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公开(公告)号：US11242385B2
公开(公告)日：2022-02-08
申请号：US15951950
申请日：2018-04-12
申请人： Agenus Inc.
发明人： Yanping Xiao , Nicholas Stuart Wilson , Benjamin Maxime Morin , Mark Arthur Findeis , Cornelia Anne Mundt , Marc van Dijk , Dhan Sidhartha Chand , David Adam Savitsky , Dennis John Underwood , Olga Ignatovich
IPC分类号： C12N15/13 , C07K16/28 , C12N15/09 , A61K47/68 , A61K39/395 , A61K45/06 , A61K51/10 , C07K16/46 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US11065317B2
公开(公告)日：2021-07-20
申请号：US16394812
申请日：2019-04-25
申请人： Agenus Inc.
摘要： Provided are polypeptides and compositions comprising novel HSP-binding peptides. Such polypeptides and compositions are particularly useful as immunotherapeutics (e.g., cancer vaccines). Also provided are methods of inducing a cellular immune response using such polypeptides and compositions, methods of treating a disease using such polypeptides and compositions, kits comprising such polypeptides and compositions, and methods of making such compositions.
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公开(公告)号：US20210106693A1
公开(公告)日：2021-04-15
申请号：US17094196
申请日：2020-11-10
申请人： Agenus Inc.
发明人： Yanping Xiao , Nicholas Stuart Wilson , Benjamin Maxime Morin , Mark Arthur Findeis , Cornelia Anne Mundt , Marc van Dijk , Dhan Sidhartha Chand , David Adam Savitsky , Dennis John Underwood , Olga Ignatovich
摘要： The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US20230014036A1
公开(公告)日：2023-01-19
申请号：US17818840
申请日：2022-08-10
申请人： AGENUS INC.
发明人： Dhan Sidhartha Chand , Zahra Jawad , Olga Ignatovich , Nicola Anne Ramsay , Spencer Campbell , Beth Wensley , Emmanuel Cyrille Pascal Briend , K. Mark Bushell , Benjamin Maxime Morin , Veronica Franciszka Ilkow
摘要： The instant disclosure provides multispecific molecules that specifically bind to CD96 (e.g., human CD96) and/or TIGIT (e.g., human TIGIT) and isolated antibodies that specifically bind to TIGIT (e.g., human TIGIT). Also provided are pharmaceutical compositions comprising these multispecific molecules and antibodies, nucleic acids encoding these multispecific molecules and antibodies, expression vectors and host cells for making these multispecific molecules and antibodies, and methods of treating a subject using these multispecific molecules and antibodies.
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公开(公告)号：US11098117B2
公开(公告)日：2021-08-24
申请号：US17094196
申请日：2020-11-10
申请人： Agenus Inc.
发明人： Yanping Xiao , Nicholas Stuart Wilson , Benjamin Maxime Morin , Mark Arthur Findeis , Cornelia Anne Mundt , Marc van Dijk , Dhan Sidhartha Chand , David Adam Savitsky , Dennis John Underwood , Olga Ignatovich
IPC分类号： C07K16/28 , C12N15/09 , A61K47/68 , A61K39/395 , A61K45/06 , A61K51/10 , C07K16/46 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US11021537B2
公开(公告)日：2021-06-01
申请号：US15968094
申请日：2018-05-01
申请人： Agenus Inc.
摘要： The instant disclosure provides antibodies that specifically bind to T-cell immunoreceptor with Ig and ITIM domains (TIGIT) (e.g., human TIGIT) and antagonize TIGIT function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US20200000905A1
公开(公告)日：2020-01-02
申请号：US16394812
申请日：2019-04-25
申请人： Agenus Inc.
摘要： Provided are polypeptides and compositions comprising novel HSP-binding peptides. Such polypeptides and compositions are particularly useful as immunotherapeutics (e.g., cancer vaccines). Also provided are methods of inducing a cellular immune response using such polypeptides and compositions, methods of treating a disease using such polypeptides and compositions, kits comprising such polypeptides and compositions, and methods of making such compositions.
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公开(公告)号：US20190352418A1
公开(公告)日：2019-11-21
申请号：US16296532
申请日：2019-03-08
申请人： Agenus Inc.
发明人： Nicholas Stuart Wilson , Jeremy Dale Waight , Shawn Michael Jennings , Olga Ignatovich , Emmanuel Cyrille Pascal Briend , Benjamin Maxime Morin , Oliver Schon , Spencer Campbell
摘要： The instant disclosure provides antibodies that specifically bind to CD73 (e.g., human CD73) and antagonize CD73 function. Also provided are anti-CD73 antibodies that further comprise a TGFβ-binding moiety or a VEGF-binding moiety. The instant disclosure additionally provides pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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