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公开(公告)号：US11045552B2
公开(公告)日：2021-06-29
申请号：US15479071
申请日：2017-04-04
申请人： International Business Machines Corporation , Agency for Science, Technology and Research (ASTAR)
发明人： Dylan J. Boday , Jeannette M. Garcia , James L. Hedrick , Nathaniel H. Park , Rudy J. Wojtecki , Yang Chuan , Ashlynn Lee , Zhen Chang Liang , Shaoqiong Liu , Yi Yan Yang
摘要： A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.
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公开(公告)号：US11890342B2
公开(公告)日：2024-02-06
申请号：US17130415
申请日：2020-12-22
申请人： International Business Machines Corporation , Agency for Science, Technology, and Research (ASTAR)
发明人： Dylan J. Boday , Jeannette M. Garcia , James L. Hedrick , Nathaniel Park , Rudy J. Wojtecki , Yang Chuan , Ashlynn Lee , Zhen Chang Liang , Shaoqiong Liu , Yi Yan Yang
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/107 , A61K31/7088 , A61K38/00 , A61K47/10 , C08G64/183
摘要： A stimulus-responsive micellar carrier, methods that may be associated with making a stimulus-responsive micellar carrier, and methods that may be associated with using a stimulus-responsive micellar carrier are disclosed. The stimulus-responsive micellar carrier comprises a cargo molecule, and a linear block copolymer having a hydrophilic block connected to a hydrophobic block by a stimulus-responsive junction moiety. The micellar carrier can be supplied to a patient body for therapeutic purposes, such as the treatment of cancerous tissue. A method of preparing or obtaining a stimulus-responsive micellar carrier may include preparing a polyethylene glycol material having an acetal end group and then preparing a block copolymer by forming a reaction mixture including the polyethylene glycol material, a cyclic carbonate monomer, and a base.
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公开(公告)号：US10457772B2
公开(公告)日：2019-10-29
申请号：US15699416
申请日：2017-09-08
申请人： International Business Machines Corporation , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (ASTAR)
发明人： Dylan J. Boday , Willy Chin , Jeannette M. Garcia , James L. Hedrick , Eunice Leong Jiayu , Shrinivas Venkataraman , Zhi Xiang Voo , Rudy J. Wojtecki , Yi Yan Yang
摘要： The present disclosure relates to polythioaminals with applications as carriers or delivery vehicles for therapeutic agents or other small molecule cargo. Polythioaminal block copolymer coupled to a therapeutic agent is a polymer-therapeutic conjugate that exhibits higher stability and longer life time in aqueous environments. The polythioaminal block copolymer coupled to a therapeutic agent can be synthesized by reacting hexahydrotriazines with a hydrophobic block precursor, a hydrophilic block precursor, a particle stabilizing segment precursor, and a cargo, such as a therapeutic agent, in a one pot synthesis. The ease of synthesizing the resulting polythioaminal block copolymer coupled to the therapeutic agent while offering the extended stability and polymer life time in aqueous environments make the polythioaminal block copolymer particularly attractive for therapeutic carriers.
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公开(公告)号：US11882770B2
公开(公告)日：2024-01-23
申请号：US17118192
申请日：2020-12-10
发明人： Rudy J. Wojtecki , Damon Brooks Farmer , Charles Thomas Rettner , Noel Arellano , Alexander Friz , Matthew W. Copel
IPC分类号： H10N60/01
CPC分类号： H10N60/0241
摘要： Embodiments are provided for fabrication of superconducting devices using area-selective deposition of a metal nitride. In some embodiments, a method can include providing a thermally treated carbon layer, and selectively depositing a metal nitride using the thermally treated carbon layer for formation of a superconducting device.
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公开(公告)号：US20230187342A1
公开(公告)日：2023-06-15
申请号：US17547669
申请日：2021-12-10
发明人： Nicholas Anthony Lanzillo , PRASAD BHOSALE , Alexander Edward Hess , SON NGUYEN , Rudy J. Wojtecki
IPC分类号： H01L23/522 , H01L21/768 , H01L21/3105
CPC分类号： H01L23/5226 , H01L21/76897 , H01L21/76879 , H01L21/31053 , H01L21/76883
摘要： A method of forming a fully-aligned via (FAV) structure is provided. The method includes arranging conductive material adjacent to a dielectric pad and chemically deactivating a surface of the conductive material by forming a dopant-free surface-aligned monolayer (SAM) thereon. Dielectric material is deposited onto the dielectric pad aside the dopant-free SAM and the dopant-free SAM is removed from the surface of the conductive material.
