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公开(公告)号：US20210300934A1
公开(公告)日：2021-09-30
申请号：US17314155
申请日：2021-05-07
发明人： Jason Allan WILES , Avinash S. PHADKE , Dawei CHEN , Venkat Rao GADHACHANDA , Joel Charles BARRISH , Atul AGARWAL , Kyle J. EASTMAN
IPC分类号： C07D487/08 , C07D498/08 , C07D513/08 , C07D487/18
摘要： Macrocyclic Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, and Formula VIII or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
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2.发明申请公开(公告)号：US20220396563A1
公开(公告)日：2022-12-15
申请号：US17366670
申请日：2021-07-02
发明人： Jason Allan WILES , Avinash S. PHADKE , Milind DESHPANDE , Atul AGARWAL , Dawei CHEN , Venkat Rao GADHACHANDA , Akihiro HASHIMOTO , Godwin PAIS , Qiuping WANG , Xiangzhu WANG , Joel Charles BARRISH , William GREENLEE , Kyle J. EASTMAN
IPC分类号： C07D401/14 , C07D403/14 , C07D409/14 , C07D471/04 , C07D471/08 , C07D491/107 , C07D498/10 , C07F5/02
摘要： Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
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3.发明申请公开(公告)号：US20220315562A1
公开(公告)日：2022-10-06
申请号：US17835098
申请日：2022-06-08
发明人： Jason Allan WILES , Avinash S. PHADKE , Milind DESHPANDE , Atul AGARWAL , Dawei CHEN , Venkat Rao GADHACHANDA , Akihiro HASHIMOTO , Godwin PAIS , Qiuping WANG , Xiangzhu WANG , William GREENLEE
IPC分类号： C07D403/04 , C07D401/14 , C07D403/14 , C07D471/04 , C07D413/14 , C07F9/6558 , C07D417/14 , C07D487/04 , C07D519/00 , C07D403/12 , C07D407/14 , C07D409/14 , C07D403/10 , C07D513/04 , C07D487/22 , A61P37/00 , A61P1/16 , A61P29/00 , C07D405/14 , C07D493/04
摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I′″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.
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公开(公告)号：US20230287005A1
公开(公告)日：2023-09-14
申请号：US18124427
申请日：2023-03-21
发明人： Jason Allan WILES , Avinash S. PHADKE , Milind DESHPANDE , Atul AGARWAL , Dawei CHEN , Venkat Rao GADHACHANDA , Akihiro HASHIMOTO , Godwin PAIS , Qiuping WANG , Xiangzhu WANG
IPC分类号： C07D513/04 , C07D403/14 , C07D401/14 , C07D471/04 , C07D417/14 , C07D413/14 , C07D487/04 , C07D405/14 , C07D409/14 , C07D495/04 , C07D493/04 , C07D403/06
CPC分类号： C07D513/04 , C07D403/14 , C07D401/14 , C07D471/04 , C07D417/14 , C07D413/14 , C07D487/04 , C07D405/14 , C07D409/14 , C07D495/04 , C07D493/04 , C07D403/06
摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.
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公开(公告)号：US20210269458A1
公开(公告)日：2021-09-02
申请号：US17015171
申请日：2020-09-09
发明人： Jason Allan WILES , Avinash S. PHADKE , Milind DESHPANDE , Atul AGARWAL , Dawei CHEN , Venkat Rao GADHACHANDA , Akihiro HASHIMOTO , Godwin PAIS , Qiuping WANG , Xiangzhu WANG
IPC分类号： C07D513/04 , C07D403/14 , C07D401/14 , C07D471/04 , C07D417/14 , C07D413/14 , C07D487/04 , C07D405/14 , C07D409/14 , C07D495/04 , C07D493/04 , C07D403/06
摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D comprising Formula I, or a pharmaceutically acceptable salt or composition thereof wherein R12 or R13 on the A group is an aryl, heteroaryl or heterocycle (R32) are provided. The inhibitors of Factor D described herein reduce the excessive activation of complement.
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公开(公告)号：US20240059702A1
公开(公告)日：2024-02-22
申请号：US18196002
申请日：2023-05-11
发明人： Jason Allan WILES , Avinash S. PHADKE , Dawei CHEN , Venkat Rao GADHACHANDA , Joel Charles BARRISH , Atul AGARWAL , Kyle J. EASTMAN
IPC分类号： C07D487/08 , C07D498/08 , C07D513/08 , C07D487/18 , A61P7/00 , A61P31/12 , A61P7/02
CPC分类号： C07D487/08 , C07D498/08 , C07D513/08 , A61P7/02 , A61P7/00 , A61P31/12 , C07D487/18
摘要： Macrocyclic Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, and Formula VIII or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
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7.发明公开公开(公告)号：US20230357199A1
公开(公告)日：2023-11-09
申请号：US18196128
申请日：2023-05-11
发明人： Jason Allan WILES , Avinash S. PHADKE , Milind DESHPANDE , Atul AGARWAL , Dawei CHEN , Venkat Rao GADHACHANDA , Akihiro HASHIMOTO , Godwin PAIS , Qiuping WANG , Xiangzhu WANG , Joel Charles BARRISH , William GREENLEE , Kyle J. EASTMAN
IPC分类号： C07D401/14 , C07D403/14 , C07D409/14 , C07D471/04 , C07D471/08 , C07D491/107 , C07D498/10 , C07F5/02
CPC分类号： C07D401/14 , C07D403/14 , C07D409/14 , C07D471/04 , C07D471/08 , C07D491/107 , C07D498/10 , C07F5/027
摘要： Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
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公开(公告)号：US20230071620A1
公开(公告)日：2023-03-09
申请号：US17872104
申请日：2022-07-25
发明人： Jason Allan WILES , Avinash S. PHADKE , Milind DESHPANDE , Atul AGARWAL , Dawei CHEN , Venkat Rao GADHACHANDA , Akihiro HASHIMOTO , Godwin PAIS , Qiuping WANG , Xiangzhu WANG , Joel Charles BARRISH , William GREENLEE , Kyle J. EASTMAN
IPC分类号： C07D401/14 , C07D403/06 , C07D403/10 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D493/04 , C07D495/04 , C07D513/04 , C07F9/6558
摘要： Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, and Formula IV or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.
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公开(公告)号：US20220119400A1
公开(公告)日：2022-04-21
申请号：US17564446
申请日：2021-12-29
发明人： Jason Allan WILES , Avinash PHADKE
IPC分类号： C07D491/056 , C07D401/14 , C07D401/04 , C07D401/06 , C07D239/94 , C07D417/12 , A61K31/454 , A61K45/06 , C07D403/12 , C07D487/08 , A61K31/662 , C07F9/38 , C07D403/04 , A61K31/517 , C07D403/14 , C07D417/14 , C07D451/02 , C07D471/02
摘要： Compounds, methods of use, and processes for making inhibitors of Complement Factor B are provided.
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公开(公告)号：US20210122733A1
公开(公告)日：2021-04-29
申请号：US17135184
申请日：2020-12-28
发明人： Jason Allan WILES , Avinash S. PHADKE , Milind DESHPANDE , Atul AGARWAL , Dawei CHEN , Venkat Rao GADHACHANDA , Akihiro HASHIMOTO , Godwin PAIS , Qiuping WANG , Xiangzhu WANG , William GREENLEE
IPC分类号： C07D401/14 , C07D495/04 , A61K45/06 , C07D487/04 , C07D209/12 , C07D519/00 , C07D403/14 , C07D513/04 , C07D405/14 , C07D403/12 , C07D401/12
摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I′″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.
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