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    DERMAL DELIVERY DEVICE WITH IN SITU SEAL
    1.
    发明申请
    DERMAL DELIVERY DEVICE WITH IN SITU SEAL 有权
    带密封件的DERMAL DELIVERY设备

    公开(公告)号：US20130018337A1

    公开(公告)日：2013-01-17

    申请号：US13553362

    申请日：2012-07-19

    申请人： Agis KYDONIEUS ,  Robert G. CONWAY ,  Thomas M. ROSSI

    发明人： Agis KYDONIEUS ,  Robert G. CONWAY ,  Thomas M. ROSSI

    IPC分类号： A61M35/00

    CPC分类号： A61K9/7061 ,  A61F2013/00646 ,  A61K9/7084 ,  A61K31/566 ,  A61K31/567 ,  A61K31/568 ,  A61K31/573 ,  A61K47/14 ,  A61K47/20

    摘要： This invention relates to a transdermal drug delivery device that comprises an active ingredient (AI) layer, having a skin contacting surface and a non-skin contacting surface and comprising a volatile component, a release liner impermeable to the volatile component adjacent the skin contacting surface of the Al layer having a perimeter that extends beyond the perimeter of the AI layer in all directions, and an overlay comprising a pressure sensitive adhesive (PSA) that does not absorb the volatile component adjacent the non-skin contacting surface of the Al layer having a perimeter of which extends beyond the perimeter of the Al layer in all directions, wherein the release liner and the PSA of the overlay are in contact with and adhered to each other around the perimeter of the Al layer to form a seal that reduces or prevents volatile component loss.

    摘要翻译： 本发明涉及一种透皮药物递送装置，其包含活性成分（AI）层，其具有皮肤接触表面和非皮肤接触表面，并且包含挥发性成分，不透过皮肤接触表面的挥发性组分的剥离衬垫 的Al层具有在所有方向上延伸超过AI层的周边的周边，以及覆盖层，其包含不吸收与Al层的非皮肤接触表面相邻的挥发性组分的压敏粘合剂（PSA），所述粘合剂 其周边在所有方向上延伸超出Al层的周边，其中覆盖层的剥离衬垫和PSA与Al层的周边彼此接触并彼此粘附以形成密封，以减少或防止 挥发性成分损失。

    CONTRACEPTIVE METHOD
    3.
    发明申请
    CONTRACEPTIVE METHOD 审中-公开
    承办方式

    公开(公告)号：US20140256690A1

    公开(公告)日：2014-09-11

    申请号：US14201153

    申请日：2014-03-07

    申请人： Arkady RUBIN ,  Maria FOEGH ,  Agis KYDONIEUS ,  Thomas M. ROSSI

    发明人： Arkady RUBIN ,  Maria FOEGH ,  Agis KYDONIEUS ,  Thomas M. ROSSI

    IPC分类号： A61K9/70 ,  A61K31/565 ,  A61K31/567

    CPC分类号： A61K31/565 ,  A61K9/7061 ,  A61K31/567 ,  A61K2300/00

    摘要： A transdermal drug delivery device for reducing the risk of pregnancy in overweight women is disclosed. Methods of using the device are also disclosed. When used in accordance with the disclosed methods, the probability that the device will be effective in overweight women is approximately equal to or greater than the probability that the device would be effective in the case of a woman who is not overweight.

    摘要翻译： 公开了一种用于降低超重女性怀孕风险的透皮给药装置。 还公开了使用该装置的方法。 当根据所公开的方法使用时，设备在超重女性中有效的可能性大约等于或大于在不超重的女性的情况下该装置有效的概率。

    Dermal Delivery Compositions and Methods
    4.
    发明申请
    Dermal Delivery Compositions and Methods 有权
    皮肤输送成分和方法

    公开(公告)号：US20130116222A1

    公开(公告)日：2013-05-09

    申请号：US13667632

    申请日：2012-11-02

    申请人： Charles G. ARNOLD ,  Agis KYDONIEUS ,  Thomas M. ROSSI ,  Alfred F. ALTOMARI

    发明人： Charles G. ARNOLD ,  Agis KYDONIEUS ,  Thomas M. ROSSI ,  Alfred F. ALTOMARI

    IPC分类号： A61K31/567

    CPC分类号： A61K31/567 ,  A61K9/0014 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/57 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

    摘要： A composition for transdermal delivery of a progestin for progestin hormone therapy is disclosed. Also disclosed is a transdermal delivery device comprising the composition. For progestin-only hormone therapy, the composition contains an anti-oxidant and does not contain an estrogen. For therapy involving a progestin and an estrogen, the composition contains the progestin, the estrogen and an additional anti-oxidant. Methods of improving the stability of progestin-containing compositions comprising oxidative agents are also disclosed. The methods comprise including one or more anti-oxidants in the compositions.

    摘要翻译： 公开了用于孕激素治疗孕激素透皮递送的组合物。 还公开了包含该组合物的透皮递送装置。 对于仅孕激素治疗，该组合物含有抗氧化剂并且不含有雌激素。 对于涉及孕激素和雌激素的治疗​​，组合物含有孕激素，雌激素和另外的抗氧化剂。 还公开了改善含有孕激素的组合物包含氧化剂的稳定性的方法。 所述方法包括在组合物中包含一种或多种抗氧化剂。