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1.发明申请METHOD AND USE OF MICROARRAY TECHNOLOGY AND PROTEOGENOMIC ANALYSIS TO PREDICT EFFICACY OF HUMAN AND XENOGRAPHIC CELL, TISSUE AND ORGAN TRANSPLANT 审中-公开微阵列技术和预测分析方法和应用对人类和XENOGRAPHIC细胞，组织和器官移植物的预测效果公开(公告)号：US20090149335A1
公开(公告)日：2009-06-11
申请号：US12147884
申请日：2008-06-27
申请人： Aby J. Mathew , Robert Van Buskirk , John G. Baust , John M. Baust , Dominic Clarke , Ian Nicoud
发明人： Aby J. Mathew , Robert Van Buskirk , John G. Baust , John M. Baust , Dominic Clarke , Ian Nicoud
CPC分类号： C40B30/04 , G01N33/5005 , G16B25/00
摘要： The present invention is directed to systems and proteogenomic methods for predicting the success of the transplant of a cell, tissue, or organ by providing a means to determine the quality of the cell, tissue, or organ to be transplanted. In one embodiment, the present invention uses samples from the preservation solution to obtain phenomic fingerprints correlated with transplant pre-operative and post-operative data as a pre-operative tissue diagnostic and procedural success predictive indicator.
摘要翻译： 本发明涉及用于通过提供确定要移植的细胞，组织或器官的质量的手段来预测细胞，组织或器官的移植成功的系统和蛋白质组学方法。 在一个实施方案中，本发明使用来自保存溶液的样品来获得与移植术前和术后数据相关的指纹图像，作为手术前组织诊断和程序成功预测指标。
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2.发明申请METHOD AND USE OF MICROARRAY TECHNOLOGY AND PROTEOGENOMIC ANALYSIS TO PREDICT EFFICACY OF HUMAN AND XENOGRAPHIC CELL, TISSUE AND ORGAN TRANSPLANT 审中-公开微阵列技术和预测分析方法和应用对人类和XENOGRAPHIC细胞，组织和器官移植物的预测效果公开(公告)号：US20100305000A1
公开(公告)日：2010-12-02
申请号：US12855805
申请日：2010-08-13
申请人： Aby J. Mathew , Robert Van Buskirk , John G. Baust , John M. Baust , Dominic M. Clarke , Ian B. Nicoud
发明人： Aby J. Mathew , Robert Van Buskirk , John G. Baust , John M. Baust , Dominic M. Clarke , Ian B. Nicoud
CPC分类号： C40B30/04 , G01N33/5005 , G16B25/00
摘要： The present invention is directed to systems and proteogenomic methods for predicting the success of the transplant of a cell, tissue, or organ by providing a means to determine the quality of the cell, tissue, or organ to be transplanted. In one embodiment, the present invention uses samples from the preservation solution to obtain phenomic fingerprints correlated with transplant pre-operative and post-operative data as a pre-operative tissue diagnostic and procedural success predictive indicator.
摘要翻译： 本发明涉及用于通过提供确定要移植的细胞，组织或器官的质量的手段来预测细胞，组织或器官的移植成功的系统和蛋白质组学方法。 在一个实施方案中，本发明使用来自保存溶液的样品来获得与移植术前和术后数据相关的指纹图像，作为手术前组织诊断和程序成功预测指标。
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3.发明授权Methods and compositions for the preservation of cells, tissues or organs in the vitreous state 有权用于保存玻璃状态的细胞，组织或器官的方法和组合物公开(公告)号：US06921633B2
公开(公告)日：2005-07-26
申请号：US10298497
申请日：2002-11-18
申请人： John M. Baust , John G. Baust , Robert VanBuskirk , Aby J. Mathew
发明人： John M. Baust , John G. Baust , Robert VanBuskirk , Aby J. Mathew
CPC分类号： A01N1/0221 , A01N1/02
摘要： The invention provides methods for the hypothermic preservation of cells, tissues and organs. In particular, the invention provides methods for the hypothermic preservation or storage of cells, tissues or organs in the vitreous state.
摘要翻译： 本发明提供了细胞，组织和器官的低温保存方法。 特别地，本发明提供了在玻璃体状态下细胞，组织或器官的低温保存或储存的方法。
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公开(公告)号：US20120040450A1
公开(公告)日：2012-02-16
申请号：US13265959
申请日：2010-04-29
申请人： Dominic M. Clarke , Ian B. Nicoud , Aby J. Mathew , Michael Rice
发明人： Dominic M. Clarke , Ian B. Nicoud , Aby J. Mathew , Michael Rice
IPC分类号： C12M1/00
CPC分类号： A01N1/0242 , A01N1/0268 , B01L3/50851 , B01L2300/042 , B01L2300/046 , B01L2300/1894
摘要： Provided are apparatuses for cryopreserving cells which include a vessel comprising a biocompatible substrate, wherein the vessel further comprises an interior and an exterior, and a mechanical ice nucleating device disposed in or on the vessel interior for initiating ice crystal formation. Also provided are kits comprising one or more apparatuses for cryopreserving cells and a biopreservation medium. Further provided are compositions comprising a vessel for holding cells, a mechanical ice nucleating device, a biopreservation medium, and cells disposed in the vessel. The apparatuses, kits, and compositions of the invention can optionally include an insulating material which is disposed on all or a portion of the vessel.
