公开(公告)号：US20240165260A1

公开(公告)日：2024-05-23

申请号：US18523499

申请日：2023-11-29

Applicant: Ajinomoto Co., Inc.

Inventor： Yutaka MATSUDA ,  Tomohiro FUJII ,  Ryusuke HIRAMA ,  Thomas MARKOTAN ,  Allan PRIOR ,  Christopher WONG ,  Konstantinos PLAKAS ,  Tomohiro WATANABE

IPC: A61K47/68 ,  C07K5/062

CPC classification number: A61K47/6889 ,  A61K47/68031 ,  A61K47/6855 ,  C07K5/06052

Abstract: A conjugate of an antibody and a functional substance or a salt thereof, which comprises a structural unit represented by the following formula (I):






wherein Ig represents an immunoglobulin unit comprising two heavy chains and two light chains, and regioselectively forms an amide bond with a carbonyl group adjacent to Ig via an amino group in side chains of lysine residues in the two heavy chains,
L1 and L2 each represent a divalent group,
R1 represents a monovalent group optionally comprising a hydrophilic group,
X represents a predetermined divalent group,
D represents a functional substance,
RA represents a side chain of a valine residue,
RB represents a side chain of a citrulline residue or an alanine residue,
n is 0 or 1, and
an average ratio r of the amide bonds per two heavy chains is 1.5 to 2.5, and
wherein at least one hydrophilic group is present in the structural unit are excellent in desired properties while controlling a binding ratio between the antibody and the functional substance within a desired range.