公开(公告)号：US20150202316A1

公开(公告)日：2015-07-23

申请号：US14599291

申请日：2015-01-16

Applicant: Academia Sinica

Inventor： Han-Chung WU ,  Yi-Hsuan CHI

IPC: A61K47/48 ,  G01N33/574 ,  A61K31/704

CPC classification number: A61K47/48246 ,  A61K31/704 ,  A61K47/48815 ,  A61K47/64 ,  A61K47/6911 ,  G01N33/57423 ,  G01N2458/00

Abstract: A conjugate is disclosed. The conjugate comprises (a) an isolated or a synthetic targeting peptide of less than 15 amino acid residues in length, comprising an amino acid sequence having at least 90% identity to a sequence selected from the group consisting of SEQ ID NOs: 1-8; and (b) a component conjugated to the targeting peptide, the component being selected from the group consisting of a drug delivery vehicle, an anti-cancer drug, a micelle, a nanoparticle, a liposome, a polymer, a lipid, an oligonucleotide, a peptide, a polypeptide, a protein, a cell, an imaging agent, and a labeling agent. Methods of treating lung cancer and detecting lung cancer cells are also disclosed.

Abstract translation: 公开了缀合物。 缀合物包含（a）长度小于15个氨基酸残基的分离或合成的靶向肽，其包含与选自SEQ ID NO：1-8的序列具有至少90％同一性的氨基酸序列 ; 和（b）与靶向肽缀合的组分，该组分选自药物递送载体，抗癌药物，胶束，纳米颗粒，脂质体，聚合物，脂质，寡核苷酸， 肽，多肽，蛋白质，细胞，成像剂和标记试剂。 还公开了治疗肺癌和检测肺癌细胞的方法。