公开(公告)号：US11813317B2

公开(公告)日：2023-11-14

申请号：US17540289

申请日：2021-12-02

申请人： Academia Sinica ,  National Yang Ming Chiao Tung University

发明人： Ruey-Hwa Chen ,  Yu-Hsuan Chen ,  Tzu-Yu Huang ,  Wen-Hsin Li ,  Ting-Fen Tsai ,  Zhao-Qing Shen

IPC分类号： A61P3/00 ,  C12N15/86 ,  A61K38/48 ,  A61P3/04 ,  A61K45/06 ,  C12N9/48

CPC分类号： A61K38/4813 ,  A61K45/06 ,  A61P3/04 ,  C12N9/485 ,  C12N15/86 ,  C12Y304/19012 ,  C12N2750/14111

摘要： Provided is a method for preventing or treating a metabolic disorder, including administering to a subject a therapeutically effective amount of TRABID protein or a functionally related variant thereof, or a nucleic acid encoding TRABID protein or a functionally related variant thereof. Also provided is a method for reducing fat accumulation through TRABID-induced deubiquitination to promote autophagy activity and lipid metabolism.

公开(公告)号：US20220175895A1

公开(公告)日：2022-06-09

申请号：US17540289

申请日：2021-12-02

申请人： Academia Sinica ,  National Yang Ming Chiao Tung University

发明人： Ruey-Hwa Chen ,  Yu-Hsuan Chen ,  Tzu-Yu Huang ,  Wen-Hsin Li ,  Ting-Fen Tsai ,  Zhao-Qing Shen

IPC分类号： A61K38/48 ,  C12N15/86 ,  C12N9/48 ,  A61P3/04 ,  A61K45/06

摘要： Provided is a method for preventing or treating a metabolic disorder, including administering to a subject a therapeutically effective amount of TRABID protein or a functionally related variant thereof, or a nucleic acid encoding TRABID protein or a functionally related variant thereof. Also provided is a method for reducing fat accumulation through TRABID-induced deubiquitination to promote autophagy activity and lipid metabolism.