公开(公告)号：US09907812B2

公开(公告)日：2018-03-06

申请号：US14128281

申请日：2012-06-22

申请人： Abhijit S. Bapat ,  Gauthami Mahesh ,  Rajesh S. Gokhale ,  Sayali S. Shah ,  Shiladitya Sengupta ,  Sudhanand Prasad ,  Sumana Ghosh ,  Suresh R. Chawrai ,  Nidhi Arora ,  D. Sreedhar Reddy ,  Mallika Mishra ,  Kirti Bajaj

发明人： Abhijit S. Bapat ,  Gauthami Mahesh ,  Rajesh S. Gokhale ,  Sayali S. Shah ,  Shiladitya Sengupta ,  Sudhanand Prasad ,  Sumana Ghosh ,  Suresh R. Chawrai ,  Nidhi Arora ,  D. Sreedhar Reddy ,  Mallika Mishra ,  Kirti Bajaj

IPC分类号： A61K31/7056 ,  A61K47/48 ,  A61K31/085 ,  A61K31/496 ,  A61K8/37 ,  A61Q17/00 ,  A61K8/34 ,  A61K8/36 ,  A61K8/362 ,  A61K8/368 ,  A61K8/39 ,  A61K8/49 ,  A61Q5/00 ,  A61K8/60 ,  A61K8/81 ,  A61K8/02 ,  A01N37/46 ,  A61K47/60 ,  A61K47/54 ,  A61K47/55

CPC分类号： A61K31/7056 ,  A01N37/46 ,  A61K8/0241 ,  A61K8/347 ,  A61K8/361 ,  A61K8/362 ,  A61K8/368 ,  A61K8/37 ,  A61K8/375 ,  A61K8/39 ,  A61K8/49 ,  A61K8/4933 ,  A61K8/602 ,  A61K8/8129 ,  A61K31/085 ,  A61K31/496 ,  A61K47/54 ,  A61K47/542 ,  A61K47/552 ,  A61K47/60 ,  A61K2800/412 ,  A61K2800/413 ,  A61K2800/57 ,  A61Q5/006 ,  A61Q17/005

摘要： The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one anti-fungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA)m-X-(L)n; (ii) [(AFA)m′-X]p-L; (iii) AFA-[X-(L)n′]q; or (iv) (AFA)m″-X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m′ is 1 to 10; p is 1 to 10; n′ is 1 to 10; and q is 1 to 10, provided that q′ and n are not both 1; and m″ is 1 to 10. The invention also provides nanoparticles comprising the conjugate-based prodrugs. Additionally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles.