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公开(公告)号：US20130303774A1
公开(公告)日：2013-11-14
申请号：US13990114
申请日：2012-01-27
IPC分类号： C07C29/149 , C07D213/30
CPC分类号： C07C29/149 , B01J31/189 , B01J2231/643 , B01J2531/0258 , B01J2531/821 , C07D213/30 , C07C31/38 , C07C31/42 , C07C33/46 , C07C33/423
摘要： A production method of a β-fluoroalcohol includes performing a reaction of an α-fluoroester with hydrogen gas (H2) in the presence of a specific ruthenium complex (i.e. a ruthenium complex of the general formula [2], preferably a ruthenium complex of the general formula [4]). This production method can employ a suitable hydrogen pressure of 1 MPa or less by the use of such a specific ruthenium complex and does not require a high-pressure gas production facility when put in industrial practice. In addition, this production method can remarkably reduce the amount of catalyst used therein (to e.g. a substrate/catalyst ratio of 20,000) in comparison to the substrate/catalyst ratio conventional reduction of α-fluoroalcohol. It is possible by these reduction in hydrogen pressure and catalyst amount to largely reduce the production cost of the β-fluoroalcohol.
摘要翻译： β-氟代醇的制备方法包括在特定的钌络合物（即通式[2]的钌络合物）存在下进行α-氟代酯与氢气（H 2）的反应，优选的是钌络合物 通式[4]）。 该制造方法可以通过使用这种特定的钌络合物来采用1MPa以下的合适的氢压，并且在投入工业实践中不需要高压气体生产设备。 此外，与通常的α-氟代醇还原反应的底物/催化剂比例相比，该制造方法可以显着地减少其中使用的催化剂的用量（例如基质/催化剂比为20,000）。 通过这些氢气压力和催化剂量的降低可以大大降低β-氟代醇的生产成本。
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公开(公告)号：US08658840B2
公开(公告)日：2014-02-25
申请号：US13990114
申请日：2012-01-27
CPC分类号： C07C29/149 , B01J31/189 , B01J2231/643 , B01J2531/0258 , B01J2531/821 , C07D213/30 , C07C31/38 , C07C31/42 , C07C33/46 , C07C33/423
摘要： A production method of a β-fluoroalcohol includes performing a reaction of an α-fluoroester with hydrogen gas (H2) in the presence of a specific ruthenium complex (i.e. a ruthenium complex of the general formula [2], preferably a ruthenium complex of the general formula [4]). This production method can employ a suitable hydrogen pressure of 1 MPa or less by the use of such a specific ruthenium complex and does not require a high-pressure gas production facility when put in industrial practice. In addition, this production method can remarkably reduce the amount of catalyst used therein (to e.g. a substrate/catalyst ratio of 20,000) in comparison to the substrate/catalyst ratio conventional reduction of α-fluoroalcohol. It is possible by these reduction in hydrogen pressure and catalyst amount to largely reduce the production cost of the β-fluoroalcohol.
摘要翻译： β-氟代醇的制备方法包括在特定的钌络合物（即通式[2]的钌络合物）存在下进行α-氟代酯与氢气（H 2）的反应，优选的是钌络合物 通式[4]）。 该制造方法可以通过使用这种特定的钌络合物来采用1MPa以下的合适的氢压，并且在投入工业实践中不需要高压气体生产设备。 此外，与通常的α-氟代醇还原反应的底物/催化剂比例相比，该制造方法可以显着地减少其中使用的催化剂的用量（例如基质/催化剂比为20,000）。 通过这些氢气压力和催化剂量的降低可以大大降低β-氟代醇的生产成本。
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公开(公告)号：US09040745B2
公开(公告)日：2015-05-26
申请号：US14128362
申请日：2012-06-15
IPC分类号： C07C303/24
CPC分类号： C07C303/24 , C07C305/26
摘要： A production process of a fluorosulfuric acid aromatic-ring ester according to the present invention includes reaction of an aromatic-ring hydroxyl compound with sulfuryl fluoride (SO2F2) in the presence of a tertiary amine except pyridine and methylpyridine. The sulfuryl fluoride, used as the reactant in the production process according to the present invention, is widely adapted as a fumigant and is easily available on a large scale. Further, the target compound can be obtained rapidly with a high yield under moderate reaction conditions in the production process according to the present invention. In this way, all of the prior art problems can be solved in the production process according to the present invention. The production process according to the present invention is thus particularly useful for industrial production of the fluorosulfuric acid aromatic-ring ester.
