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1.发明授权Amphiphilic peptides comprising the formula I: (X1Y1X2Y2)n, and uses thereof 有权包含式I：（X1Y1X2Y2）n的两亲肽及其用途公开(公告)号：US09273096B2
公开(公告)日：2016-03-01
申请号：US14353531
申请日：2013-08-29
Applicant: Agency for Science, Technology and Research
Inventor： Yi-Yan Yang , Zhan Yuin Ong
CPC classification number: C07K7/08 , A01N47/44 , A61K38/00 , A61K38/08 , C07K7/06 , C07K14/4723 , Y02A50/385 , Y02A50/401 , Y02A50/402 , Y02A50/471 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/492 , A01N33/04
Abstract: Disclosed are amphiphilic peptides. Also disclosed are methods of treating proliferative disease, bacterial infection, viral infection and fungal infection, endotoxin neutralization and a method of removing biofilm. Also disclosed is the use of the amphiphilic peptides.
Abstract translation: 公开的是两亲肽。 还公开了治疗增殖性疾病，细菌感染，病毒感染和真菌感染，内毒素中和的方法，以及除去生物膜的方法。 还公开了两亲肽的用途。
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Patent Agency Ranking
公开(公告)号：US11485823B2
公开(公告)日：2022-11-01
申请号：US16627094
申请日：2018-05-23
Applicant: Agency for Science, Technology and Research
Inventor： Yi-Yan Yang , Chuan Yang , Wei Cheng , Ashlynn Lee
Abstract: The present invention mainly relates to a polymer for delivery of biologically active materials, a complex and a method of synthesis thereof. The polymer comprises a poly(ethylene imine) and at least one monomer, each monomer comprising a modified sugar moiety, preferably galactose, comprising a sulphur atom or a nitrogen atom and a chemical moiety comprising a terminal epoxide for linking the polyethylene imine to the monomer, wherein the sulphur atom or the nitrogen atom links the modified sugar moiety to the chemical moiety. The biologically active material is preferably a gene, siRNA, mRNA or plasmid DNA. Further disclosed is the medical use of said complex in treating a disease caused by a genetic disorder, for example cancer.
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公开(公告)号：US20150080289A1
公开(公告)日：2015-03-19
申请号：US14353531
申请日：2013-08-29
Applicant: Agency for Science, Technology and Research
Inventor： Yi-Yan Yang , Zhan Yuin Ong
CPC classification number: C07K7/08 , A01N47/44 , A61K38/00 , A61K38/08 , C07K7/06 , C07K14/4723 , Y02A50/385 , Y02A50/401 , Y02A50/402 , Y02A50/471 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/492 , A01N33/04
Abstract: Disclosed are amphiphilic peptides. Also disclosed are methods of treating proliferative disease, bacterial infection, viral infection and fungal infection, endotoxin neutralization and a method of removing biofilm. Also disclosed is the use of the amphiphilic peptides.
Abstract translation: 公开的是两亲肽。 还公开了治疗增殖性疾病，细菌感染，病毒感染和真菌感染，内毒素中和以及除去生物膜的方法的方法。 还公开了两亲肽的用途。
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公开(公告)号：US09221875B2
公开(公告)日：2015-12-29
申请号：US14321624
申请日：2014-07-01
Applicant: Agency for Science, Technology and Research
Inventor： Yi-Yan Yang , Zhan Yuin Ong
CPC classification number: C07K7/08 , A01N47/44 , A61K38/00 , A61K38/08 , C07K7/06 , C07K14/4723 , Y02A50/385 , Y02A50/401 , Y02A50/402 , Y02A50/471 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/492 , A01N33/04
Abstract: Disclosed is the method of treating keratits in a subject thereof comprising administering into the subject an amphiphilic peptides of the present disclosure. Also disclosed are methods of removing biofilm from cornea.
Abstract translation: 公开了治疗本发明的角蛋白的方法，其包括向受试者施用本公开的两亲性肽。 还公开了从角膜去除生物膜的方法。
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公开(公告)号：US20200165390A1
公开(公告)日：2020-05-28
申请号：US16627094
申请日：2018-05-23
Applicant: Agency for Science, Technology and Research
Inventor： Yi-Yan Yang , Chuan Yang , Wei Cheng , Ashlynn Lee
Abstract: The present invention mainly relates to a polymer for delivery of biologically active materials, a complex and a method of synthesis thereof. The polymer comprises a poly(ethylene imine) and at least one monomer, each monomer comprising a modified sugar moiety, preferably galactose, comprising a sulphur atom or a nitrogen atom and a chemical moiety comprising a terminal epoxide for linking the polyethylene imine to the monomer, wherein the sulphur atom or the nitrogen atom links the modified sugar moiety to the chemical moiety. The biologically active material is preferably a gene, siRNA, mRNA or plasmid DNA. Further disclosed is the medical use of said complex in treating a disease caused by a genetic disorder, for example cancer.
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公开(公告)号：US20150005228A1
公开(公告)日：2015-01-01
申请号：US14321624
申请日：2014-07-01
Applicant: Agency for Science, Technology and Research
Inventor： Yi-Yan Yang , Zhan Yuin Ong
CPC classification number: C07K7/08 , A01N47/44 , A61K38/00 , A61K38/08 , C07K7/06 , C07K14/4723 , Y02A50/385 , Y02A50/401 , Y02A50/402 , Y02A50/471 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/492 , A01N33/04
Abstract: Disclosed is the method of treating keratits in a subject thereof comprising administering into the subject an amphiphilic peptides of the present disclosure. Also disclosed are methods of removing biofilm from cornea.
Abstract translation: 公开了治疗本发明的角蛋白的方法，其包括向受试者施用本公开的两亲性肽。 还公开了从角膜去除生物膜的方法。
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