公开(公告)号：US11529317B2

公开(公告)日：2022-12-20

申请号：US16499560

申请日：2018-03-28

Applicant: Agency for Science, Technology and Research

Inventor： Eun Ju Park ,  Alexander M. Van Herk ,  Praveen Thoniyot

IPC: A61K9/51 ,  A61K8/11 ,  A61K8/25 ,  A61Q19/00

Abstract: There is provided a method of preparing silica nanocapsules, the method comprising mixing a surfactant with water at a temperature that is above the gel-to-liquid transition temperature of the surfactant to form a mixture, passing the mixture one or more times through at least one pore to obtain a dispersion of vesicles, and adding a silica precursor to the dispersion of vesicles to form silica nanocapsules. Also provided is a silica nanocapsule formed from a vesicle template, and a method of delivering one or more types of molecules to a subject. In a specific embodiment, hollow silica nanocapsules having substantially lens-shaped are synthesized by employing dimethyldioctadecylammonium bromide (DODAB) or dioctadecyldimethyl ammonium chloride (DODAC) as the vesicle template and tetraethyl orthosilicate (TEOS) as the silica precursor.

公开(公告)号：US20230416468A1

公开(公告)日：2023-12-28

申请号：US18251108

申请日：2020-10-30

Applicant: Agency for Science, Technology and Research ,  Mitsui Chemicals, Inc.

Inventor： Peili Teo ,  Haruyuki Makio ,  Jiayi Guo ,  Eun Ju Park ,  Yew Chin Teo

IPC: C08G81/02 ,  A61K31/787

CPC classification number: C08G81/024 ,  A61K31/787

Abstract: There is provided a bioactive polyethylene copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a polyethylene macromolecule, a material comprising said bioactive polyethylene copolymer, a method of preparing said bioactive polyethylene copolymer and a method of preparing said polyethylene macromolecule.

公开(公告)号：US20230399457A1

公开(公告)日：2023-12-14

申请号：US18251144

申请日：2020-10-30

Applicant: Agency for Science, Technology and Research

Inventor： Peili Teo ,  Jiayi Guo ,  Yew Chin Teo ,  Eun Ju Park

IPC: C08G61/08

CPC classification number: C08G61/08 ,  C08G2261/122 ,  C08G2261/1426 ,  C08G2261/1432 ,  C08G2261/3342 ,  C08G2261/418

Abstract: There is provided a bioactive synthetic copolymer with a poly(norbornene) backbone comprising one or more repeating units represented by general formula (I) and one or more repeating units represented by general formula (II). Also provided are a bioactive macromolecule, a material comprising said bioactive synthetic copolymer, a method of preparing said bioactive synthetic copolymer and a method of preparing said bioactive macromolecule.