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公开(公告)号：US11045552B2
公开(公告)日：2021-06-29
申请号：US15479071
申请日：2017-04-04
Applicant: International Business Machines Corporation , Agency for Science, Technology and Research (ASTAR)
Inventor： Dylan J. Boday , Jeannette M. Garcia , James L. Hedrick , Nathaniel H. Park , Rudy J. Wojtecki , Yang Chuan , Ashlynn Lee , Zhen Chang Liang , Shaoqiong Liu , Yi Yan Yang
Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.
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公开(公告)号：US11485823B2
公开(公告)日：2022-11-01
申请号：US16627094
申请日：2018-05-23
Applicant: Agency for Science, Technology and Research
Inventor： Yi-Yan Yang , Chuan Yang , Wei Cheng , Ashlynn Lee
Abstract: The present invention mainly relates to a polymer for delivery of biologically active materials, a complex and a method of synthesis thereof. The polymer comprises a poly(ethylene imine) and at least one monomer, each monomer comprising a modified sugar moiety, preferably galactose, comprising a sulphur atom or a nitrogen atom and a chemical moiety comprising a terminal epoxide for linking the polyethylene imine to the monomer, wherein the sulphur atom or the nitrogen atom links the modified sugar moiety to the chemical moiety. The biologically active material is preferably a gene, siRNA, mRNA or plasmid DNA. Further disclosed is the medical use of said complex in treating a disease caused by a genetic disorder, for example cancer.
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公开(公告)号：US11890342B2
公开(公告)日：2024-02-06
申请号：US17130415
申请日：2020-12-22
Applicant: International Business Machines Corporation , Agency for Science, Technology, and Research (ASTAR)
Inventor： Dylan J. Boday , Jeannette M. Garcia , James L. Hedrick , Nathaniel Park , Rudy J. Wojtecki , Yang Chuan , Ashlynn Lee , Zhen Chang Liang , Shaoqiong Liu , Yi Yan Yang
CPC classification number: A61K47/34 , A61K9/0019 , A61K9/107 , A61K31/7088 , A61K38/00 , A61K47/10 , C08G64/183
Abstract: A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.
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公开(公告)号：US20200165390A1
公开(公告)日：2020-05-28
申请号：US16627094
申请日：2018-05-23
Applicant: Agency for Science, Technology and Research
Inventor： Yi-Yan Yang , Chuan Yang , Wei Cheng , Ashlynn Lee
Abstract: The present invention mainly relates to a polymer for delivery of biologically active materials, a complex and a method of synthesis thereof. The polymer comprises a poly(ethylene imine) and at least one monomer, each monomer comprising a modified sugar moiety, preferably galactose, comprising a sulphur atom or a nitrogen atom and a chemical moiety comprising a terminal epoxide for linking the polyethylene imine to the monomer, wherein the sulphur atom or the nitrogen atom links the modified sugar moiety to the chemical moiety. The biologically active material is preferably a gene, siRNA, mRNA or plasmid DNA. Further disclosed is the medical use of said complex in treating a disease caused by a genetic disorder, for example cancer.
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