公开(公告)号：US20220267478A1

公开(公告)日：2022-08-25

申请号：US17631698

申请日：2020-07-29

Applicant: Academia Sinica

Inventor： Che-ming Jack Hu ,  Chien-wei Lin ,  Jung-chen Lin ,  Chen-hsueh Pai

IPC: C07K17/08 ,  A61K47/62 ,  A61K47/69 ,  C07K17/04 ,  A61P31/16 ,  A61P35/00

Abstract: A carrier system that includes a nanocarrier and a peptide non-covalently associated with the nanocarrier. The peptide contains an adaptor peptide sequence fused to the N-terminus of a target peptide, the adaptor peptide sequence being designed to facilitate the association to the nanocarrier. Also disclosed is a method for improving the immunogenicity of a peptide antigen by fusing it to an adaptor peptide sequence to form an immunizing peptide and contacting the immunizing peptide with a compatible nanocarrier. Further, a method is provided for treating a condition by immunization with a target peptide that has been fused to an adaptor peptide sequence and thereby associated with a nanocarrier. The method induces an immune response against the target peptide for treating cancer, viral infection, bacterial infection, parasitic infection, autoimmunity, or undesired immune responses to a biologies treatment.