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6.发明授权公开(公告)号：US11647768B2
公开(公告)日：2023-05-16
申请号：US17095211
申请日：2020-11-11
发明人： Rudy J. Wojtecki
CPC分类号： A23L5/273 , A23F3/385 , A23F5/223 , B01J20/12 , B01J20/261 , B01J20/262 , A23V2002/00
摘要： A process of forming a treated clay composition, a process of decaffeination, and a treated clay composition are shown. The process of forming the treated clay composition includes providing a first solution of caffeine molecules and non-caffeine molecules, extracting the caffeine molecules to form a pretreatment solution, and bringing a clay composition into contact with the pretreatment solution to form the treated clay composition, on which at least one of the non-caffeine molecules is adsorbed. The process of decaffeination includes providing a solution of caffeine and non-caffeine molecules, and bringing the solution into contact with a treated clay composition. The treated clay composition includes organic molecules adsorbed on mineral layers of a clay. The organic molecules are non-caffeine molecules from a pretreatment solution.
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公开(公告)号：US11560484B2
公开(公告)日：2023-01-24
申请号：US16678076
申请日：2019-11-08
发明人： Amos Cahan , Hariklia Deligianni , Xin Ding , Mareva B. Fevre , James L. Hedrick , Pei-Yun S. Hsueh , Zhen Chang Liang , Nathaniel H. Park , Theodore G. van Kessel , Rudy J. Wojtecki , Yi Yan Yang
IPC分类号： C09D5/14 , A61M5/142 , C09D7/65 , B05D1/36 , C08G73/02 , A61C8/00 , A61F2/30 , B05D5/00 , A01N33/12 , A61B5/00 , A61F2/28 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61M5/14 , A61M27/00 , A61N1/378 , B05D3/00 , C08J3/24 , B05D1/02 , A61F2/07 , A61B1/00 , A61N1/36 , A61B17/56 , A61M25/00 , A61F2/01 , A61F2/48 , A61F2/06 , A61F2/14 , A61F2/24 , A61F2/82 , A61N1/362 , C09D179/02
摘要： Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.
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公开(公告)号：US10692755B2
公开(公告)日：2020-06-23
申请号：US16169121
申请日：2018-10-24
IPC分类号： H01L21/3205 , H01L21/768 , H01L21/027 , H01L21/311 , H01L21/033
摘要： A method for fabricating a semiconductor device includes forming a via in a first dielectric layer arranged on a metal layer. The via exposes a portion of the metal layer. The method includes forming a trench in the first dielectric layer. The method further includes depositing, by a selective process, a second dielectric layer on the first dielectric layer such that the second dielectric layer lines sidewalls of the via and the trench and is selectively deposited onto the first dielectric layer.
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公开(公告)号：US10563069B2
公开(公告)日：2020-02-18
申请号：US15474330
申请日：2017-03-30
发明人： Amos Cahan , Hariklia Deligianni , Xin Ding , Mareva B. Fevre , James L. Hedrick , Pei-Yun S. Hsueh , Zhen Chang Liang , Nathaniel H. Park , Theodore G. van Kessel , Rudy J. Wojtecki , Yi Yan Yang
IPC分类号： C09D5/14 , A01N33/12 , A61B5/00 , A61C8/00 , A61F2/28 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61M5/14 , A61M27/00 , A61N1/378 , B05D3/00 , C08J3/24 , A61F2/06 , A61F2/14 , A61F2/24 , A61F2/82 , A61F2/30 , A61M25/00 , A61N1/362 , C09D179/02
摘要： Antibacterial coatings and methods of making the antibacterial coatings are described herein. A first branched polyethylenimine (BPEI) layer is formed and a first glyoxal layer is formed on a surface of the BPEI layer. The first BPEI layer and the first glyoxal layer are cured to form a crosslinked BPEI coating. The first BPEI layer can be modified with superhydrophobic moieties, superhydrophilic moieties, or negatively charged moieties to increase the antifouling characteristics of the coating. The first BPEI layer can be modified with contact-killing bactericidal moieties to increase the bactericidal characteristics of the coating.
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公开(公告)号：US10557008B2
公开(公告)日：2020-02-11
申请号：US15815200
申请日：2017-11-16
摘要： A porous material includes a resin material based on a trifunctional ethynyl monomer. Pores in the porous material can be of various sizes including nanoscale sizes. The porous material may be used in a variety of applications, such as those requiring materials with a high strength-to-weight ratio. The porous material can include a filler material dispersed therein. The filler material can be, for example, a particle, a fiber, a fabric, or the like. In some examples, the filler material can be a carbon fiber or a carbon nanotube. A method of making a porous material includes forming a resin including a trifunctional ethynyl monomer component and a polythioaminal component. The resin can be heated to promote segregation of the components into different phases with predominately one or the other component in each phase. Processing of the resin after phase segregation to decompose the polythioaminal component can form pores in the resin.
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