公告)日：2016-02-23
申请号：US13156891
申请日：2011-06-09
CPC分类号： A61N1/36139 , A61B5/04001 , A61B5/4041 , A61B5/4047 , A61B5/4058 , A61N1/36053 , A61N1/36071 , A61N1/36114 , A61N1/36117 , A61N1/36128 , A61N1/36135 , A61N1/36167
摘要： A neurostimulation system provides for capture verification and stimulation intensity adjustment to ensure effectiveness of vagus nerve stimulation in modulating one or more target functions in a patient. In various embodiments, stimulation is applied to the vagus nerve, and evoked responses are detected to verify that the stimulation captures the vagus nerve and to adjust one or more stimulation parameters that control the stimulation intensity.
摘要翻译： 神经刺激系统提供捕获验证和刺激强度调节，以确保迷走神经刺激在调节患者体内的一个或多个目标功能方面的有效性。 在各种实施例中，对迷走神经施加刺激，并且检测诱发反应以验证刺激捕获迷走神经并调节控制刺激强度的一个或多个刺激参数。
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