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公开(公告)号：US07660626B2
公开(公告)日：2010-02-09
申请号：US11195364
申请日：2005-08-02
申请人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
发明人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.
摘要翻译： 本发明提供了具有药物高效给药的离子电渗疗法装置。 一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于 药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。
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公开(公告)号：US20060173401A1
公开(公告)日：2006-08-03
申请号：US11195364
申请日：2005-08-02
申请人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
发明人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.
摘要翻译： 本发明提供了具有药物高效给药的离子电渗疗法装置。 一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于 药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。
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3.发明申请External preparation, method of applying external preparation, iontophoresis device, and percutaneous patch 审中-公开外用剂，外用剂的应用方法，离子电渗疗法及经皮贴剂公开(公告)号：US20060235351A1
公开(公告)日：2006-10-19
申请号：US11195351
申请日：2005-08-02
申请人： Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Kazuyuki Tsuji , Tsutomu Shibata , Akihiko Tanioka , Mie Minagawa
发明人： Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Kazuyuki Tsuji , Tsutomu Shibata , Akihiko Tanioka , Mie Minagawa
IPC分类号： A61N1/30 , A61K31/785 , A61K31/717
CPC分类号： A61N1/0444 , A61K9/0009 , A61K9/7023
摘要： The administration efficiency of a drug may be improved by establishing compatibility between the suppression of the release of a biological counter ion from a living body's biological interface and the maintenance of a good state of contact between each of a working electrode structure and a nonworking electrode structure and the biological interface. Coating films each composed of an external preparation containing: a hydrophilic polymer matrix agent; and an ion-exchange resin dispersed in the hydrophilic polymer matrix agent, or coating films each composed of an external preparation containing a hydrophilic polymer having an ion-exchange function are formed on the biological interface, and iontophoresis is performed through the coating films.
摘要翻译： 药物的给药效率可以通过建立抑制生物体离子从活体生物界面的释放与维持工作电极结构和非工作电极结构之间的良好接触状态之间的相容性来改善 和生物界面。 涂膜各自由外用制剂组成，含有：亲水性聚合物基质剂; 在亲水性聚合物基质剂中分散有离子交换树脂，或者在生物界面上形成各自由含有具有离子交换功能的亲水性聚合物的外用制剂构成的涂膜，通过涂膜进行离子电渗疗法。
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公开(公告)号：US20100100031A1
公开(公告)日：2010-04-22
申请号：US12643720
申请日：2009-12-21
申请人： Akihiko Tanioka , Mie Minegawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
发明人： Akihiko Tanioka , Mie Minegawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.
摘要翻译： 本发明提供了具有药物高效给药的离子电渗疗法装置。 一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于 药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。
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公开(公告)号：US20090216175A1
公开(公告)日：2009-08-27
申请号：US11917733
申请日：2006-08-04
申请人： Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Akihiko Matsumura , Kiyoshi Kanamura , Akihiko Tanioka
发明人： Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Akihiko Matsumura , Kiyoshi Kanamura , Akihiko Tanioka
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0428 , A61N1/0436 , A61N1/0448
摘要： To provide a transdermal administration device capable of increasing the speed at which a drug is transferred into a skin and the amount of the drug to be transferred into the skin. A transdermal administration device is constituted by: an electrode supplied with a voltage of a first conductivity type; an electrolyte solution holding portion holding an electrolyte solution energized by the electrode; and a bipolar membrane that is placed on the front surface side of the electrolyte solution holding portion, and is composed of a first ion exchange membrane that selectively passes an ion of the first conductivity type and a second ion exchange membrane that selectively passes an ion of a second conductivity type.