摘要翻译： 根据本发明的氟代硫酸芳环酯的制备方法包括在除吡啶和甲基吡啶之外的叔胺存在下，芳环羟基化合物与硫酰氟（SO 2 F 2）的反应。 在根据本发明的生产方法中用作反应物的硫酰氟被广泛地用作熏蒸剂，并且容易获得大量。 此外，在本发明的制造方法中，在中等反应条件下，可以快速获得目标化合物。 以这种方式，可以在根据本发明的制造方法中解决所有现有技术问题。 因此，本发明的制造方法特别适用于氟代硫酸芳香环酯的工业化生产。
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公开(公告)号：US20140114088A1
公开(公告)日：2014-04-24
申请号：US14128362
申请日：2012-06-15
IPC分类号： C07C303/24
CPC分类号： C07C303/24 , C07C305/26
摘要： A production process of a fluorosulfuric acid aromatic-ring ester according to the present invention includes reaction of an aromatic-ring hydroxyl compound with sulfuryl fluoride (SO2F2) in the presence of a tertiary amine except pyridine and methylpyridine. The sulfuryl fluoride, used as the reactant in the production process according to the present invention, is widely adapted as a fumigant and is easily available on a large scale. Further, the target compound can be obtained rapidly with a high yield under moderate reaction conditions in the production process according to the present invention. In this way, all of the prior art problems can be solved in the production process according to the present invention. The production process according to the present invention is thus particularly useful for industrial production of the fluorosulfuric acid aromatic-ring ester.
摘要翻译： 根据本发明的氟代硫酸芳环酯的制备方法包括在除吡啶和甲基吡啶之外的叔胺存在下，芳环羟基化合物与硫酰氟（SO 2 F 2）的反应。 在根据本发明的生产方法中用作反应物的硫酰氟被广泛地用作熏蒸剂，并且容易获得大量。 此外，在本发明的制造方法中，在中等反应条件下，可以快速获得目标化合物。 以这种方式，可以在根据本发明的制造方法中解决所有现有技术问题。 因此，本发明的制造方法特别适用于氟代硫酸芳香环酯的工业化生产。
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5.发明申请Process for Producing Fluoroalkylsulfonylaminoethyl Alpha-Substituted-Acrylate 审中-公开制备氟烷基磺酰氨基乙基α-取代的丙烯酸酯的方法公开(公告)号：US20110237824A1
公开(公告)日：2011-09-29
申请号：US13131487
申请日：2009-12-22
申请人： Takehisa Ishimaru , Ryo Nadano , Makoto Matsuura
发明人： Takehisa Ishimaru , Ryo Nadano , Makoto Matsuura
IPC分类号： C07C307/02
CPC分类号： C07C303/38 , C07C303/40 , C07C311/09
摘要： Aminoethanol is reacted with a fluoroalkylsulfonic anhydride to obtain a fluoroalkylsulfonylaminoethanol (first step: sulfonylamidation step). The fluoroalkylsulfonylaminoethanol is esterified with an α-substituted acrylate derivative to obtain a desired fluoroalkylsulfonylaminoethyl α-substituted-acrylate (second step: esterification step). Thus, the desired fluoroalkylsulfonylaminoethyl α-substituted-acrylate having a higher purity can be produced in higher yield with higher operating efficiency than in conventional techniques.
摘要翻译： 氨基乙醇与氟烷基磺酸酐反应得到氟代烷基磺酰基氨基乙醇（第一步：磺酰胺化步骤）。 氟代烷基磺酰基氨基乙醇用α-取代的丙烯酸酯衍生物酯化，得到所需的氟代烷基磺酰基氨基乙基α-取代的丙烯酸酯（第二步：酯化步骤）。 因此，与常规技术相比，具有更高纯度的所需氟代烷基磺酰基氨基乙基α-取代的丙烯酸酯可以以更高的产率生产，具有更高的操作效率。
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