摘要翻译： 提供了用于冷冻保存细胞的装置，其包括包含生物相容性底物的容器，其中容器还包括内部和外部，以及设置在容器内部中或其上的用于引发冰晶形成的机械冰成核装置。 还提供了包含用于冷冻保存细胞的一个或多个装置和生物保存培养基的试剂盒。 还提供了包含用于保持细胞的容器，机械冰成核装置，生物保存介质和设置在容器中的细胞的组合物。 本发明的装置，试剂盒和组合物可任选地包括设置在容器的全部或一部分上的绝缘材料。
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公开(公告)号：US08642255B2
公开(公告)日：2014-02-04
申请号：US12934644
申请日：2009-03-27
申请人： Ian B. Nicoud , Dominic M. Clarke , Aby J. Mathew , Michael Rice
发明人： Ian B. Nicoud , Dominic M. Clarke , Aby J. Mathew , Michael Rice
IPC分类号： A01N1/02
CPC分类号： C12N5/0641 , A01N1/02 , A01N1/0226 , A01N1/0284 , A61K35/44 , A61K35/50
摘要： The present invention relates to materials and methods for hypothermic collection of whole blood, and components thereof, which can extend the holding time of blood beyond the current useable limit. Additionally, blood can be drawn directly into a hypothermic preservation solution without the addition of standard anticoagulants. This is enabled by providing sustained cellular viability under hypothermic conditions using a nutrient matrix devoid of animal proteins and containing energy substrates, free-radical scavengers, and impermeants that is ionically balanced for storage of biologic materials at low temperatures to prevent cellular stress-induced apoptosis.
摘要翻译： 本发明涉及全血及其组分的低体温收集的材料和方法，其可以将血液的保持时间延长超过目前的可用极限。 此外，血液可以直接吸入低温保存溶液中，而不添加标准抗凝剂。 这是通过在低温条件下使用不含动物蛋白质的营养基质并含有能量底物，自由基清除剂和离子平衡的不渗液在低温下储存生物材料以防止细胞应激诱导的细胞凋亡来实现的 。
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6.发明授权公开(公告)号：US09125397B2
公开(公告)日：2015-09-08
申请号：US13265959
申请日：2010-04-29
申请人： Dominic M. Clarke , Ian B. Nicoud , Aby J. Mathew , Michael Rice
发明人： Dominic M. Clarke , Ian B. Nicoud , Aby J. Mathew , Michael Rice
CPC分类号： A01N1/0242 , A01N1/0268 , B01L3/50851 , B01L2300/042 , B01L2300/046 , B01L2300/1894
摘要： Provided are apparatuses for cryopreserving cells which include a vessel comprising a biocompatible substrate, wherein the vessel further comprises an interior and an exterior, and a mechanical ice nucleating device disposed in or on the vessel interior for initiating ice crystal formation. Also provided are kits comprising one or more apparatuses for cryopreserving cells and a biopreservation medium. Further provided are compositions comprising a vessel for holding cells, a mechanical ice nucleating device, a biopreservation medium, and cells disposed in the vessel. The apparatuses, kits, and compositions of the invention can optionally include an insulating material which is disposed on all or a portion of the vessel.
摘要翻译： 提供了用于冷冻保存细胞的装置，其包括包含生物相容性底物的容器，其中容器还包括内部和外部，以及设置在容器内部中或其上的用于引发冰晶形成的机械冰成核装置。 还提供了包含用于冷冻保存细胞的一个或多个装置和生物保存培养基的试剂盒。 还提供了包含用于保持细胞的容器，机械冰成核装置，生物保存介质和设置在容器中的细胞的组合物。 本发明的装置，试剂盒和组合物可任选地包括设置在容器的全部或一部分上的绝缘材料。
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公开(公告)号：US20110152719A1
公开(公告)日：2011-06-23
申请号：US12934644
申请日：2009-03-27
申请人： Ian B. Nicoud , Dominic M. Clarke , Aby J. Mathew , Michael Rice
发明人： Ian B. Nicoud , Dominic M. Clarke , Aby J. Mathew , Michael Rice
CPC分类号： C12N5/0641 , A01N1/02 , A01N1/0226 , A01N1/0284 , A61K35/44 , A61K35/50
摘要： The present invention relates to materials and methods for hypothermic collection of whole blood, and components thereof, which can extend the holding time of blood beyond the current useable limit. Additionally, blood can be drawn directly into a hypothermic preservation solution without the addition of standard anticoagulants. This is enabled by providing sustained cellular viability under hypothermic conditions using a nutrient matrix devoid of animal proteins and containing energy substrates, free-radical scavengers, and impermeants that is ionically balanced for storage of biologic materials at low temperatures to prevent cellular stress-induced apoptosis.
摘要翻译： 本发明涉及全血及其组分的低体温收集的材料和方法，其可以将血液的保持时间延长超过目前的可用极限。 此外，血液可以直接吸入低温保存溶液中，而不添加标准抗凝剂。 这是通过在低温条件下使用不含动物蛋白质的营养基质并含有能量底物，自由基清除剂和离子平衡的不渗液在低温下储存生物材料以防止细胞应激诱导的细胞凋亡来实现的 。
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