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公开(公告)号：US20070060859A1
公开(公告)日：2007-03-15
申请号：US11501672
申请日：2006-08-08
申请人： Kiyoshi Kanamura , Nobuharu Kosiba , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Kiyoshi Kanamura , Nobuharu Kosiba , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044 , A61N1/0444 , A61N1/0448
摘要： An iontophoresis device including an active electrode assembly or a counter electrode assembly with a polarizable electrode containing any one of a conductive material having a capacitance per unit weight of 1 F/g or greater, a conductive material having a specific surface area of 10 m2/g or greater, and activated carbon is disclosed. The generation of gas or ions due to an electrode reaction occurring in an electrode assembly may be reduced or prevented. In addition, the alteration of an active agent due to a chemical reaction upon energization may be reduced or prevented.
摘要翻译： 1.一种离子电渗疗法装置，其特征在于，包括具有可极化电极的活性电极组件或对电极组件，所述可极化电极含有每单位重量的电容为1F / g以上的导电材料，比表面积为10m 2 / g以上，并且公开了活性炭。 可以减少或防止由于在电极组件中发生电极反应而产生气体或离子。 此外，可以减少或防止由于通电时的化学反应引起的活性剂的改变。
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公开(公告)号：US08386030B2
公开(公告)日：2013-02-26
申请号：US11501672
申请日：2006-08-08
申请人： Kiyoshi Kanamura , Nobuharu Kosiba , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Kiyoshi Kanamura , Nobuharu Kosiba , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
CPC分类号： A61N1/0436 , A61N1/044 , A61N1/0444 , A61N1/0448
摘要： An iontophoresis device including an active electrode assembly or a counter electrode assembly with a polarizable electrode containing any one of a conductive material having a capacitance per unit weight of 1 F/g or greater, a conductive material having a specific surface area of 10 m2/g or greater, and activated carbon is disclosed. The generation of gas or ions due to an electrode reaction occurring in an electrode assembly may be reduced or prevented. In addition, the alteration of an active agent due to a chemical reaction upon energization may be reduced or prevented.
摘要翻译： 1.一种离子电渗疗法装置，其特征在于，包括具有可极化电极的活性电极组件或对电极组件，所述可极化电极含有每单位重量的电容为1F / g以上的导电材料，比表面积为10m 2 / g以上，并且公开了活性炭。 可以减少或防止由于在电极组件中发生电极反应而产生气体或离子。 此外，可以减少或防止由于通电时的化学反应引起的活性剂的改变。
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公开(公告)号：US07660626B2
公开(公告)日：2010-02-09
申请号：US11195364
申请日：2005-08-02
申请人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
发明人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.
摘要翻译： 本发明提供了具有药物高效给药的离子电渗疗法装置。 一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于 药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。
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公开(公告)号：US20060173401A1
公开(公告)日：2006-08-03
申请号：US11195364
申请日：2005-08-02
申请人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
发明人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.
摘要翻译： 本发明提供了具有药物高效给药的离子电渗疗法装置。 一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于 药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。
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公开(公告)号：US20100100031A1
公开(公告)日：2010-04-22
申请号：US12643720
申请日：2009-12-21
申请人： Akihiko Tanioka , Mie Minegawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
发明人： Akihiko Tanioka , Mie Minegawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.
摘要翻译： 本发明提供了具有药物高效给药的离子电渗疗法装置。 一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于 药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。
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公开(公告)号：US20090216175A1
公开(公告)日：2009-08-27
申请号：US11917733
申请日：2006-08-04
申请人： Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Akihiko Matsumura , Kiyoshi Kanamura , Akihiko Tanioka
发明人： Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Akihiko Matsumura , Kiyoshi Kanamura , Akihiko Tanioka
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0428 , A61N1/0436 , A61N1/0448
摘要： To provide a transdermal administration device capable of increasing the speed at which a drug is transferred into a skin and the amount of the drug to be transferred into the skin. A transdermal administration device is constituted by: an electrode supplied with a voltage of a first conductivity type; an electrolyte solution holding portion holding an electrolyte solution energized by the electrode; and a bipolar membrane that is placed on the front surface side of the electrolyte solution holding portion, and is composed of a first ion exchange membrane that selectively passes an ion of the first conductivity type and a second ion exchange membrane that selectively passes an ion of a second conductivity type.
