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1.发明申请Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors 失效杂环氧基取代的苯基氨基嘧啶作为rho激酶抑制剂公开(公告)号：US20060241127A1
公开(公告)日：2006-10-26
申请号：US10531889
申请日：2003-10-16
申请人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Perez , Heimo Ehmke
发明人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Gnoth , Klaus Munter , Dieter Lang , Santiago Perez , Heimo Ehmke
IPC分类号： A61K31/519 , A61K31/513 , A61K31/506 , C07D487/04 , C07D403/02
CPC分类号： C07D401/14 , C07D403/12 , C07D471/04
摘要： The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-Kinase.
摘要翻译： 本发明涉及杂芳氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物。 本发明化合物抑制Rho-激酶。
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2.发明申请Pyrrolopyridine-Substituted Benzol Derivatives for Treating Cardiovascular Diseases 审中-公开用于治疗心血管疾病的吡咯并吡啶取代的苯衍生物公开(公告)号：US20080249105A1
公开(公告)日：2008-10-09
申请号：US10582184
申请日：2004-11-26
申请人： Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Minter , Dieter Lang , Santiago Figueroa Perez , Marcus Bauser , Achim Feurer , Heimo Ehmke
发明人： Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Mark Jean Gnoth , Klaus Minter , Dieter Lang , Santiago Figueroa Perez , Marcus Bauser , Achim Feurer , Heimo Ehmke
IPC分类号： A61K31/496 , C07D471/02 , A61K31/437 , A61P15/10 , A61P9/00 , C07D401/14
CPC分类号： C07D471/04
摘要： The invention relates to heteroaryl-substituted benzenes, to a process for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases in humans and animals, in particular cardiovascular disorders.
摘要翻译： 本发明涉及杂芳基取代的苯，涉及其制备方法及其用于制备用于治疗和/或预防人和动物疾病，特别是心血管疾病的药物。
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3.发明授权Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors 失效杂环氧基取代的苯基氨基嘧啶作为rho激酶抑制剂公开(公告)号：US07737153B2
公开(公告)日：2010-06-15
申请号：US10531889
申请日：2003-10-16
申请人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Mark Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Heimo Ehmke
发明人： Achim Feurer , Samir Bennabi , Heike Heckroth , Hartmut Schirok , Joachim Mittendorf , Raimund Kast , Johannes-Peter Stasch , Jean Mark Gnoth , Klaus Münter , Dieter Lang , Santiago Figueroa Perez , Heimo Ehmke
IPC分类号： A01N43/90 , A61K31/519 , A61K31/505 , C07D487/00 , C07D239/02 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D401/14 , C07D403/12 , C07D471/04
摘要： The invention relates to heteroaryloxy-substituted phenylaminopyrimidines, to methods for the production thereof, and to the use of the same for producing medicaments for the treatment and/or prophylaxis of diseases, especially cardiovascular diseases. The inventive compounds inhibit Rho-Kinase.
摘要翻译： 本发明涉及杂芳氧基取代的苯基氨基嘧啶，其制备方法及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物。 本发明化合物抑制Rho-激酶。
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公开(公告)号：US06414009B1
公开(公告)日：2002-07-02
申请号：US09648082
申请日：2000-08-25
申请人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
发明人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
IPC分类号： A61K31416
CPC分类号： C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
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公开(公告)号：US06462068B1
公开(公告)日：2002-10-08
申请号：US09644305
申请日：2000-08-23
申请人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
发明人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
IPC分类号： A61K31416
CPC分类号： C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
摘要翻译： 本发明涉及新的杂环基甲基取代的吡唑衍生物，其制备方法及其作为药物的用途，特别是用于治疗心血管疾病的药物。
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公开(公告)号：US06410740B1
公开(公告)日：2002-06-25
申请号：US09645834
申请日：2000-08-25
申请人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
发明人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
IPC分类号： C07D41304
CPC分类号： C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
摘要翻译： 本发明涉及新的杂环基甲基取代的吡唑衍生物，其制备方法及其作为药物的用途，特别是用于治疗心血管疾病的药物。
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7.发明授权Use of condensated (hetaryl-substituted) 1-benzal-3-pyrazol derivates for treating special diseases of the cardiovascular and the central nervous systems 失效使用缩合（杂芳基取代的）1-苄基-3-吡唑衍生物治疗心血管和中枢神经系统的特殊疾病公开(公告)号：US06180656B2
公开(公告)日：2001-01-30
申请号：US09284032
申请日：1999-04-06
申请人： Chantal F{umlaut over (u)}rstner , Alexander Straub , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim H{umlaut over (u)}tter , Klaus Dembowsky
发明人： Chantal F{umlaut over (u)}rstner , Alexander Straub , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim H{umlaut over (u)}tter , Klaus Dembowsky
IPC分类号： A61K31415
CPC分类号： C07D405/04 , A61K31/416
摘要： The present invention relates to the new use of 1-benzyl-3-(substituted hetaryl)-fused pyrazole derivatives, some of which are known, of the general formula (I) in which R1 to R4 have the meaning indicated in the description, as medicaments, and to new active compounds, in particular to their use as vasodilators, if appropriate in combination with organic nitrates and NO donors and if appropriate in combination with compounds which inhibit the degradation of cGMP.
