公开(公告)号：US20220396563A1

公开(公告)日：2022-12-15

申请号：US17366670

申请日：2021-07-02

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan WILES ,  Avinash S. PHADKE ,  Milind DESHPANDE ,  Atul AGARWAL ,  Dawei CHEN ,  Venkat Rao GADHACHANDA ,  Akihiro HASHIMOTO ,  Godwin PAIS ,  Qiuping WANG ,  Xiangzhu WANG ,  Joel Charles BARRISH ,  William GREENLEE ,  Kyle J. EASTMAN

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D471/04 ,  C07D471/08 ,  C07D491/107 ,  C07D498/10 ,  C07F5/02

摘要： Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

公开(公告)号：US20220315562A1

公开(公告)日：2022-10-06

申请号：US17835098

申请日：2022-06-08

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan WILES ,  Avinash S. PHADKE ,  Milind DESHPANDE ,  Atul AGARWAL ,  Dawei CHEN ,  Venkat Rao GADHACHANDA ,  Akihiro HASHIMOTO ,  Godwin PAIS ,  Qiuping WANG ,  Xiangzhu WANG ,  William GREENLEE

IPC分类号： C07D403/04 ,  C07D401/14 ,  C07D403/14 ,  C07D471/04 ,  C07D413/14 ,  C07F9/6558 ,  C07D417/14 ,  C07D487/04 ,  C07D519/00 ,  C07D403/12 ,  C07D407/14 ,  C07D409/14 ,  C07D403/10 ,  C07D513/04 ,  C07D487/22 ,  A61P37/00 ,  A61P1/16 ,  A61P29/00 ,  C07D405/14 ,  C07D493/04

摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I′″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

公开(公告)号：US20230287005A1

公开(公告)日：2023-09-14

申请号：US18124427

申请日：2023-03-21

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan WILES ,  Avinash S. PHADKE ,  Milind DESHPANDE ,  Atul AGARWAL ,  Dawei CHEN ,  Venkat Rao GADHACHANDA ,  Akihiro HASHIMOTO ,  Godwin PAIS ,  Qiuping WANG ,  Xiangzhu WANG

IPC分类号： C07D513/04 ,  C07D403/14 ,  C07D401/14 ,  C07D471/04 ,  C07D417/14 ,  C07D413/14 ,  C07D487/04 ,  C07D405/14 ,  C07D409/14 ,  C07D495/04 ,  C07D493/04 ,  C07D403/06

CPC分类号： C07D513/04 ,  C07D403/14 ,  C07D401/14 ,  C07D471/04 ,  C07D417/14 ,  C07D413/14 ,  C07D487/04 ,  C07D405/14 ,  C07D409/14 ,  C07D495/04 ,  C07D493/04 ,  C07D403/06

摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.

公开(公告)号：US20210269458A1

公开(公告)日：2021-09-02

申请号：US17015171

申请日：2020-09-09

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan WILES ,  Avinash S. PHADKE ,  Milind DESHPANDE ,  Atul AGARWAL ,  Dawei CHEN ,  Venkat Rao GADHACHANDA ,  Akihiro HASHIMOTO ,  Godwin PAIS ,  Qiuping WANG ,  Xiangzhu WANG

IPC分类号： C07D513/04 ,  C07D403/14 ,  C07D401/14 ,  C07D471/04 ,  C07D417/14 ,  C07D413/14 ,  C07D487/04 ,  C07D405/14 ,  C07D409/14 ,  C07D495/04 ,  C07D493/04 ,  C07D403/06

摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.

公开(公告)号：US20230357199A1

公开(公告)日：2023-11-09

申请号：US18196128

申请日：2023-05-11

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan WILES ,  Avinash S. PHADKE ,  Milind DESHPANDE ,  Atul AGARWAL ,  Dawei CHEN ,  Venkat Rao GADHACHANDA ,  Akihiro HASHIMOTO ,  Godwin PAIS ,  Qiuping WANG ,  Xiangzhu WANG ,  Joel Charles BARRISH ,  William GREENLEE ,  Kyle J. EASTMAN

IPC分类号： C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D471/04 ,  C07D471/08 ,  C07D491/107 ,  C07D498/10 ,  C07F5/02

CPC分类号： C07D401/14 ,  C07D403/14 ,  C07D409/14 ,  C07D471/04 ,  C07D471/08 ,  C07D491/107 ,  C07D498/10 ,  C07F5/027

摘要： Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

公开(公告)号：US20230071620A1

公开(公告)日：2023-03-09

申请号：US17872104

申请日：2022-07-25

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan WILES ,  Avinash S. PHADKE ,  Milind DESHPANDE ,  Atul AGARWAL ,  Dawei CHEN ,  Venkat Rao GADHACHANDA ,  Akihiro HASHIMOTO ,  Godwin PAIS ,  Qiuping WANG ,  Xiangzhu WANG ,  Joel Charles BARRISH ,  William GREENLEE ,  Kyle J. EASTMAN

IPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/10 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14 ,  C07D471/04 ,  C07D493/04 ,  C07D495/04 ,  C07D513/04 ,  C07F9/6558

摘要： Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

公开(公告)号：US20210122733A1

公开(公告)日：2021-04-29

申请号：US17135184

申请日：2020-12-28

申请人： Achillion Pharmaceuticals, Inc.

发明人： Jason Allan WILES ,  Avinash S. PHADKE ,  Milind DESHPANDE ,  Atul AGARWAL ,  Dawei CHEN ,  Venkat Rao GADHACHANDA ,  Akihiro HASHIMOTO ,  Godwin PAIS ,  Qiuping WANG ,  Xiangzhu WANG ,  William GREENLEE

IPC分类号： C07D401/14 ,  C07D495/04 ,  A61K45/06 ,  C07D487/04 ,  C07D209/12 ,  C07D519/00 ,  C07D403/14 ,  C07D513/04 ,  C07D405/14 ,  C07D403/12 ,  C07D401/12

摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I′″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.