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1.发明申请VACCINES WITH ONCOFETAL ANTIGEN/ILRP-LOADED AUTOLOGOUS DENDRITIC CELLS AND USES THEREOF 审中-公开具有ONCOFETAL抗原/ ILRP载体的自体细胞细胞的疫苗及其用途公开(公告)号：US20130052211A1
公开(公告)日：2013-02-28
申请号：US13383103
申请日：2010-07-09
IPC分类号： A61K39/00 , G01N33/569 , C12N5/0784 , A61P37/04 , A61P35/00
CPC分类号： A61K39/0011 , A61K35/26 , A61K2039/5154 , C12N5/0639 , C12N2501/02 , C12N2501/22 , C12N2501/23 , C12N2501/25
摘要： Disclosed are compositions containing isolated monocyte-derived mature dendritic cells loaded with OFA/iLRP, or a fragment thereof that selectively stimulates T cytotoxic lymphocytes, and a carrier, vaccine compositions containing effective dosage amounts of the dendritic cells, methods of making the vaccines, and methods of cancer treatment or therapy that entail administration of the vaccines to cancer patients.
摘要翻译： 公开了含有分离的单核细胞衍生的成熟树突状细胞的装配有选择性刺激T细胞毒性淋巴细胞的OFA / iLRP或其片段的载体，含有有效剂量的树突细胞的载体，疫苗组合物，制备疫苗的方法和 癌症治疗或治疗方法需要将疫苗给予癌症患者。
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2.发明授权Oncofetal antigen specific t-lymphocyte mediated immune response: manipulation and uses of oncofetal antigen specific CD4, CD8 cytotoxic and suppressor T cells and interleukin-10 失效Oncofetal抗原特异性T淋巴细胞介导的免疫应答：癌症抗原特异性CD4，CD8细胞毒性和抑制T细胞和白细胞介素-10的操作和用途公开(公告)号：US06335174B1
公开(公告)日：2002-01-01
申请号：US08835069
申请日：1997-04-04
IPC分类号： G01N35574
CPC分类号： G01N33/57476 , C07K16/244 , Y10S435/975
摘要： The present invention provides a method of determining the success of a cancer therapy in an individual, comprising the step of measuring the frequency of occurence of an oncofetal antigen-specific subclasses in the individual's peripheral blood. Also provided is a method of determining whether protective immunity against a tumor will develop in an individual, comprising the step of measuring the frequency of oncofetal antigen-specific T cells, tumor cells and macrophages at the site of the tumor which secrete IL-10. Additionally, a method of determining whether an individual having a tumor will go into remission or remain in remission, comprising the step of measuring the frequency of oncofetal antigen-specific Th1 cells, Tc cells and Ts cells, IL-10 and interferon-&ggr; secreting T cells in the peripheral blood.
摘要翻译： 本发明提供了确定个体癌症治疗成功的方法，包括测量个体外周血中癌胚抗原特异性亚类的发生频率的步骤。 还提供了确定个体中是否会发展针对肿瘤的保护性免疫的方法，包括测量在分泌IL-10的肿瘤部位的癌胚抗原特异性T细胞，肿瘤细胞和巨噬细胞的频率的步骤。 此外，确定具有肿瘤的个体是否将进入缓解或保持缓解的方法，包括测量癌胚抗原特异性Th1细胞，Tc细胞和Ts细胞，IL-10和干扰素-γ分泌的频率的步骤 外周血T细胞。
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公开(公告)号：US20100183643A1
公开(公告)日：2010-07-22
申请号：US12462514
申请日：2009-08-05
CPC分类号： A61K9/127 , A61K9/0019 , A61K39/0011 , C07K14/4748
摘要： Disclosed are fragments of oncofetal antigen, otherwise known as immature laminin receptor protein that specifically stimulate one T cell subclass. The fragments may be formulated into compositions for potentiating T cell-mediated responses in mammalian cancer patients. They also have therapeutic uses in vitro.
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公开(公告)号：US07718762B2
公开(公告)日：2010-05-18
申请号：US10523277
申请日：2003-08-04
CPC分类号： A61K9/127 , A61K9/0019 , A61K39/0011 , C07K14/4748
摘要： Disclosed are fragments of oncofetal antigen, otherwise known as immature laminin receptor protein that specifically stimulate one T cell subclass. The fragments may be formulated into compositions for potentiating T cell-mediated responses in mammalian cancer patients. They also have therapeutic uses in vitro.
摘要翻译： 公开的是成纤维细胞抗原的片段，也称为特异性刺激一个T细胞亚类的未成熟层粘连蛋白受体蛋白。 这些片段可以配制成用于在哺乳动物癌症患者中增强T细胞介导的应答的组合物。 它们也具有体外治疗用途。
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公开(公告)号：US08709405B2
公开(公告)日：2014-04-29
申请号：US12462514
申请日：2009-08-05
IPC分类号： A61K35/12 , C12N5/0784
CPC分类号： A61K9/127 , A61K9/0019 , A61K39/0011 , C07K14/4748
摘要： Disclosed are fragments of oncofetal antigen, otherwise known as immature laminin receptor protein that specifically stimulate one T cell subclass. The fragments may be formulated into compositions for potentiating T cell-mediated responses in mammalian cancer patients. They also have therapeutic uses in vitro.
摘要翻译： 公开的是成纤维细胞抗原的片段，也称为特异性刺激一个T细胞亚类的未成熟层粘连蛋白受体蛋白。 这些片段可以配制成用于在哺乳动物癌症患者中增强T细胞介导的应答的组合物。 它们也具有体外治疗用途。
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6.发明授权Oncofetal antigen specific T-lymphocyte mediated immune response: manipulation and uses of oncofetal antigen specific CD4, CD8 cytotoxic and suppressor T cells and interleukin-10 有权Oncofetal抗原特异性T淋巴细胞介导的免疫应答：癌症抗原特异性CD4，CD8细胞毒性和抑制T细胞和白细胞介素-10的操作和用途公开(公告)号：US06534060B1
公开(公告)日：2003-03-18
申请号：US09702965
申请日：2000-10-31
IPC分类号： A61K3900
CPC分类号： G01N33/57476 , C07K16/244 , Y10S435/975
摘要： The present invention provides a method of determining the success of a cancer therapy in an individual, comprising the step of measuring the frequency of occurence of an oncofetal antigen-specific subclasses in the individual's peripheral blood. Also provided is a method of determining whether protective immunity against a tumor will develop in an individual, comprising the step of measuring the frequency of oncofetal antigen-specific T cells, tumor cells and macrophages at the site of the tumor which secrete IL-10. Additionally, a method of determining whether an individual having a tumor will go into remission or remain in remission, comprising the step of measuring the frequency of oncofetal antigen-specific Th1 cells, Tc cells and Ts cells, IL-10 and interferon-&ggr; secreting T cells in the peripheral blood.
摘要翻译： 本发明提供了确定个体癌症治疗成功的方法，包括测量个体外周血中癌胚抗原特异性亚类的发生频率的步骤。 还提供了确定个体中是否会发展针对肿瘤的保护性免疫的方法，包括测量在分泌IL-10的肿瘤部位的癌胚抗原特异性T细胞，肿瘤细胞和巨噬细胞的频率的步骤。 此外，确定具有肿瘤的个体是否将进入缓解或保持缓解的方法，包括测量癌胚抗原特异性Th1细胞，Tc细胞和Ts细胞，IL-10和干扰素-γ分泌的频率的步骤 外周血T细胞。
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