摘要翻译： 本发明涉及1-苄基-3-（取代的杂芳基） - 引入的吡唑衍生物的新用途，其中一些是已知的通式（I），其中R 1至R 4具有说明书中指出的含义， 作为药物，以及新的活性化合物，特别是它们用作血管舒张剂，如果适合与有机硝酸盐和NO供体结合使用，并且适当时与抑制cGMP降解的化合物组合使用。
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8.发明授权Heterocyclylmethyl-substituted pyrazole derivatives and their use for treating cardiovascular diseases 失效杂环甲基取代的吡唑衍生物及其用于治疗心血管疾病的用途
公开(公告)号：US6166027A
公开(公告)日：2000-12-26
申请号：US284172
申请日：1999-04-09
申请人： Alexander Straub , Chantal Furstner , Ulrich Niewohner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hutter , Klaus Dembowsky , Dieter Arlt
发明人： Alexander Straub , Chantal Furstner , Ulrich Niewohner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hutter , Klaus Dembowsky , Dieter Arlt
IPC分类号： A61K31/416 , A61K31/422 , A61K31/427 , A61K31/443 , A61K31/4433 , A61K31/501 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P25/28 , C07D20060101 , C07D263/32 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04 , A61K31/506
CPC分类号： C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
摘要翻译： PCT No.PCT / EP97 / 05432 Sec。 371日期1999年4月9日第 102（e）日期1999年4月9日PCT 1997年10月2日PCT公布。 第WO98 / 16507号公报 日期：1998年4月23日本发明涉及新的杂环基甲基取代的吡唑衍生物，其制备方法及其作为药物的用途，特别是用于治疗心血管疾病的药物。
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9.发明授权Substituted pyrazole derivatives for the treatment of cardiocirculatory diseases 失效用于治疗心脏循环疾病的取代的吡唑衍生物公开(公告)号：US06451805B1
公开(公告)日：2002-09-17
申请号：US09297121
申请日：1999-04-23
申请人： Alexander Straub , Chantal Fürstner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky
发明人： Alexander Straub , Chantal Fürstner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky
IPC分类号： A61K31506
CPC分类号： C07D405/04 , C07D471/04 , C07D487/04
摘要： The present invention relates to new substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for the treatment of cardiovascular disorders.
摘要翻译： 本发明涉及新的取代的吡唑衍生物，其制备方法及其作为药物的用途，特别是用于治疗心血管疾病的药物。
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公开(公告)号：US06387940B1
公开(公告)日：2002-05-14
申请号：US09644179
申请日：2000-08-23
申请人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
发明人： Alexander Straub , Chantal Fürstner , Ulrich Niewöhner , Thomas Jaetsch , Achim Feurer , Raimund Kast , Johannes-Peter Stasch , Elisabeth Perzborn , Joachim Hütter , Klaus Dembowsky , Dieter Arlt
IPC分类号： A61K314155
CPC分类号： C07D401/04 , C07D263/32 , C07D403/04 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D417/04
摘要： The present invention relates to new heterocyclylmethyl-substituted pyrazole derivatives, processes for their preparation and their use as medicaments, in particular as medicaments for treatment of cardiovascular diseases.
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