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公开(公告)号：US20090011424A1
公开(公告)日：2009-01-08
申请号：US12219508
申请日：2008-07-23
申请人： Akiko Misawa , Jun Inoue , Issei Imoto , Johji Inazawa
发明人： Akiko Misawa , Jun Inoue , Issei Imoto , Johji Inazawa
IPC分类号： C12Q1/68
CPC分类号： C07K14/70567 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , G01N33/57407
摘要： It is an object of the present invention to provide a cancer-suppressing agent comprising a novel cancer-suppressing gene based on the discovery of such cancer-suppressing gene. The present invention provides a cancer-suppressing agent which comprises NR1I2 gene or a homologous gene thereof; and a cancer-suppressing agent which comprises NR1I2 protein or a homologous protein thereof.
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公开(公告)号：US20070237813A1
公开(公告)日：2007-10-11
申请号：US11585142
申请日：2006-10-24
申请人： Akiko Misawa , Jun Inoue , Issei Imoto , Johji Inazawa
发明人： Akiko Misawa , Jun Inoue , Issei Imoto , Johji Inazawa
IPC分类号： A61K9/127 , C07H21/04 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/70567 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , G01N33/57407
摘要： It is an object of the present invention to provide a cancer-suppressing agent comprising a novel cancer-suppressing gene based on the discovery of such cancer-suppressing gene. The present invention provides a cancer-suppressing agent which comprises NR1I2 gene or a homologous gene thereof, and a cancer-suppressing agent which comprises NR1I2 protein or a homologous protein thereof.
摘要翻译： 本发明的目的是提供一种基于这种癌症抑制基因的发现而含有新型癌抑制基因的癌抑制剂。 本发明提供了包含NR1I2基因或其同源基因的癌抑制剂和包含NR1I2蛋白质或其同源蛋白质的癌抑制剂。
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公开(公告)号：US20090074849A1
公开(公告)日：2009-03-19
申请号：US12153342
申请日：2008-05-16
申请人： Akiko Misawa , Jun Inoue , Issei Imoto , Johji Inazawa
发明人： Akiko Misawa , Jun Inoue , Issei Imoto , Johji Inazawa
CPC分类号： C07K14/70567 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/154 , G01N33/57407
摘要： It is an object of the present invention to provide a cancer-suppressing agent comprising a novel cancer-suppressing gene based on the discovery of such cancer-suppressing gene. The present invention provides a cancer-suppressing agent which comprises NR1I2 gene or a homologous gene thereof; and a cancer-suppressing agent which comprises NR1I2 protein or a homologous protein thereof.
摘要翻译： 本发明的目的是提供一种基于这种癌症抑制基因的发现而含有新型癌抑制基因的癌抑制剂。 本发明提供了包含NR1I2基因或其同源基因的癌抑制剂; 以及包含NR1I2蛋白或其同源蛋白质的癌抑制剂。
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公开(公告)号：US20070161018A1
公开(公告)日：2007-07-12
申请号：US11591482
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in bile duct cancer as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在胆管癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US20100105868A1
公开(公告)日：2010-04-29
申请号：US12568569
申请日：2009-09-28
申请人： Johji Inazawa , Issei Imoto , Jun Inoue
发明人： Johji Inazawa , Issei Imoto , Jun Inoue
IPC分类号： C07K14/435 , C12Q1/68 , C12N5/02 , C07H21/04
CPC分类号： G01N33/57407 , A61K38/00 , C12Q1/6886 , C12Q2600/154
摘要： The present invention is intended to provide a means for judging the malignancy of neuroblastoma and the progress of spontaneous regression thereof. The present invention provides a method for detecting cancer which comprises detecting activation or inactivation of the lysosomal-associated protein multispanning transmembrane 5 (LAPTM5) gene and amplification of the MYCN gene in a specimens to evaluate the malignancy of the specimens and the progress of spontaneous regression.
