公开(公告)号：US12053754B2

公开(公告)日：2024-08-06

申请号：US17279001

申请日：2019-09-24

Applicant: Agency for Science, Technology and Research

Inventor： Praveen Thoniyot ,  Alexander M. Van Herk

IPC: B01J13/08 ,  C01B33/14

CPC classification number: B01J13/08 ,  C01B33/14

Abstract: There is provided a method of producing silica capsules, the method comprising: adding a silica precursor to emulsified droplets in the presence of salt and alcohol to enhance silica growth around the emulsified droplets by an ion association effect, thereby forming silica capsules. Also provided are silica capsules producible by such a method.

公开(公告)号：US11529317B2

公开(公告)日：2022-12-20

申请号：US16499560

申请日：2018-03-28

Applicant: Agency for Science, Technology and Research

Inventor： Eun Ju Park ,  Alexander M. Van Herk ,  Praveen Thoniyot

IPC: A61K9/51 ,  A61K8/11 ,  A61K8/25 ,  A61Q19/00

Abstract: There is provided a method of preparing silica nanocapsules, the method comprising mixing a surfactant with water at a temperature that is above the gel-to-liquid transition temperature of the surfactant to form a mixture, passing the mixture one or more times through at least one pore to obtain a dispersion of vesicles, and adding a silica precursor to the dispersion of vesicles to form silica nanocapsules. Also provided is a silica nanocapsule formed from a vesicle template, and a method of delivering one or more types of molecules to a subject. In a specific embodiment, hollow silica nanocapsules having substantially lens-shaped are synthesized by employing dimethyldioctadecylammonium bromide (DODAB) or dioctadecyldimethyl ammonium chloride (DODAC) as the vesicle template and tetraethyl orthosilicate (TEOS) as the silica precursor.

公开(公告)号：US11970563B2

公开(公告)日：2024-04-30

申请号：US16969808

申请日：2019-02-27

Applicant: Nanyang Technological University ,  Agency for Science, Technology and Research

Inventor： Atsushi Goto ,  Jit Sarkar ,  Longqiang Xiao ,  Feifei Li ,  Alexander M. Van Herk ,  Alexander William Jackson

IPC: C08F299/02 ,  C08F4/08 ,  C08F293/00 ,  A61K9/51 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: C08F299/024 ,  C08F4/08 ,  C08F293/005 ,  A61K9/5138 ,  B82Y30/00 ,  B82Y40/00

Abstract: The present invention relates to a nanoparticulate composition comprising nanoparticles formed from an amphipathic block copolymer comprising a hydrophilic block and a hydrophobic block, where the nanoparticles are provided in the form of micelles, cylindrical worm structures or vesicles and the size of the nanoparticles is from 25 to 500 nm, wherein: the composition is substantially free of heavy metals and compounds comprising sulfur. Also disclosed herein is a method of forming said nanoparticulate composition by polymerization induced self-assembly (PISA) via non-transition-metal catalysed controlled radical polymerization (NTMC-CRP).

公开(公告)号：US20220032254A1

公开(公告)日：2022-02-03

申请号：US17279001

申请日：2019-09-24

Applicant: Agency for Science, Technology and Research

Inventor： Praveen Thoniyot ,  Alexander M. Van Herk

IPC: B01J13/08 ,  C01B33/14

Abstract: There is provided a method of producing silica capsules, the method comprising: adding a silica precursor to emulsified droplets in the presence of salt and alcohol to enhance silica growth around the emulsified droplets by an ion association effect, thereby forming silica capsules. Also provided are silica capsules producible by such a method.

公开(公告)号：US11534375B2

公开(公告)日：2022-12-27

申请号：US16498284

申请日：2018-03-27

Applicant: Agency for Science, Technology and Research

Inventor： Praveen Thoniyot ,  Parijat Kanaujia ,  Alexander M. Van Herk

IPC: A61K8/11 ,  A61K8/02 ,  A61K8/90 ,  A61K9/107 ,  A61K9/51 ,  A61K45/06 ,  A61Q19/00 ,  A01N53/00

Abstract: Present disclosure relates to a solvent-free method of encapsulating a hydrophobic active in personal care, hydrophobic active in crop protection or a hydrophobic active pharmaceutical ingredient (API) in polymeric nanoparticles. The method includes mixing the hydrophobic active in a polymer melt, wherein the polymer melt comprises a melt of a block co-polymer, wherein the polymer melt acts as a solvent for the hydrophobic active. The method further includes maintaining the polymer melt in water for sufficient time to allow self-assembly of the block co-polymer to encapsulate the hydrophobic active therein.

公开(公告)号：US20200179248A1

公开(公告)日：2020-06-11

申请号：US16498284

申请日：2018-03-27

Applicant: Agency for Science, Technology and Research

Inventor： Praveen Thoniyot ,  Parijat Kanaujia ,  Alexander M. Van Herk

IPC: A61K8/11 ,  A61K8/02 ,  A61K9/107 ,  A61K8/90 ,  A61K9/51 ,  A61Q19/00 ,  A61K45/06

Abstract: Present disclosure relates to a solvent-free method of encapsulating a hydrophobic active in personal care, hydrophobic active in crop protection or a hydrophobic active pharmaceutical ingredient (API) in polymeric nanoparticles. The method includes mixing the hydrophobic active in a polymer melt, wherein the polymer melt comprises a melt of a block co-polymer, wherein the polymer melt acts as a solvent for the hydrophobic active. The method further includes maintaining the polymer melt in water for sufficient time to allow self-assembly of the block co-polymer to encapsulate the hydrophobic active therein.