公开(公告)号：US12024549B2

公开(公告)日：2024-07-02

申请号：US16663791

申请日：2019-10-25

申请人： Ajinomoto Co., Inc.

发明人： Kei Yamada ,  Yutaka Matsuda ,  Tomohiro Fujii ,  Natsuki Shikida ,  Reiko Yuji ,  Kazutaka Shimbo ,  Yuji Ito

IPC分类号： C07K16/00 ,  C07K19/00

CPC分类号： C07K16/00 ,  C07K19/00 ,  C07K2317/52

摘要： The present invention provides a technique enabling modification of a soluble protein and in particular regioselective modification of a soluble protein. More specifically, the present invention provides a compound having an affinity substance to a soluble protein, a cleavable portion, and a reactive group represented by the following Formula (I):

A-L-B-R  (I)



wherein

A is an affinity substance to a soluble protein;
L is a cleavable linker which is a divalent group comprising a cleavable portion;
B is (a) a divalent group comprising a bioorthogonal functional group or (b) a divalent group comprising no bioorthogonal functional group; and
R is a reactive group to the soluble protein; or
a salt thereof.