公开(公告)号：US10466166B2

公开(公告)日：2019-11-05

申请号：US15311063

申请日：2015-05-28

Applicant: Agency for Science, Technology and Research

Inventor： Nikolai Yakovlev ,  Laura Sutarlie ,  Dave Siak-wei Ow ,  Tandiono Tandiono

IPC: G01N21/21 ,  G01N21/05

Abstract: According to one aspect of the invention, there is provided an ellipsometry system for measuring any one or more of molecular binding, adsorption and desorption on a substrate, the system comprising: a) a cuvette comprising i) a body within which a cavity is formed and an opening on the body, wherein the cavity extends into the opening through which the substrate is immersed; ii) a window formed on each of two oppositely located walls of the body, wherein the windows are aligned to allow light to enter through one of the two windows to reflect off the portion of the substrate immersed in the cavity and exit through the other of the two windows; iii) a channel arrangement enclosed within the body of the cuvette and comprising two non-contiguous portions, wherein one of the two non-contiguous portions guides fluid into the cavity and the other non-contiguous portion guides fluid out of the cavity; b) a polarized light source disposed to provide the light that enters into one of the two windows on the body of the cuvette; and c) a detection stage disposed to receive the light that exits through the other of the two windows on the body of the cuvette, wherein the detection stage is configured to measure polarization rotation of the received light, the polarization rotation caused by any one or more of molecular binding, adsorption and desorption occurring on the substrate surface. The detection stage preferably contains a polarization modulator, which is configured to measure polarization rotation of the received light.

公开(公告)号：US20200018690A1

公开(公告)日：2020-01-16

申请号：US16583198

申请日：2019-09-25

Applicant: Agency for Science, Technology and Research

Inventor： Nikolai Yakovlev ,  Laura Sutarlie ,  Dave Siak-wei Ow ,  Tandiono Tandiono

IPC: G01N21/21 ,  G01N21/05

Abstract: According to one aspect of the invention, there is provided an ellipsometry system for measuring any one or more of molecular binding, adsorption and desorption on a substrate, the system comprising: a) a cuvette comprising i) a body within which a cavity is formed and an opening on the body, wherein the cavity extends into the opening through which the substrate is immersed; ii) a window formed on each of two oppositely located walls of the body, wherein the windows are aligned to allow light to enter through one of the two windows to reflect off the portion of the substrate immersed in the cavity and exit through the other of the two windows; iii) a channel arrangement enclosed within the body of the cuvette and comprising two non-contiguous portions, wherein one of the two non-contiguous portions guides fluid into the cavity and the other non-contiguous portion guides fluid out of the cavity; b) a polarized light source disposed to provide the light that enters into one of the two windows on the body of the cuvette; and c) a detection stage disposed to receive the light that exits through the other of the two windows on the body of the cuvette, wherein the detection stage is configured to measure polarization rotation of the received light, the polarization rotation caused by any one or more of molecular binding, adsorption and desorption occurring on the substrate surface. The detection stage preferably contains a polarisation modulator, which is configured to measure polarization rotation of the received light.

公开(公告)号：US20170074781A1

公开(公告)日：2017-03-16

申请号：US15311063

申请日：2015-05-28

Applicant: Agency for Science, Technology and Research

Inventor： Nikolai Yakovlev ,  Laura Sutarlie ,  Dave Siak-wei Ow ,  Tandiono Tandiono

IPC: G01N21/21 ,  G01N21/05

CPC classification number: G01N21/211 ,  G01N21/05

Abstract: According to one aspect of the invention, there is provided an ellipsometry system for measuring any one or more of molecular binding, adsorption and desorption on a substrate, the system comprising: a) a cuvette comprising i) a body within which a cavity is formed and an opening on the body, wherein the cavity extends into the opening through which the substrate is immersed; ii) a window formed on each of two oppositely located walls of the body, wherein the windows are aligned to allow light to enter through one of the two windows to reflect off the portion of the substrate immersed in the cavity and exit through the other of the two windows; iii) a channel arrangement enclosed within the body of the cuvette and comprising two non-contiguous portions, wherein one of the two non-contiguous portions guides fluid into the cavity and the other non-contiguous portion guides fluid out of the cavity; b) a polarized light source disposed to provide the light that enters into one of the two windows on the body of the cuvette; and c) a detection stage disposed to receive the light that exits through the other of the two windows on the body of the cuvette, wherein the detection stage is configured to measure polarization rotation of the received light, the polarization rotation caused by any one or more of molecular binding, adsorption and desorption occurring on the substrate surface. The detection stage preferably contains a polarisation modulator, which is configured to measure polarization rotation of the received light.

Abstract translation: 根据本发明的一个方面，提供一种用于测量衬底上的分子结合，吸附和解吸中的任何一种或多种的椭偏仪系统，所述系统包括：a）比色皿，其包括i）形成空腔的体 以及在所述主体上的开口，其中所述空腔延伸到所述基底浸入所述开口中; ii）形成在所述主体的两个相对定位的壁中的每一个上的窗口，其中所述窗口对齐以允许光进入所述两个窗口中的一个窗口，以反射浸没在所述空腔中的所述基板的所述部分并且通过 两个窗户 iii）封闭在所述反应杯体内的通道布置并且包括两个非连续部分，其中所述两个非连续部分中的一个引导流体进入所述空腔，而另一非连续部分将流体引导出所述空腔; b）偏振光源，设置成提供进入比色杯身体的两个窗口之一的光; 以及c）检测台，被设置为接收通过所述比色皿主体上的两个窗口中的另一个窗口的光，其中所述检测台被配置为测量所接收的光的偏振旋转，由任何一个或 更多的分子结合，在衬底表面上发生吸附和解吸。 检测级优选地包含偏振调制器，其被配置为测量接收的光的偏振旋转。