中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

8 records (took 0.015 seconds)

    Ellipsometry system for measuring molecular binding, adsorption and desorption
    3.
    发明授权
    Ellipsometry system for measuring molecular binding, adsorption and desorption 有权

    公开(公告)号：US10466166B2

    公开(公告)日：2019-11-05

    申请号：US15311063

    申请日：2015-05-28

    Applicant: Agency for Science, Technology and Research

    Inventor： Nikolai Yakovlev ,  Laura Sutarlie ,  Dave Siak-wei Ow ,  Tandiono Tandiono

    IPC: G01N21/21 ,  G01N21/05

    Abstract: According to one aspect of the invention, there is provided an ellipsometry system for measuring any one or more of molecular binding, adsorption and desorption on a substrate, the system comprising: a) a cuvette comprising i) a body within which a cavity is formed and an opening on the body, wherein the cavity extends into the opening through which the substrate is immersed; ii) a window formed on each of two oppositely located walls of the body, wherein the windows are aligned to allow light to enter through one of the two windows to reflect off the portion of the substrate immersed in the cavity and exit through the other of the two windows; iii) a channel arrangement enclosed within the body of the cuvette and comprising two non-contiguous portions, wherein one of the two non-contiguous portions guides fluid into the cavity and the other non-contiguous portion guides fluid out of the cavity; b) a polarized light source disposed to provide the light that enters into one of the two windows on the body of the cuvette; and c) a detection stage disposed to receive the light that exits through the other of the two windows on the body of the cuvette, wherein the detection stage is configured to measure polarization rotation of the received light, the polarization rotation caused by any one or more of molecular binding, adsorption and desorption occurring on the substrate surface. The detection stage preferably contains a polarization modulator, which is configured to measure polarization rotation of the received light.

    Nanomaterial-based Bacterial Sensors
    6.
    发明申请
    Nanomaterial-based Bacterial Sensors 审中-公开

    公开(公告)号：US20200158642A1

    公开(公告)日：2020-05-21

    申请号：US16491960

    申请日：2018-03-27

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Laura Sutarlie ,  Sian Yang Ow ,  Shilin Chen ,  Xiaodi Su

    IPC: G01N21/64 ,  G01N33/542 ,  G01N33/569 ,  G01N15/06 ,  G01N21/359

    Abstract: This invention relates to a sensor that detects bacteria cells comprising (a) a primary negatively charged, nanoparticulate sensing material; (b) a secondary positively charged, fluorescent sensing material; (c) a housing; and (d) at least one illuminator; wherein said housing contains said primary negatively charged, nanoparticulate sensing material, said secondary positively charged fluorescent sensing material and a sample potentially comprising bacteria in aqueous medium, wherein said illuminator provides light of at least one pre-specified wavelength λi to excite at least said secondary positively charged, fluorescent material, wherein said secondary positively charged, fluorescent material electrostatically attached to bacteria cells provides at least one fluorescent response at a second different wavelength λn wherein both i and n are integers, wherein said negatively charged, nanoparticulate sensing material electrostatically attached to said fluorescent material suppresses fluorescing of said fluorescent material at said second wavelength λn; and wherein said housing permits illumination of the contents of said housing by said illuminator and wherein said housing further permits the detection of a fluorescent response at a second wavelength λn. The negatively charged material includes (dsDNA coated) spherical AuNPs and graphene oxide (GO). The positively charged fluorescent material includes water soluble cationic conjugated polyelectrolytes (COPE) or positively charged peptide/polymer labeled with fluorescence dye. The sensor makes use of the FRET phenomenon between the primary and secondary sensing materials. The sensor allows making a distinction between living and dead bacteria and can measure the total bacteria count. A method for detecting bacteria utilizing the sensor is another part of the invention.

