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公开(公告)号：US08846836B2
公开(公告)日：2014-09-30
申请号：US13631026
申请日：2012-09-28
发明人： Thierry Glauser , Syed Faiyaz Ahmed Hossainy , Connie Kwok , Stephen Dirk Pacetti , Eugene Michal
IPC分类号： A61F2/00 , C07H3/00 , C08B37/00 , C12P19/04 , A61K31/727 , A61K31/785 , A61K31/728 , A61L31/10
CPC分类号： A61L31/10 , A61K31/727 , A61K31/728 , A61K31/785 , A61L31/16 , A61K2300/00 , C08L5/08 , C08L5/10
摘要： Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
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2.发明授权Coatings for implantable devices comprising poly(hydroxy-alkanoates) and diacid linkages 有权用于可植入装置的涂料包括聚（羟基链烷酸酯）和二酸键公开(公告)号：US08758801B2
公开(公告)日：2014-06-24
申请号：US13686392
申请日：2012-11-27
CPC分类号： A61L31/10 , A61L27/34 , C08G63/66 , C09D167/00
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings including block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety.
摘要翻译： 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包括包含至少一种聚（羟基酸）或聚（羟基 - 链烷酸酯）嵌段的嵌段聚合物，至少一个生物相容性聚合物的嵌段和至少 一种类型的连接部分。
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3.发明申请Methods of forming coatings with a crystalline or partially crystalline drug for implantable medical devices using supercritical fluid assisted sorption 审中-公开使用超临界流体辅助吸附形成用于可植入医疗装置的结晶或部分结晶药物的涂层的方法公开(公告)号：US20130149430A1
公开(公告)日：2013-06-13
申请号：US13720667
申请日：2012-12-19
IPC分类号： B05D5/00
CPC分类号： B05D5/00 , A61F2/82 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/63 , A61L2420/02 , A61L2420/08 , C08L67/02
摘要： Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.
摘要翻译： 提供了在可植入装置上制备涂层的方法，例如药物洗脱支架，其包含聚合物和缓慢溶解多晶型物质中的药物的纳米或微粒，通过使用该涂层的方法和方法制备的可植入装置。
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公开(公告)号：US08734817B2
公开(公告)日：2014-05-27
申请号：US13631399
申请日：2012-09-28
发明人： Syed Faiyaz Ahmed Hossainy , Eugene Michal , Thierry Glauser , Connie Kwok , Stephen Dirk Pacetti
IPC分类号： A61K9/00 , C08F251/00
CPC分类号： A61L31/10 , A61K31/727 , A61K31/728 , A61K31/785 , A61L31/16 , A61K2300/00 , C08L5/08 , C08L5/10
摘要： Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
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5.发明申请Methods of Forming Coatings with a Crystalline or Partially Crystalline Drug for Implantable Medical Devices using Sonocrystallization 审中-公开使用结晶或部分结晶药物形成涂层的方法，用于使用声结晶的可植入医疗器械公开(公告)号：US20130142939A1
公开(公告)日：2013-06-06
申请号：US13718488
申请日：2012-12-18
IPC分类号： A61F2/82
CPC分类号： B05D5/00 , A61F2/82 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/63 , A61L2420/02 , A61L2420/08 , C08L67/02
摘要： Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.
摘要翻译： 提供了在可植入装置上制备涂层的方法，例如药物洗脱支架，其包含聚合物和缓慢溶解多晶型物质中的药物的纳米或微粒，通过使用该涂层的方法和方法制备的可植入装置。
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6.发明申请Methods of Forming Coatings with a Crystalline or Partially Crystalline Drug for Implantable Medical Devices 有权用可植入医疗器械的结晶或部分结晶药物形成涂层的方法公开(公告)号：US20130149431A1
公开(公告)日：2013-06-13
申请号：US13722644
申请日：2012-12-20
IPC分类号： A61L31/16
CPC分类号： B05D5/00 , A61F2/82 , A61L31/10 , A61L31/16 , A61L2300/416 , A61L2300/606 , A61L2300/63 , A61L2420/02 , A61L2420/08 , C08L67/02
摘要： Methods for making coatings on an implantable device such as a drug-eluting stent comprising a polymer and nano or microparticles of a drug in slow-dissolving polymorph, implantable devices produced by the methods and methods of using the coatings are provided.