摘要翻译： 本发明旨在提供一种判断神经母细胞瘤的恶性程度及其自发消退的方法。 本发明提供一种检测癌症的方法，其包括检测样品中溶酶体相关蛋白多能跨膜5（LAPTM5）基因的活化或失活以及MYCN基因的扩增，以评估标本的恶性程度和自发回归的进展 。
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公开(公告)号：US20080108061A1
公开(公告)日：2008-05-08
申请号：US11591487
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki , Itaru Sonoda
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki , Itaru Sonoda
CPC分类号： C12N15/113 , A61K38/00 , A61K48/005 , C12N15/86 , C12N2310/11 , C12N2760/18843 , C12Q1/6886 , C12Q2600/112
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in brain tumor as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells among these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测细胞癌变和癌症恶性程度的指标的癌症相关基因，以提供使用癌症相关基因作为指标检测癌症的方法，以及 提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现了与正常细胞相比在脑肿瘤中扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些癌症相关基因中的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US20070161019A1
公开(公告)日：2007-07-12
申请号：US11591637
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki , Itaru Sonoda
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki , Itaru Sonoda
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in lung cancer as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells amond these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在肺癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些与癌症相关的基因的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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公开(公告)号：US20080312093A1
公开(公告)日：2008-12-18
申请号：US11591489
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in gastric carcinoma as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells among these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测细胞癌变和癌症恶性程度的指标的癌症相关基因，以提供使用癌症相关基因作为指标检测癌症的方法，以及 提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在胃癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些癌症相关基因中的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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9.发明申请公开(公告)号：US20080182250A1
公开(公告)日：2008-07-31
申请号：US11902504
申请日：2007-09-21
申请人： Chen Zhao , Jun Inoue , Issei Imoto , Johji Inazawa
发明人： Chen Zhao , Jun Inoue , Issei Imoto , Johji Inazawa
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： It is an object of the present invention to identify a gene that relates to exhibition of behavior peculiar to cancer such as multiple myeloma to provide a method for detecting cancer and a cell-growth inhibitor. The present invention provides a method for detecting cancer which comprises detecting and/or typing tumorigenesis of a specimen by employing gene amplification in the chromosome 11 q23 region of the specimen as an indicator.
摘要翻译： 本发明的目的是鉴定与多发性骨髓瘤等癌症特有的显示有关的基因，提供检测癌症的方法和细胞生长抑制剂。 本发明提供了一种检测癌症的方法，其包括通过在样本的染色体11q23区域中进行基因扩增作为指标检测和/或分类标本的肿瘤发生。
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公开(公告)号：US20080032943A1
公开(公告)日：2008-02-07
申请号：US11591469
申请日：2006-11-02
申请人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
发明人： Johji Inazawa , Issei Imoto , Jun Inoue , Akiko Furihata , Sana Yokoi , Itaru Sonoda , Hideaki Tanami , Hiroyuki Izumi , Kuniyasu Saigusa , Shin Hayashi , Hisashi Takada , Ayako Suzuki
CPC分类号： C12Q1/6886 , C12Q2600/156 , C12Q2600/158
摘要： An object of the invention is to find a cancer-associated gene to be used as an index for detecting canceration of cells and degree of malignancy of cancer, so as to to provide a method for detecting cancer using the cancer-associated gene as an index and provide a method of suppressing/treating cancer using the cancer-associated gene as essential part. According to the present invention, specific genes which are amplified or deleted in thyroid carcinoma as compared with normal cell have been collectively found, and a method for detecting cancer using amplification or deletion of these cancer-associated genes as an index is provided. Further, cancer can be suppressed by introducing a gene which is deleted in cancer cells among these cancer-associated genes into cancer and inhibiting the transcription product of the gene amplified.
摘要翻译： 本发明的目的是找到用作检测癌细胞癌变的指标和癌症恶性程度的指标的癌症相关基因，以便提供使用癌症相关基因作为指标检测癌症的方法 并提供使用癌症相关基因作为必需部分抑制/治疗癌症的方法。 根据本发明，已经共同发现在甲状腺癌中与正常细胞相比扩增或缺失的特定基因，并且提供了使用这些癌症相关基因的扩增或缺失作为指标来检测癌症的方法。 此外，通过将这些癌症相关基因中的癌细胞中缺失的基因导入癌症并抑制扩增的基因的转录产物，可以抑制癌症。
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