摘要翻译： 提供能够增加药物转移到皮肤中的速度和要转移到皮肤中的药物的量的透皮给药装置。 透皮给药装置由以下部分构成：供给第一导电型电压的电极; 电解液保持部，其保持由所述电极通电的电解液; 以及放置在电解液保持部的前表面侧的双极性膜，其由选择性地通过第一导电类型的离子的第一离子交换膜和选择性地通过第一导电类型的离子的第二离子交换膜 第二导电类型。
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6.发明申请公开(公告)号：US20070027426A1
公开(公告)日：2007-02-01
申请号：US11475838
申请日：2006-06-26
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0436 , A61N1/0448
摘要： An iontophoresis device includes an active electrode assembly which comprises an active electrode element and an outermost active electrode ion selective membrane that caches an active agent. The outermost active electrode ion selective membrane may be formed by one or more ion exchange membranes. The active electrode assembly may also comprise an electrolyte and/or one or more inner active electrode ion selective membranes. The inner active electrode ion selective membrane may be a “leaky” ion selective membrane. The inner active electrode ion exchange membrane may be spaced from the outermost active electrode ion selective membrane, for example, by one or more non-ion selective porous membranes or by a buffer material and/or buffer reservoir. An iontophoresis device may also include a counter electrode assembly and/or voltage source.
摘要翻译： 离子电渗装置包括活性电极组件，其包括活性电极元件和缓冲活性剂的最外面的活性电极离子选择性膜。 最外面的活性电极离子选择膜可以由一个或多个离子交换膜形成。 有源电极组件还可以包括电解质和/或一个或多个内部有源电极离子选择膜。 内部活性电极离子选择性膜可以是“泄漏”离子选择性膜。 内部有源电极离子交换膜可以与最外面的有源电极离子选择膜间隔开，例如通过一个或多个非离子选择性多孔膜或通过缓冲材料和/或缓冲储器隔开。 离子电渗装置还可以包括对电极组件和/或电压源。
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7.发明申请Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same 审中-公开具有形状记忆分离器和使用其的离子电渗装置的离子电渗电极组件公开(公告)号：US20090299265A1
公开(公告)日：2009-12-03
申请号：US11992672
申请日：2006-10-02
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/044 , A61N1/0448
摘要： An electrode assembly for iontophoresis including an electrode coupled to an electric power source device having a same polarity as that of the ionic drug in the electrode assembly, an electrolyte solution holding portion holding an electrolyte solution by being impregnated with the electrolyte solution, the electrolyte solution holding portion being placed adjacent to the electrode, a first ion exchange membrane operable to substantially pass ions having a polarity that is same as a polarity of the ionic drug and substantially block ions having a polarity that is opposite the polarity of the ionic drug, the first ion exchange membrane being placed adjacent to the electrolyte solution holding portion, a drug solution holding portion holding the ionic drug by being impregnated with the ionic drug, the drug solution holding portion being placed adjacent to the first ion exchange membrane, a second ion exchange membrane operable to substantially pass ions having a polarity that is opposite the polarity of the ionic drug and substantially block ions having a polarity that is the same as the polarity of the ionic drug, the second ion exchange membrane being placed adjacent to the drug solution holding portion, and a shape-memory separator capable of being transformed between a first and a second configuration to respectively allow passage of a substance and blocking of the substance, the shape-memory separator placed adjacent to at least one surface of the first ion exchange membrane.
