Cell analysis using laser with external cavity
    1.
    发明申请
    Cell analysis using laser with external cavity 有权
    使用外腔激光进行细胞分析

    公开(公告)号:US20060268260A1

    公开(公告)日:2006-11-30

    申请号:US11139610

    申请日:2005-05-31

    IPC分类号: G01N21/00

    摘要: An apparatus and method for analyzing biological cells and other particles using an external laser cavity. Microfluidic channels contain and transport biological cells to be analyzed. A laser diode provides light for cell analysis. An external cavity is provided between one surface of the laser diode and a mirror opposite thereto. A microlens set focuses the light on only one cell as it passes through the external cavity. The presence of the cell in the external cavity gives a weak feedback toward the laser diode. The emission frequency and the output power of the laser are both functions of the length of the external cavity. Therefore, the variation of cavity length can be deduced from these parameters, where the variation is caused by changing the refractive index or size of the cell in the cavity.

    摘要翻译: 使用外部激光腔分析生物细胞和其他颗粒的装置和方法。 微流体通道含有并转运待分析的生物细胞。 激光二极管为光源分析提供光源。 在激光二极管的一个表面和与之相对的镜子之间设置一个外部空腔。 微透镜组在通过外部空腔时将光聚焦在仅一个单元上。 外部腔中存在电池给激光二极管带来弱反馈。 激光器的发射频率和输出功率都是外腔长度的函数。 因此,可以从这些参数推导出腔长度的变化,其中通过改变空腔中的电池的折射率或尺寸引起变化。