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公开(公告)号：US20130122103A1
公开(公告)日：2013-05-16
申请号：US13812383
申请日：2011-07-27
申请人： Akihiro Kishimura , Kazunori Kataoka , Stephanie Lee , Yasutaka Anraku , Aya Koide , Mitsuru Sakai , QiuMing Yu
发明人： Akihiro Kishimura , Kazunori Kataoka , Stephanie Lee , Yasutaka Anraku , Aya Koide , Mitsuru Sakai , QiuMing Yu
CPC分类号： C08G81/00 , A61K9/1273 , A61K9/1641 , C08G69/10 , C08G73/0233 , C08L77/04 , C08L2205/02 , Y10T428/2989
摘要： The purpose of the present invention is to provide an electrostatically bonded vesicle which bears disulfide bonds or thiol groups. The present invention relates to a vesicle having a membrane which is formed from both a first polymer of (a) or (b) and a second polymer of (c) or (d) (with the proviso that a combination of (b) and (d) is excepted) and in which the cationic segment and anionic segment of the polymers are partially crosslinked. First polymer: (a) a block copolymer (I) having both an electrically non-charged hydrophilic segment and a cationic segment, (b) an amino acid polymer (I) having a cationic segment. Second polymer: (c) a block copolymer (II) having both an electrically non-charged hydrophilic segment and an anionic segment, (d) an amino acid polymer (II) having an anionic segment.
摘要翻译： 本发明的目的是提供一种带有二硫键或硫醇基的静电粘结囊泡。 本发明涉及具有由（a）或（b）的第一聚合物和（c）或（d）的第二聚合物形成的膜的囊泡（条件是（b）和 （d）除外），其中聚合物的阳离子链段和阴离子链段部分交联。 第一聚合物：（a）具有不带电荷的亲水链段和阳离子链段的嵌段共聚物（I），（b）具有阳离子链段的氨基酸聚合物（I）。 第二聚合物：（c）具有不带电荷的亲水链段和阴离子链段的嵌段共聚物（II），（d）具有阴离子链段的氨基酸聚合物（II）。
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公开(公告)号：US09051437B2
公开(公告)日：2015-06-09
申请号：US13812383
申请日：2011-07-27
申请人： Akihiro Kishimura , Kazunori Kataoka , Stephanie Lee , Yasutaka Anraku , Aya Koide , Mitsuru Sakai , QiuMing Yu
发明人： Akihiro Kishimura , Kazunori Kataoka , Stephanie Lee , Yasutaka Anraku , Aya Koide , Mitsuru Sakai , QiuMing Yu
CPC分类号： C08G81/00 , A61K9/1273 , A61K9/1641 , C08G69/10 , C08G73/0233 , C08L77/04 , C08L2205/02 , Y10T428/2989
摘要： The purpose of the present invention is to provide an electrostatically bonded vesicle which bears disulfide bonds or thiol groups. The present invention relates to a vesicle having a membrane which is formed from both a first polymer of (a) or (b) and a second polymer of (c) or (d) (with the proviso that a combination of (b) and (d) is excepted) and in which the cationic segment and anionic segment of the polymers are partially crosslinked. First polymer: (a) a block copolymer (I) having both an electrically non-charged hydrophilic segment and a cationic segment, (b) an amino acid polymer (I) having a cationic segment. Second polymer: (c) a block copolymer (II) having both an electrically non-charged hydrophilic segment and an anionic segment, (d) an amino acid polymer (II) having an anionic segment.
摘要翻译： 本发明的目的是提供一种带有二硫键或硫醇基的静电粘结囊泡。 本发明涉及具有由（a）或（b）的第一聚合物和（c）或（d）的第二聚合物形成的膜的囊泡（条件是（b）和 （d）除外），其中聚合物的阳离子链段和阴离子链段部分交联。 第一聚合物：（a）具有不带电荷的亲水链段和阳离子链段的嵌段共聚物（I），（b）具有阳离子链段的氨基酸聚合物（I）。 第二聚合物：（c）具有不带电荷的亲水链段和阴离子链段的嵌段共聚物（II），（d）具有阴离子链段的氨基酸聚合物（II）。
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公开(公告)号：US09750687B2
公开(公告)日：2017-09-05
申请号：US13699238
申请日：2011-05-23
申请人： Kazunori Kataoka , Akihiro Kishimura , Yasutaka Anraku , Kanjiro Miyata , Sayan Chuanoi , Tomoya Suma , Makoto Oba
发明人： Kazunori Kataoka , Akihiro Kishimura , Yasutaka Anraku , Kanjiro Miyata , Sayan Chuanoi , Tomoya Suma , Makoto Oba
CPC分类号： A61K9/0087 , A61K9/1273 , B01J13/02 , B01J13/14
摘要： Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly. Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces.
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公开(公告)号：US20130202711A1
公开(公告)日：2013-08-08
申请号：US13699238
申请日：2011-05-23
申请人： Kazunori Kataoka , Akihiro Kishimura , Yasutaka Anraku , Kanjiro Miyata , Sayan Chuanoi , Tomoya Suma , Makoto Oba
发明人： Kazunori Kataoka , Akihiro Kishimura , Yasutaka Anraku , Kanjiro Miyata , Sayan Chuanoi , Tomoya Suma , Makoto Oba
IPC分类号： A61K9/00
CPC分类号： A61K9/0087 , A61K9/1273 , B01J13/02 , B01J13/14
摘要： Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly. Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces.
摘要翻译： 本发明提供一种容易且高效地生产包封物质囊泡的方法，其中物质被包封在通过聚合物自组装获得的囊泡的空腔中。 具有包含第一聚合物的空泡，所述第一聚合物是具有不带电的亲水链段的嵌段共聚物和第一种带电链段，第二聚合物具有携带与所述第一类电荷相反的电荷的第二类电荷链段 由所述膜包围的片段以及空间在水性介质中与待封装在空间中的物质混合。
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