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公开(公告)号：US11813317B2
公开(公告)日：2023-11-14
申请号：US17540289
申请日：2021-12-02
发明人： Ruey-Hwa Chen , Yu-Hsuan Chen , Tzu-Yu Huang , Wen-Hsin Li , Ting-Fen Tsai , Zhao-Qing Shen
CPC分类号： A61K38/4813 , A61K45/06 , A61P3/04 , C12N9/485 , C12N15/86 , C12Y304/19012 , C12N2750/14111
摘要： Provided is a method for preventing or treating a metabolic disorder, including administering to a subject a therapeutically effective amount of TRABID protein or a functionally related variant thereof, or a nucleic acid encoding TRABID protein or a functionally related variant thereof. Also provided is a method for reducing fat accumulation through TRABID-induced deubiquitination to promote autophagy activity and lipid metabolism.
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公开(公告)号：US20220175895A1
公开(公告)日：2022-06-09
申请号：US17540289
申请日：2021-12-02
发明人： Ruey-Hwa Chen , Yu-Hsuan Chen , Tzu-Yu Huang , Wen-Hsin Li , Ting-Fen Tsai , Zhao-Qing Shen
摘要： Provided is a method for preventing or treating a metabolic disorder, including administering to a subject a therapeutically effective amount of TRABID protein or a functionally related variant thereof, or a nucleic acid encoding TRABID protein or a functionally related variant thereof. Also provided is a method for reducing fat accumulation through TRABID-induced deubiquitination to promote autophagy activity and lipid metabolism.
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公开(公告)号：US11827629B2
公开(公告)日：2023-11-28
申请号：US17824547
申请日：2022-05-25
发明人： Ting-Fen Tsai , Jinq-Chyi Lee , Teng-Kuang Yeh
IPC分类号： C07D209/44 , C07D417/12 , A61P1/16 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D495/04
CPC分类号： C07D417/12 , A61P1/16 , C07D209/44 , C07D401/12 , C07D403/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D495/04
摘要： Isoindoline compounds and their pharmaceutical compositions. Also provided are methods of treating a Cisd2-insufficiency associated disorder and protecting against doxorubicin-induced cardiotoxicity.
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公开(公告)号：US20230100367A1
公开(公告)日：2023-03-30
申请号：US17894333
申请日：2022-08-24
申请人： National Yang Ming Chiao Tung University , National Health Research Institutes , Chang Gung Medical Foundation, Chang Gung Memorial Hospital, Linkou
发明人： Ting-Fen Tsai , Jinq-Chyi Lee , Hui-Yi Shiao , Chi-Hsiao Yeh
IPC分类号： C07D333/36 , C07D417/12 , A61P9/00
摘要： A method of treating a Cisd2 insufficiency-associated disorder. The method includes administering to a subject in need a compound of formula (I). Also disclosed is a method of increasing Cisd2 gene expression.
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公开(公告)号：US20220411418A1
公开(公告)日：2022-12-29
申请号：US17824547
申请日：2022-05-25
发明人： Ting-Fen Tsai , Jinq-Chyi Lee , Teng-Kuang Yeh
IPC分类号： C07D417/12 , C07D401/12 , C07D209/44 , C07D495/04 , C07D403/12 , C07D413/12 , C07D409/12 , C07D413/14 , A61P1/16
摘要： Isoindoline compounds and their pharmaceutical compositions. Also provided are methods of treating a Cisd2-insufficiency associated disorder and protecting against doxorubicin-induced cardiotoxicity.
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