摘要翻译： 提供能够增加药物转移到皮肤中的速度和要转移到皮肤中的药物的量的透皮给药装置。 透皮给药装置由以下部分构成：供给第一导电型电压的电极; 电解液保持部，其保持由所述电极通电的电解液; 以及放置在电解液保持部的前表面侧的双极性膜，其由选择性地通过第一导电类型的离子的第一离子交换膜和选择性地通过第一导电类型的离子的第二离子交换膜 第二导电类型。
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公开(公告)号：US20070066931A1
公开(公告)日：2007-03-22
申请号：US11501176
申请日：2006-08-07
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/0444
摘要： An iontophoresis device may be capable of preventing or reducing the generation of gas, or the production of undesirable ions, due to an electrode reaction occurring in an electrode assembly; or the alteration of an active agent due to a chemical reaction upon energization. A doping layer made of a substance such as a conductive polymer that effects an electrochemical reaction due to the doping or de-doping of an ion, may be formed in an electrode in an active electrode assembly or counter electrode assembly of an iontophoresis device.
摘要翻译： 离子电渗装置可以由于在电极组件中发生电极反应而能够防止或减少气体的产生或不需要的离子的产生; 或由于通电时的化学反应引起的活性剂的改变。 可以在离子电渗装置的有源电极组件或对电极组件中的电极中形成由诸如导电聚合物的物质制成的掺杂层，其由于离子的掺杂或去掺杂而实现电化学反应。
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公开(公告)号：US08295922B2
公开(公告)日：2012-10-23
申请号：US11501176
申请日：2006-08-07
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/0444
摘要： An iontophoresis device may be capable of preventing or reducing the generation of gas, or the production of undesirable ions, due to an electrode reaction occurring in an electrode assembly; or the alteration of an active agent due to a chemical reaction upon energization. A doping layer made of a substance such as a conductive polymer that effects an electrochemical reaction due to the doping or de-doping of an ion, may be formed in an electrode in an active electrode assembly or counter electrode assembly of an iontophoresis device.
摘要翻译： 离子电渗装置可以由于在电极组件中发生电极反应而能够防止或减少气体的产生或不需要的离子的产生; 或由于通电时的化学反应引起的活性剂的改变。 可以在离子电渗装置的有源电极组件或对电极组件中的电极中形成由诸如导电聚合物的物质制成的掺杂层，其由于离子的掺杂或去掺杂而实现电化学反应。
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公开(公告)号：US20090301882A1
公开(公告)日：2009-12-10
申请号：US11917497
申请日：2006-08-01
IPC分类号： C02F1/469
CPC分类号： A61N1/0448 , A61N1/0436 , A61N1/0444
摘要： An iontophoresis device may include an electrolyte solution holding portion and a drug solution holding portion. The electrolyte solution holding portion holds a solution of an electrolyte that dissociates into a first electrolytic ion of a first polarity type and a second electrolytic ion of a second polarity type in a solution. The drug solution holding portion holds a solution of a drug that dissociates into a drug ion of the first polarity type and a drug counter ion of the second polarity type. The iontophoresis device may also include a first ion exchange membrane with an ion exchange group of the first polarity type and a second ion exchange membrane with an ion exchange group of the second polarity type. The first and the second ion exchange members interpose the electrolyte solution holding portion and the drug solution holding portion.
摘要翻译： 离子电渗装置可以包括电解液保持部和药液保持部。 电解质溶液保持部分保持溶液中解离成第一极性类型的第一电解离子和第二极性类型的第二电解离子的电解质溶液。 药液保持部保持解离成第一极性药物离子的药物溶液和第二极性型药物抗衡离子。 离子电渗装置还可以包括具有第一极性类型的离子交换基团的第一离子交换膜和具有第二极性类型的离子交换基团的第二离子交换膜。 第一和第二离子交换构件插入电解液保持部和药液保持部。
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公开(公告)号：US20070112294A1
公开(公告)日：2007-05-17
申请号：US11522496
申请日：2006-09-14
IPC分类号： A61N1/30
CPC分类号： A61N1/30
摘要： An iontophoresis device may be capable of preventing the generation of gas or ions upon energization, and/or may be capable of preventing the alteration of active agent ions due to an electrode reaction. Energization from an electrode to an active agent reservoir may be performed through an ionic liquid. The ionic liquid may include an anion such as PF6-, BF4-, AlCl4-, ClO4-, a hydrogen sulfate ion, bis-trifluoro-alkyl-sulfonyl-imide, or trifluoro-methane-sulfonate, and a cation such as an imidazolium derivative, a pyridinium derivative, a piperidinium derivative, a pyrolidinium derivative, and a tetra-alkyl-ammonium derivative.
摘要翻译： 离子电渗装置可能能够防止在通电时产生气体或离子，和/或可以防止由于电极反应而引起的活性剂离子的改变。 从电极到活性剂储存器的通电可以通过离子液体进行。 离子液体可以包括阴离子如PF6-，BF4-，AlCl4-，ClO4-，硫酸氢根离子，双 - 三氟 - 烷基 - 磺酰基 - 酰亚胺或三氟 - 甲烷磺酸盐，和阳离子如咪唑鎓 衍生物，吡啶鎓衍生物，哌啶鎓衍生物，吡咯烷鎓衍生物和四烷基铵衍生物。
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