公开(公告)号：US08734817B2

公开(公告)日：2014-05-27

申请号：US13631399

申请日：2012-09-28

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Syed Faiyaz Ahmed Hossainy ,  Eugene Michal ,  Thierry Glauser ,  Connie Kwok ,  Stephen Dirk Pacetti

IPC: A61K9/00 ,  C08F251/00

CPC classification number: A61L31/10 ,  A61K31/727 ,  A61K31/728 ,  A61K31/785 ,  A61L31/16 ,  A61K2300/00 ,  C08L5/08 ,  C08L5/10

Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

公开(公告)号：US08906394B2

公开(公告)日：2014-12-09

申请号：US13631387

申请日：2012-09-28

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Syed Faiyaz Ahmed Hossainy ,  Eugene Michal ,  Thierry Glauser ,  Connie Kwok ,  Stephen Dirk Pacetti

IPC: A61K9/00 ,  A61F2/00 ,  C08F251/00 ,  A61L31/10 ,  A61K31/727 ,  A61K31/728 ,  A61K31/785

CPC classification number: A61L31/10 ,  A61K31/727 ,  A61K31/728 ,  A61K31/785 ,  A61L31/16 ,  A61K2300/00 ,  C08L5/08 ,  C08L5/10

Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.

Abstract translation: 提供了用于涂覆可植入装置的透明质酸（HA）缀合物或交联的HA组合物。 可植入装置可用于治疗动脉粥样硬化，血栓形成，再狭窄，高胆固醇，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管 梗阻，输尿管阻塞，肿瘤阻塞及其组合。

公开(公告)号：US08846836B2

公开(公告)日：2014-09-30

申请号：US13631026

申请日：2012-09-28

Applicant: Advanced Cardiovascular Systems, Inc.

Inventor： Thierry Glauser ,  Syed Faiyaz Ahmed Hossainy ,  Connie Kwok ,  Stephen Dirk Pacetti ,  Eugene Michal

IPC: A61F2/00 ,  C07H3/00 ,  C08B37/00 ,  C12P19/04 ,  A61K31/727 ,  A61K31/785 ,  A61K31/728 ,  A61L31/10

CPC classification number: A61L31/10 ,  A61K31/727 ,  A61K31/728 ,  A61K31/785 ,  A61L31/16 ,  A61K2300/00 ,  C08L5/08 ,  C08L5/10

Abstract: Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.