摘要翻译： 提供了在可植入装置上制备涂层的方法，例如药物洗脱支架，其包含聚合物和缓慢溶解多晶型物质中的药物的纳米或微粒，通过使用该涂层的方法和方法制备的可植入装置。
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公开(公告)号：US08906394B2
公开(公告)日：2014-12-09
申请号：US13631387
申请日：2012-09-28
发明人： Syed Faiyaz Ahmed Hossainy , Eugene Michal , Thierry Glauser , Connie Kwok , Stephen Dirk Pacetti
IPC分类号： A61K9/00 , A61F2/00 , C08F251/00 , A61L31/10 , A61K31/727 , A61K31/728 , A61K31/785
CPC分类号： A61L31/10 , A61K31/727 , A61K31/728 , A61K31/785 , A61L31/16 , A61K2300/00 , C08L5/08 , C08L5/10
摘要： Hyaluronic acid (HA) conjugates or crosslinked HAs compositions for coating an implantable device are provided. The implantable device can be used for treating a disorder such as atherosclerosis, thrombosis, restenosis, high cholesterol, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, and combinations thereof.
摘要翻译： 提供了用于涂覆可植入装置的透明质酸（HA）缀合物或交联的HA组合物。 可植入装置可用于治疗动脉粥样硬化，血栓形成，再狭窄，高胆固醇，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等障碍，胆管 梗阻，输尿管阻塞，肿瘤阻塞及其组合。
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8.发明授权Coatings for implantable devices comprising poly(hydroxy-alkanoates) and diacid linkages 有权用于可植入装置的涂料包括聚（羟基链烷酸酯）和二酸键公开(公告)号：US08586075B2
公开(公告)日：2013-11-19
申请号：US13686380
申请日：2012-11-27
CPC分类号： A61L31/10 , A61L27/34 , C08G63/66 , C09D167/00
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings include block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety.
摘要翻译： 公开了用于植入式医疗装置的涂层及其制造方法，所述涂层包括包含至少一种聚（羟基酸）或聚（羟基 - 链烷酸酯）嵌段的至少一种生物相容性聚合物的至少一个嵌段 一种类型的连接部分。
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9.发明申请COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLY(HYDROXY-ALKANOATES) AND DIACID LINKAGES 有权用于包含聚（羟基 - 烷基）酸酯和双向连接的可植入装置的涂料公开(公告)号：US20130123422A1
公开(公告)日：2013-05-16
申请号：US13686380
申请日：2012-11-27
IPC分类号： A61L27/34
CPC分类号： A61L31/10 , A61L27/34 , C08G63/66 , C09D167/00
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings include block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety.
摘要翻译： 公开了用于植入式医疗装置的涂层及其制造方法，所述涂层包括包含至少一种聚（羟基酸）或聚（羟基 - 链烷酸酯）嵌段的至少一种生物相容性聚合物的至少一个嵌段 一种类型的连接部分。
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10.发明申请COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLY(HYDROXY-ALKANOATES) AND DIACID LINKAGES 有权用于包含聚（羟基 - 烷基）酸酯和双向连接的可植入装置的涂料公开(公告)号：US20130116380A1
公开(公告)日：2013-05-09
申请号：US13686392
申请日：2012-11-27
IPC分类号： C09D167/00
CPC分类号： A61L31/10 , A61L27/34 , C08G63/66 , C09D167/00
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings including block-polymers comprising at least one poly(hydroxyacid) or poly(hydroxy-alkanoate) block, at least one block of a biologically compatible polymer and at least one type of linking moiety.
摘要翻译： 公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包括包含至少一种聚（羟基酸）或聚（羟基 - 链烷酸酯）嵌段的嵌段聚合物，至少一个生物相容性聚合物的嵌段和至少 一种类型的连接部分。
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