摘要翻译： 一种用于离子电渗疗法的电极组件，其包括与电极组件中的离子药物极性相同的电源装置的电极，通过浸渍电解质溶液保持电解质溶液的电解液保持部分， 保持部分被放置成与电极相邻，第一离子交换膜可操作以基本上通过具有与离子药物的极性相同的极性的离子，并且基本上阻挡具有与离子药物的极性相反的极性的离子， 第一离子交换膜与电解质溶液保持部相邻配置，通过浸渍离子性药物而保持离子性药物的药液保持部，药液保持部与第一离子交换膜相邻配置，第二离子交换 膜可操作以基本上通过具有相反极性的离子 e离子药物的极性，并且基本上阻挡具有与离子药物的极性相同的极性的离子，第二离子交换膜邻近药物溶液保持部分放置，以及形状记忆分离器，其能够 在第一和第二构型之间转换以分别允许物质的通过和物质的阻塞，所述形状记忆隔离物与第一离子交换膜的至少一个表面相邻放置。
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公开(公告)号：US20070066930A1
公开(公告)日：2007-03-22
申请号：US11471973
申请日：2006-06-20
CPC分类号： A61N1/0444 , A61N1/044 , A61N1/0448
摘要： An iontophoresis device and method of producing the same may reduce material loss during the course of production of a conventional iontophoresis device, and may allow for easy automation of production processes and increases in production scale. The iontophoresis device may be used for administering drug ions of a first polarity generated by dissociation of a drug to a living body, and may comprise: a first conductive layer formed on a surface of a first substrate; a drug layer made of a drug coating containing the drug, the drug layer being laminated on the first conductive layer; and a first ion exchange layer made of an ion exchange coating containing an ion exchange resin having an exchange group introduced thereto, the ion exchange group having a counter ion to the first polarity ions, the first ion exchange layer being laminated on the drug layer.
摘要翻译： 离子电渗装置及其制造方法可以在常规离子电渗装置的制造过程中减少材料损失，并且可以容易地实现生产方法的自动化和生产规模的增加。 离子电渗装置可以用于施用通过将药物解离为活体而产生的第一极性的药物离子，并且可以包括：形成在第一基底的表面上的第一导电层; 由含有药物的药物涂层制成的药物层，所述药物层被层压在所述第一导电层上; 以及第一离子交换层，其由含有引入了交换基团的离子交换树脂的离子交换涂层构成，所述离子交换基团与所述第一极性离子具有抗衡离子，所述第一离子交换层层叠在所述药物层上。
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公开(公告)号：US20070066931A1
公开(公告)日：2007-03-22
申请号：US11501176
申请日：2006-08-07
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/0444
摘要： An iontophoresis device may be capable of preventing or reducing the generation of gas, or the production of undesirable ions, due to an electrode reaction occurring in an electrode assembly; or the alteration of an active agent due to a chemical reaction upon energization. A doping layer made of a substance such as a conductive polymer that effects an electrochemical reaction due to the doping or de-doping of an ion, may be formed in an electrode in an active electrode assembly or counter electrode assembly of an iontophoresis device.
摘要翻译： 离子电渗装置可以由于在电极组件中发生电极反应而能够防止或减少气体的产生或不需要的离子的产生; 或由于通电时的化学反应引起的活性剂的改变。 可以在离子电渗装置的有源电极组件或对电极组件中的电极中形成由诸如导电聚合物的物质制成的掺杂层，其由于离子的掺杂或去掺杂而实现电化学反应。
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公开(公告)号：US20070060859A1
公开(公告)日：2007-03-15
申请号：US11501672
申请日：2006-08-08
申请人： Kiyoshi Kanamura , Nobuharu Kosiba , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Kiyoshi Kanamura , Nobuharu Kosiba , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044 , A61N1/0444 , A61N1/0448
摘要： An iontophoresis device including an active electrode assembly or a counter electrode assembly with a polarizable electrode containing any one of a conductive material having a capacitance per unit weight of 1 F/g or greater, a conductive material having a specific surface area of 10 m2/g or greater, and activated carbon is disclosed. The generation of gas or ions due to an electrode reaction occurring in an electrode assembly may be reduced or prevented. In addition, the alteration of an active agent due to a chemical reaction upon energization may be reduced or prevented.
摘要翻译： 1.一种离子电渗疗法装置，其特征在于，包括具有可极化电极的活性电极组件或对电极组件，所述可极化电极含有每单位重量的电容为1F / g以上的导电材料，比表面积为10m 2 / g以上，并且公开了活性炭。 可以减少或防止由于在电极组件中发生电极反应而产生气体或离子。 此外，可以减少或防止由于通电时的化学反应引起的活性剂的改变。
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