公开(公告)号：US20250137069A1

公开(公告)日：2025-05-01

申请号：US18989874

申请日：2024-12-20

Applicant: Agency for Science, Technology and Research

Inventor： Bong Hwa GAN ,  Masafumi INOUE ,  Veronica DIERMAYR

IPC: C12Q1/6886 ,  A61K31/519 ,  A61K31/522

Abstract: The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, a method of identifying a subject suffering from a malignancy, a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, and a method of treating a subject with a malignancy.

公开(公告)号：US20200002772A1

公开(公告)日：2020-01-02

申请号：US16471320

申请日：2017-12-21

Applicant: Agency for Science, Technology and Research

Inventor： Bong Hwa GAN ,  Masafumi INOUE ,  Veronica DIERMAYR

IPC: C12Q1/6886 ,  A61K31/522 ,  A61K31/519

Abstract: The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, comprising a primer pair capable of amplifying a PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion. Also disclosed is a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, comprising detecting the PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion with a primer pair.

公开(公告)号：US20230366031A1

公开(公告)日：2023-11-16

申请号：US18131678

申请日：2023-04-06

Applicant: Agency for Science, Technology and Research

Inventor： Bong Hwa GAN ,  Masafumi INOUE ,  Veronica DIERMAYR

IPC: C12Q1/6886 ,  A61K31/519 ,  A61K31/522

CPC classification number: C12Q1/6886 ,  A61K31/519 ,  A61K31/522 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/16

Abstract: The present disclosure provides a multiplexed amplification reaction kit for identifying a subject suffering from a malignancy sensitive to treatment with an inhibitor of the Wnt signaling pathway, comprising a primer pair capable of amplifying a PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion. Also disclosed is a method of identifying sensitivity to an inhibitor of Wnt signaling in a subject suffering from a malignancy, comprising detecting the PTPRK(e13)-RSPO3(e2) R-Spondin gene-fusion with a primer pair.