公开(公告)号：US09192624B2

公开(公告)日：2015-11-24

申请号：US13911776

申请日：2013-06-06

申请人： Ajinomoto Co., Inc.

发明人： Manabu Kitazawa ,  Satoru Ohashi ,  Yoko Masuzawa ,  Kousaku Ohkawa ,  Yasuhiko Tabata

IPC分类号： A61K31/785 ,  D01F6/68 ,  A61L27/18 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  A61L27/00 ,  D01D5/00

CPC分类号： A61K31/785 ,  A61L27/00 ,  A61L27/18 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  D01D5/0038 ,  D01F6/68 ,  C08L77/00

摘要： The present invention aims to provide a medical material which is safe for the live body, has high biocompatibility and is useful for promotion of cell differentiation. The present invention produces a medical material for promoting cell differentiation, which contains polyamino acid as a main component, wherein the polyamino acid contains at least one kind of amino acid residue selected from the group consisting of an alanine residue, a valine residue, a leucine residue, an isoleucine residue, a phenylalanine residue, a glycine residue, a glutamine residue, an aspartic acid residue optionally containing a protecting group in the side chain, a tyrosine residue optionally containing a protecting group in the side chain, a tryptophan residue optionally containing a protecting group in the side chain, a lysine residue optionally containing a protecting group in the side chain, and a glutamic acid residue optionally containing a protecting group in the side chain.

摘要翻译： 本发明的目的在于提供对活体安全的医疗用材料，具有高的生物相容性，对促进细胞分化是有用的。 本发明生产含有聚氨基酸作为主要成分的促进细胞分化的医药材料，其中聚氨基酸含有选自丙氨酸残基，缬氨酸残基，亮氨酸中的至少一种氨基酸残基 残基，异亮氨酸残基，苯丙氨酸残基，甘氨酸残基，谷氨酰胺残基，任选含有侧链保护基的天冬氨酸残基，任选地含有侧链保护基的酪氨酸残基，任选含有 侧链中的保护基，任选地含有侧链保护基的赖氨酸残基，以及任选地在侧链中含有保护基的谷氨酸残基。

公开(公告)号：US20130266620A1

公开(公告)日：2013-10-10

申请号：US13911776

申请日：2013-06-06

申请人： Ajinomoto Co., Inc.

发明人： Manabu Kitazawa ,  Satoru Ohashi ,  Yoko Masuzawa ,  Kousaku Ohkawa ,  Yasuhiko Tabata

IPC分类号： A61K31/785 ,  A61L27/00

CPC分类号： A61K31/785 ,  A61L27/00 ,  A61L27/18 ,  A61L27/34 ,  A61L31/06 ,  A61L31/10 ,  D01D5/0038 ,  D01F6/68 ,  C08L77/00

摘要： The present invention aims to provide a medical material which is safe for the live body, has high biocompatibility and is useful for promotion of cell differentiation. The present invention produces a medical material for promoting cell differentiation, which contains polyamino acid as a main component, wherein the polyamino acid contains at least one kind of amino acid residue selected from the group consisting of an alanine residue, a valine residue, a leucine residue, an isoleucine residue, a phenylalanine residue, a glycine residue, a glutamine residue, an aspartic acid residue optionally containing a protecting group in the side chain, a tyrosine residue optionally containing a protecting group in the side chain, a tryptophan residue optionally containing a protecting group in the side chain, a lysine residue optionally containing a protecting group in the side chain, and a glutamic acid residue optionally containing a protecting group in the side chain.

摘要翻译： 本发明的目的在于提供对活体安全的医疗用材料，具有高的生物相容性，对促进细胞分化是有用的。 本发明生产含有聚氨基酸作为主要成分的促进细胞分化的医药材料，其中聚氨基酸含有选自丙氨酸残基，缬氨酸残基，亮氨酸中的至少一种氨基酸残基 残基，异亮氨酸残基，苯丙氨酸残基，甘氨酸残基，谷氨酰胺残基，任选含有侧链保护基的天冬氨酸残基，任选地含有侧链保护基的酪氨酸残基，任选含有 侧链中的保护基，任选地含有侧链保护基的赖氨酸残基，以及任选地在侧链中含有保护基的谷氨酸残基。