    ELLIPSOMETRY SYSTEM FOR MEASURING MOLECULAR BINDING, ADSORPTION AND DESORPTION
    7.
    发明申请
    ELLIPSOMETRY SYSTEM FOR MEASURING MOLECULAR BINDING, ADSORPTION AND DESORPTION 审中-公开

    公开(公告)号：US20200018690A1

    公开(公告)日：2020-01-16

    申请号：US16583198

    申请日：2019-09-25

    Applicant: Agency for Science, Technology and Research

    Inventor： Nikolai Yakovlev ,  Laura Sutarlie ,  Dave Siak-wei Ow ,  Tandiono Tandiono

    IPC: G01N21/21 ,  G01N21/05

    Abstract: According to one aspect of the invention, there is provided an ellipsometry system for measuring any one or more of molecular binding, adsorption and desorption on a substrate, the system comprising: a) a cuvette comprising i) a body within which a cavity is formed and an opening on the body, wherein the cavity extends into the opening through which the substrate is immersed; ii) a window formed on each of two oppositely located walls of the body, wherein the windows are aligned to allow light to enter through one of the two windows to reflect off the portion of the substrate immersed in the cavity and exit through the other of the two windows; iii) a channel arrangement enclosed within the body of the cuvette and comprising two non-contiguous portions, wherein one of the two non-contiguous portions guides fluid into the cavity and the other non-contiguous portion guides fluid out of the cavity; b) a polarized light source disposed to provide the light that enters into one of the two windows on the body of the cuvette; and c) a detection stage disposed to receive the light that exits through the other of the two windows on the body of the cuvette, wherein the detection stage is configured to measure polarization rotation of the received light, the polarization rotation caused by any one or more of molecular binding, adsorption and desorption occurring on the substrate surface. The detection stage preferably contains a polarisation modulator, which is configured to measure polarization rotation of the received light.

    Ellipsometry System For Measuring Molecular Binding, Adsorption And Desorption
    8.
    发明申请
    Ellipsometry System For Measuring Molecular Binding, Adsorption And Desorption 审中-公开
    用于测量分子结合，吸附和解吸的椭偏仪系统

    公开(公告)号：US20170074781A1

    公开(公告)日：2017-03-16

    申请号：US15311063

    申请日：2015-05-28

    Applicant: Agency for Science, Technology and Research

    Inventor： Nikolai Yakovlev ,  Laura Sutarlie ,  Dave Siak-wei Ow ,  Tandiono Tandiono

    IPC: G01N21/21 ,  G01N21/05

    CPC classification number: G01N21/211 ,  G01N21/05

    Abstract: According to one aspect of the invention, there is provided an ellipsometry system for measuring any one or more of molecular binding, adsorption and desorption on a substrate, the system comprising: a) a cuvette comprising i) a body within which a cavity is formed and an opening on the body, wherein the cavity extends into the opening through which the substrate is immersed; ii) a window formed on each of two oppositely located walls of the body, wherein the windows are aligned to allow light to enter through one of the two windows to reflect off the portion of the substrate immersed in the cavity and exit through the other of the two windows; iii) a channel arrangement enclosed within the body of the cuvette and comprising two non-contiguous portions, wherein one of the two non-contiguous portions guides fluid into the cavity and the other non-contiguous portion guides fluid out of the cavity; b) a polarized light source disposed to provide the light that enters into one of the two windows on the body of the cuvette; and c) a detection stage disposed to receive the light that exits through the other of the two windows on the body of the cuvette, wherein the detection stage is configured to measure polarization rotation of the received light, the polarization rotation caused by any one or more of molecular binding, adsorption and desorption occurring on the substrate surface. The detection stage preferably contains a polarisation modulator, which is configured to measure polarization rotation of the received light.

    Abstract translation: 根据本发明的一个方面，提供一种用于测量衬底上的分子结合，吸附和解吸中的任何一种或多种的椭偏仪系统，所述系统包括：a）比色皿，其包括i）形成空腔的体 以及在所述主体上的开口，其中所述空腔延伸到所述基底浸入所述开口中; ii）形成在所述主体的两个相对定位的壁中的每一个上的窗口，其中所述窗口对齐以允许光进入所述两个窗口中的一个窗口，以反射浸没在所述空腔中的所述基板的所述部分并且通过 两个窗户 iii）封闭在所述反应杯体内的通道布置并且包括两个非连续部分，其中所述两个非连续部分中的一个引导流体进入所述空腔，而另一非连续部分将流体引导出所述空腔; b）偏振光源，设置成提供进入比色杯身体的两个窗口之一的光; 以及c）检测台，被设置为接收通过所述比色皿主体上的两个窗口中的另一个窗口的光，其中所述检测台被配置为测量所接收的光的偏振旋转，由任何一个或 更多的分子结合，在衬底表面上发生吸附和解吸。 检测级优选地包含偏振调制器，其被配置为测量接收的光的偏振旋转。

Patent Agency Ranking