公开(公告)号：US20170056501A1

公开(公告)日：2017-03-02

申请号：US15252760

申请日：2016-08-31

申请人： Acura Pharmaceuticals, Inc.

发明人： Robert Barnett JONES

IPC分类号： A61K47/02 ,  A61K47/12 ,  A61K31/5517

CPC分类号： A61K47/02 ,  A61K9/2027 ,  A61K31/5517 ,  A61K47/12

摘要： An abuse deterrent pharmaceutical composition including an acid soluble salt of a pharmaceutically active ingredient and a buffering ingredient; wherein the acid soluble salt of the pharmaceutically active ingredient and the buffering ingredient retard release of the pharmaceutically active ingredient when the composition is ingested in excess of an intended dosage.

摘要翻译： 包含药学活性成分的酸溶性盐和缓冲成分的滥用威慑药物组合物; 其中药物活性成分的酸可溶性盐和缓冲成分在组合物摄取超过预定剂量时阻止药物活性成分的释放。

公开(公告)号：US20210113542A1

公开(公告)日：2021-04-22

申请号：US16498746

申请日：2018-03-30

申请人： ACURA PHARMACEUTICALS, INC.

发明人： Albert W. BRZECZKO ,  Robert Barnett JONES

IPC分类号： A61K31/451 ,  A61K47/02 ,  A61K47/32 ,  A61K47/36 ,  A61K47/42 ,  A61K47/14 ,  A61K47/12 ,  A61K47/26 ,  A61K47/38 ,  A61K47/46 ,  A61K45/06 ,  A61K31/46 ,  A61K31/485 ,  A61K31/426 ,  A61K9/16

摘要： An abuse deterrent pharmaceutical composition including a drug susceptible to abuse, a first acid soluble ingredient, a first buffering ingredient, and a delayed release buffering component.

公开(公告)号：US20170112825A1

公开(公告)日：2017-04-27

申请号：US15331643

申请日：2016-10-21

申请人： Acura Pharmaceuticals, Inc.

发明人： Robert Barnett JONES

IPC分类号： A61K31/485 ,  A61K47/48 ,  A61K9/00

CPC分类号： A61K31/485 ,  A61K9/0053 ,  A61K45/06 ,  A61K47/54 ,  A61K47/542

摘要： An abuse deterrent pharmaceutical composition including an abuse deterrent pharmaceutical composition including a prodrug of a pharmaceutically active ingredient and an enzyme inhibitor, wherein the enzyme inhibitor retards conversion of the prodrug to the pharmaceutically active ingredient when the composition is ingested in excess of an intended dosage.