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    Methods, compositions and articles for reducing or preventing the effects of inflammation
    4.
    发明授权
    Methods, compositions and articles for reducing or preventing the effects of inflammation 有权
    用于减少或预防炎症作用的方法，组合物和制品

    公开(公告)号：US06677366B2

    公开(公告)日：2004-01-13

    申请号：US09929558

    申请日：2001-08-13

    申请人： Anna M. Richter ,  Julia G. Levy ,  Claude A. A. Hariton ,  Gustave Huber ,  William C. Stewart ,  Mario G. Fsadni ,  Modestus O. K. Obochi

    发明人： Anna M. Richter ,  Julia G. Levy ,  Claude A. A. Hariton ,  Gustave Huber ,  William C. Stewart ,  Mario G. Fsadni ,  Modestus O. K. Obochi

    IPC分类号： A61K3140

    CPC分类号： A61K41/0071 ,  Y10S514/912

    摘要： A method for reducing or preventing the effects of inflammation arising from injured tissue, which method comprises the steps of: a. bringing the injured tissue, or pre-injured tissue, into contact with a photosensitizing agent capable of penetrating into the tissue, resulting in the desired degree of biodistribution in less than one hour; and b. exposing the tissue thus contacted to light having a wavelength absorbed by the photosensitizing agent for a time sufficient to reduce or prevent inflammation in the exposed tissue, but not so long as to cause necrosis or erythema of the exposed tissue, or a pharmaceutical composition or an article for reducing or preventing the effects of inflammation arising from injured tissue. The composition comprises: a. from about 1 &mgr;g/mL to about 2 mg/mL of a photosensitizing agent capable of penetrating into the injured tissue, or pre-injured tissue, resulting in the desired degree of biodistribution less than one hour; and b. a pharmaceutically acceptable carrier. The article comprises: a. a photosensitizing agent capable of penetrating into the injured tissue, or pre-injured tissue, resulting in the desired degree of biodistribution in less than one hour; and b. an absorbent applicator.

    摘要翻译： 一种减少或防止受损组织引起的炎症影响的方法，该方法包括以下步骤：a。 使损伤的组织或预损伤的组织与能够渗透到组织中的光敏剂接触，在少于1小时内产生所需程度的生物分布; 安布 将由此与光敏剂吸收的波长接触的组织暴露于足以减少或防止暴露组织中的炎症的时间，但不会导致暴露组织的坏死或红斑，或药物组合物或 用于减少或预防由损伤组织引起的炎症影响的制品。组合物包括：a。 约1ml / mL至约2mg / mL的能够渗入损伤组织或预损伤组织的光敏剂，导致所需程度的生物分布小于1小时; 安布 药学上可接受的载体。 能够渗入损伤组织或预损伤组织的光敏剂，在少于1小时内产生所需程度的生物分布; 安布 吸收性涂抹器。

    Method to prevent transplant rejection
    7.
    发明授权
    Method to prevent transplant rejection 失效
    防止移植排斥的方法

    公开(公告)号：US5882328A

    公开(公告)日：1999-03-16

    申请号：US759318

    申请日：1996-12-02

    申请人： Julia G. Levy ,  Modestus O. K. Obochi

    发明人： Julia G. Levy ,  Modestus O. K. Obochi

    IPC分类号： C07D487/22 ,  A61K41/00 ,  A61K45/00 ,  A61P37/06 ,  A61N1/30 ,  A61M31/00

    CPC分类号： A61K41/0071 ,  Y10S424/81

    摘要： Donor tissue containing antigen-presenting cells (APCs) can be modified to reduce rejection when the donor tissue is used as an allograft by exposing the donor tissue which has been treated with a photosensitizing agent having an absorption maximum between 400-900 nm to a wavelength absorbed by the photosensitizing agent so as to attenuate the APCs in the donor tissue but wherein the light is not cytotoxic to the APCs.

    摘要翻译： 当将供体组织用作同种异体移植物时，含有抗原呈递细胞（APCs）的供体组织可以被修饰以减少排斥，所述供体组织通过将已经用吸光度最大值在400-900nm之间的光敏剂处理的供体组织暴露于波长 由光敏剂吸收，以减弱供体组织中的APC，但其中光不对APC产生细胞毒性。